AiPD: Autoinhibited Protein Database

Gene name	Ttll12
Protein name	Tubulin--tyrosine ligase-like protein 12
Names	Inactive tubulin--tyrosine ligase-like protein 12
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:223723
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-119 (Predicted disordered autoinhibitory region) PR

1-119 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3UDE2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389385625	49	H>D	No	EVA
rs3389342096	52	E>K	No	EVA
rs3389381913	79	R>W	No	EVA
rs31717119	83	R>K	No	EVA
rs3389347035	87	N>T	No	EVA
rs3389347053	100	S>N	No	EVA
rs3389376261	101	E>K	No	EVA
rs3413119009	104	V>I	No	EVA
rs3389369103	106	A>T	No	EVA
rs3389380779	121	C>*	No	EVA
rs3389393764	142	N>Y	No	EVA
rs3389371863	165	M>I	No	EVA
rs3389297603	185	V>A	No	EVA
rs3406067579	222	W>G	No	EVA
rs3389379636	258	D>N	No	EVA
rs3389372996	289	I>V	No	EVA
rs3389385630	299	V>I	No	EVA
rs3405820836	321	T>S	No	EVA
rs3405478128	325	A>G	No	EVA
rs3389380862	339	Y>*	No	EVA
rs3389340537	340	M>K	No	EVA
rs3389297623	348	Q>*	No	EVA
rs3389372960	352	N>S	No	EVA
rs3389393805	422	L>M	No	EVA
rs3389379655	438	E>K	No	EVA
rs3389371831	439	S>N	No	EVA
rs3389358296	446	K>N	No	EVA
rs3389347033	461	N>K	No	EVA
rs3389369104	474	S>P	No	EVA
rs3389340582	508	T>I	No	EVA
rs3406464522	512	Y>S	No	EVA
rs3389380786	552	E>V	No	EVA
rs3389393737	579	D>N	No	EVA
rs3389372961	579	D>V	No	EVA
rs3389380801	599	L>V	No	EVA
rs3389375259	619	N>S	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q3UDE2

		Description
EC Number
Subcellular Localization	Cytoplasm Midbody Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Nucleus	Predominantly localizes in the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule organizing center	An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

Name	Definition
acid-amino acid ligase activity	Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
H4K20me3 modified histone binding	Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation.
tubulin binding	Binding to monomeric or multimeric forms of tubulin, including microtubules.

Name	Definition
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of type I interferon-mediated signaling pathway	Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway.
protein modification process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
regulation of mitotic cell cycle	Any process that modulates the rate or extent of progress through the mitotic cell cycle.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q14166	TTLL12	Tubulin--tyrosine ligase-like protein 12	Homo sapiens (Human)	PR
Q09512	ttll-12	Tubulin--tyrosine ligase-like protein 12	Caenorhabditis elegans	PR