P97930

PR
Gene name
Dtymk (Tmk)
Protein name
Thymidylate kinase
Names
dTMP kinase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:21915
EC number
2.7.4.9: Phosphotransferases with a phosphate group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

160-212 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P97930

Entry ID Method Resolution Chain Position Source
AF-P97930-F1 Predicted AlphaFoldDB

11 variants for P97930

Variant ID(s) Position Change Description Diseaes Association Provenance
rs582035419 17 A>V No EVA
rs3388491746 45 R>S No EVA
rs3388491617 57 L>S No EVA
rs3388489890 64 E>D No EVA
rs3388490366 107 G>D No EVA
rs3388489029 118 K>E No EVA
rs3388489942 126 K>T No EVA
rs3388490463 135 L>V No EVA
rs3388490526 147 G>D No EVA
rs3388490397 172 N>I No EVA
rs3388489950 209 E>K No EVA

No associated diseases with P97930

2 regional properties for P97930

Type Name Position InterPro Accession
conserved_site Thymidylate kinase, conserved site 94 - 106 IPR018095
domain Thymidylate kinase-like domain 11 - 191 IPR039430

Functions

Description
EC Number 2.7.4.9 Phosphotransferases with a phosphate group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
nucleoside diphosphate kinase activity Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
thymidylate kinase activity Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.
uridylate kinase activity Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.

7 GO annotations of biological process

Name Definition
cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
dTDP biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).
dTTP biosynthetic process The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.
dUDP biosynthetic process The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate).
nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
thymidine biosynthetic process The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3U5Q7 Cmpk2 UMP-CMP kinase 2, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MASRRGALIV LEGVDRAGKT TQGLKLVTAL CASGHRAELL RFPERSTEIG KLLNSYLEKK
70 80 90 100 110 120
TELEDHSVHL LFSANRWEQV PLIKAKLNQG VTLVLDRYAF SGVAFTGAKE NFSLDWCKQP
130 140 150 160 170 180
DVGLPKPDLI LFLQLQLLDA AARGEFGLER YETGTFQKQV LLCFQQLMEE KNLNWKVVDA
190 200 210
SKSIEEVHKE IRAHSEDAIR NAAQRPLGEL WK