Q3UFB2
Gene name |
Znhit6 (Bcd1) |
Protein name |
Box C/D snoRNA protein 1 |
Names |
Zinc finger HIT domain-containing protein 6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:229937 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3UFB2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3UFB2-F1 | Predicted | AlphaFoldDB |
23 variants for Q3UFB2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs216623302 | 68 | A>V | No | EVA | |
| rs234333838 | 82 | S>G | No | EVA | |
| rs256426047 | 116 | S>T | No | EVA | |
| rs222352495 | 165 | E>K | No | EVA | |
| rs3388662994 | 173 | P>S | No | EVA | |
| rs244436782 | 188 | A>V | No | EVA | |
| rs265589571 | 190 | V>L | No | EVA | |
| rs232718314 | 196 | M>V | No | EVA | |
| rs242325523 | 208 | L>M | No | EVA | |
| rs36463295 | 229 | F>Y | No | EVA | |
| rs235753404 | 246 | S>N | No | EVA | |
| rs3388668882 | 272 | L>W | No | EVA | |
| rs3388656852 | 276 | A>T | No | EVA | |
| rs3388672807 | 327 | V>F | No | EVA | |
| rs3388669410 | 361 | I>V | No | EVA | |
| rs3388649373 | 390 | T>S | No | EVA | |
| rs3388672283 | 397 | R>G | No | EVA | |
| rs3388669454 | 401 | M>I | No | EVA | |
| rs3388663000 | 418 | S>* | No | EVA | |
| rs3388665349 | 419 | D>N | No | EVA | |
| rs3388669464 | 426 | I>M | No | EVA | |
| rs3393782489 | 433 | H>Y | No | EVA | |
| rs36623898 | 443 | K>M | No | EVA |
No associated diseases with Q3UFB2
1 regional properties for Q3UFB2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, HIT-type | 210 - 245 | IPR007529 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| pre-snoRNP complex | A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| identical protein binding | Binding to an identical protein or proteins. |
| metal ion binding | Binding to a metal ion. |
| TFIID-class transcription factor complex binding | Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| box C/D snoRNP assembly | The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex. |
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| protein complex oligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| snoRNA localization | Any process in which small nucleolar RNA is transported to, or maintained in, a specific location. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38772 | BCD1 | Box C/D snoRNA protein 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESAAEKEGT | PGGGSQRVAE | GARPRPAAGG | EGARDLDGSP | EAGDGEERNG | LAGTKTTEDA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EEIKMDLAVV | KQEVVDWSDL | DSGVADSQWV | KQEVEGGPEV | KDEKGVLEVK | QEADSSLVVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEEVDEPEVK | EEKVKVKEEV | TDWEEVKEED | LTIKQELFVG | QNVKEEQVMD | AAPIKEEGSL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KSEAMEDAKV | KEEPQMNPRV | GSKRKLALSR | CETCGTEEAK | YRCPRCMRFS | CSLPCVKKHK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ADLTCSGVRD | KTAYVSLQQF | TEMNLLSDYR | FLEDVARTAD | KVSRDTFLKR | PKRKKYLFFM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KNRARKQGIY | LRLLPNGFSK | RKENSTVFDH | RKQQFCWHVK | LQFPQSQAEY | IEKRVPDDKT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| INEILKPYID | PEESDPVIRQ | RLKAYAQSQT | GVQILMRVEN | MQQNMIRYHE | LDPYKSLSDN |
| 430 | 440 | 450 | |||
| LKDKVIIEYP | TLHVVLRGSS | NDKQLLQVKS | ESAQKLGNGN |