Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q3UBG2

Entry ID Method Resolution Chain Position Source
AF-Q3UBG2-F1 Predicted AlphaFoldDB

16 variants for Q3UBG2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388483556 12 F>Y No EVA
rs3388483053 15 M>I No EVA
rs3388484576 35 F>I No EVA
rs3388482252 52 A>V No EVA
rs3388484729 54 T>N No EVA
rs242338032 66 V>I No EVA
rs3388483725 93 R>Q No EVA
rs3388483551 110 V>M No EVA
rs3388483023 130 V>L No EVA
rs3388484633 152 R>K No EVA
rs3388483881 156 D>G No EVA
rs3388483012 174 E>* No EVA
rs3388482602 180 H>Y No EVA
rs3388483547 196 D>G No EVA
rs3388483812 199 I>N No EVA
rs3412974113 214 S>F No EVA

No associated diseases with Q3UBG2

2 regional properties for Q3UBG2

Type Name Position InterPro Accession
domain PTB/PI domain 53 - 203 IPR006020
domain PID1, PTB domain 56 - 194 IPR039114

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

18 GO annotations of biological process

Name Definition
cellular response to cytokine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
cellular response to fatty acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
cellular response to interleukin-6 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
cellular response to leptin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
mitochondrion morphogenesis The process in which the anatomical structures of a mitochondrion are generated and organized.
negative regulation of ATP biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process.
negative regulation of glucose import Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
negative regulation of insulin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
negative regulation of protein localization to plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.
negative regulation of protein phosphorylation Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
positive regulation of ATP biosynthetic process Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
positive regulation of fat cell proliferation Any process that activates or increases the rate or extent of fat cell proliferation.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of reactive oxygen species metabolic process Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of mitochondrial membrane potential Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
regulation of reactive oxygen species metabolic process Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7Z2X4 PID1 PTB-containing, cubilin and LRP1-interacting protein Homo sapiens (Human) PR
10 20 30 40 50 60
MWQPATERLQ HFQTMLKSKL NVLTLKKEPI PAVLFHEPEA IELCTTTPLM KARTHSGCKV
70 80 90 100 110 120
TYLGKVSTTG MQFLSGCTEK PVIELWKKHT LAREDVFPAN ALLEIRPFQV WLHHLDHKGE
130 140 150 160 170 180
ATVHMDTFQV ARIAYCTADH NVSPNIFAWV YREINDDLSY QMDCHAVQCE SKLEAKKLAH
190 200 210
AMMEAFKKTF HSMKSDGRIH RSSSSEEASQ ELESDDG