P38772
Gene name |
BCD1 (YHR040W) |
Protein name |
Box C/D snoRNA protein 1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHR040W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P38772
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2N94 | NMR | - | A | 1-45 | PDB |
| 6NZ2 | NMR | - | A | 120-303 | PDB |
| 6THL | X-ray | 280 A | B | 120-303 | PDB |
| AF-P38772-F1 | Predicted | AlphaFoldDB |
7 variants for P38772
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-187921 | 2 | A>V | No | SGRP | |
| s08-188181 | 89 | D>N | No | SGRP | |
| s08-188781 | 289 | T>A | No | SGRP | |
| s08-188835 | 307 | L>V | No | SGRP | |
| s08-188839 | 308 | E>G | No | SGRP | |
| s08-188866 | 317 | I>T | No | SGRP | |
| s08-188951 | 345 | S>R | No | SGRP |
No associated diseases with P38772
1 regional properties for P38772
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, HIT-type | 2 - 39 | IPR007529 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| pre-snoRNP complex | A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| snoRNA binding | Binding to a small nucleolar RNA. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| box C/D snoRNP assembly | The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex. |
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| ribosome biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. |
| sno(s)RNA metabolic process | The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. |
| snoRNA localization | Any process in which small nucleolar RNA is transported to, or maintained in, a specific location. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3UFB2 | Znhit6 | Box C/D snoRNA protein 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVLCGVCGI | KEFKYKCPRC | LVQTCSLECS | KKHKTRDNCS | GQTHDPKEYI | SSEALKQADD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DKHERNAYVQ | RDYNYLTQLK | RMVHVQKMDA | RMKNKRVLGP | VGGHNSNFKK | RRYDIDEDDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DSTECQRIIR | RGVNCLMLPK | GMQRSSQNRS | KWDKTMDLFV | WSVEWILCPM | QEKGEKKELF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KHVSHRIKET | DFLVQGMGKN | VFQKCCEFYR | LAGTSSCIEG | EDGSETKEER | TQILQKSGLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FYTKTFPYNT | THIMDSKKLV | ELAIHEKCIG | ELLKNTTVIE | FPTIFVAMTE | ADLPEGYEVL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HQEPRPLEHT | STLNKFIDNA | REEEDAEEDS | QPTEEPVQKE | TQDASDSDSD | SDDDYNPGLS |
| MDFLTA |