Q09512

PR
Gene name
ttll-12
Protein name
Tubulin--tyrosine ligase-like protein 12
Names
Inactive tubulin--tyrosine ligase-like protein 12
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_D2013.9
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

270-341 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09512

Entry ID Method Resolution Chain Position Source
AF-Q09512-F1 Predicted AlphaFoldDB

No variants for Q09512

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q09512

No associated diseases with Q09512

No regional properties for Q09512

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q09512

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
sarcomere The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
striated muscle dense body A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.

1 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

2 GO annotations of biological process

Name Definition
oviposition The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.
protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 Homo sapiens (Human) PR
Q3UDE2 Ttll12 Tubulin--tyrosine ligase-like protein 12 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSEDRSAYPF STFLDQHSGQ LNASDVPPEL WHSLYKKLSD QTFDAGDHFQ IICEMNEDDE
70 80 90 100 110 120
KTLFVRALED LHNNDEDNIF LIDHFMSFSS ESARKCVEST EGLVERLAGL FGIDTDSTEE
130 140 150 160 170 180
VDETVEKIET SVEKEEAEHA KKISSETGNL PRHESVDARL SSYSVDDPKN ELTEKVLKAL
190 200 210 220 230 240
WKYSQTYSVS YQLDNGEIEK KSVWYVMDDF GTRVRHSTEP NVRIVPLMFL PQNCAYSIMF
250 260 270 280 290 300
LTKPVNTDEE IMMDWASNVI TAQHPEWRKY IEQPWAAQDF SKETMIPDAP TLEYFTSGRN
310 320 330 340 350 360
PDFLAGPTEQ QTCQSAIFTS LPILKKRKIK VYADDTQLTE HLKNHKVEYV DDIKKADVIW
370 380 390 400 410 420
MIKHFHDYKQ LSEENPCGMI NQFPFESCIT VKDLLAACAM RDPAKNDWYQ LTYNLNTQLP
430 440 450 460 470 480
EFVARFQNRE LNGQHNVWIV KPWNLARGMD MTVTEDLNQI IRMIETGPKI VCEYIPRPLL
490 500 510 520 530 540
FPRPDNGNKV KFDLRYIVFL NGIAPVTAYV YNRFWIRFAI NEFSLSNFED VETHFTVFNY
550 560 570 580 590 600
LDKEKILQMK CENFIETIEK AYPRIQWSEV QKDINLTIRK AIEAAAKEEA PRGVAPNVQS
610 620 630 640 650 660
RAMYGVDIML QHGDNDVIKS TLLEINFMPD TTRACQYYPD FADTVFETLF LDEIDPTKVT
PI