AiPD: Autoinhibited Protein Database

Gene name	Cmpk2 (Tyki)
Protein name	UMP-CMP kinase 2, mitochondrial
Names	Nucleoside-diphosphate kinase, Thymidylate kinase LPS-inducible member, TYKi
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:22169
EC number	2.7.4.6: Phosphotransferases with a phosphate group as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

356-426 (Predicted disordered autoinhibitory region) PR

356-426 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3U5Q7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs212012615	21	C>W	No	EVA
rs236885264	22	G>A	No	EVA
rs3389244474	39	V>E	No	EVA
rs3389248349	50	V>I	No	EVA
rs263567744	57	H>Y	No	EVA
rs222014555	96	H>Q	No	EVA
rs3402657687	104	R>P	No	EVA
rs3403124096	104	R>W	No	EVA
rs13468593	105	G>D	No	EVA
rs3389241720	123	Q>*	No	EVA
rs3389232255	134	R>W	No	EVA
rs3389233635	164	F>I	No	EVA
rs3389208976	171	L>S	No	EVA
rs3389195514	178	E>G	No	EVA
rs240307284	196	Q>L	No	EVA
rs3402403736	211	A>P	No	EVA
rs3389233644	213	F>S	No	EVA
rs3389166730	219	A>T	No	EVA
rs3389232595	221	A>D	No	EVA
rs3389220597	221	A>T	No	EVA
rs3389237637	327	V>D	No	EVA
rs3389195474	335	S>T	No	EVA
rs3402403757	355	A>G	No	EVA
rs3403168341	363	P>A	No	EVA
rs240244394	364	G>R	No	EVA
rs3389202991	402	A>T	No	EVA
rs3389203057	414	Y>N	No	EVA
rs3389232599	437	K>T	No	EVA

Type	Name	Position	InterPro Accession
domain	Thymidylate kinase-like domain	257 - 437	IPR039430

		Description
EC Number	2.7.4.6	Phosphotransferases with a phosphate group as acceptor
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CMP kinase activity	Catalysis of the reaction: ATP + CMP = ADP + CDP.
cytidylate kinase activity	Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.
dCMP kinase activity	Catalysis of the reaction: ATP + dCMP = ADP + dCDP.
nucleoside diphosphate kinase activity	Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
thymidylate kinase activity	Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.
UMP kinase activity	Catalysis of the reaction: ATP + UMP = ADP + UDP.
uridylate kinase activity	Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.

Name	Definition
cellular response to lipopolysaccharide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
dTDP biosynthetic process	The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).
dTTP biosynthetic process	The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.
dUDP biosynthetic process	The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate).
nucleoside diphosphate phosphorylation	The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate.
nucleoside triphosphate biosynthetic process	The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P97930	Dtymk	Thymidylate kinase	Mus musculus (Mouse)	PR