Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q3U3R4

Entry ID Method Resolution Chain Position Source
AF-Q3U3R4-F1 Predicted AlphaFoldDB

29 variants for Q3U3R4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389445567 26 S>N No EVA
rs260462643 32 S>P No EVA
rs3389453963 48 T>I No EVA
rs3389355660 51 L>Q No EVA
rs47831671 93 N>T No EVA
rs46488937 105 A>T No EVA
rs260972199 108 T>I No EVA
rs3389413453 110 A>V No EVA
rs265190596 113 I>V No EVA
rs3389355684 114 M>V No EVA
rs3389459414 123 N>D No EVA
rs244143086 136 I>L No EVA
rs3389435426 297 L>P No EVA
rs3389404413 298 F>I No EVA
rs3389422499 390 S>N No EVA
rs3389445549 429 P>L No EVA
rs3389444947 432 S>I No EVA
rs3389451149 433 A>T No EVA
rs13474912 442 E>* No EVA
rs3407863698 465 D>E No EVA
rs3406917146 465 D>V No EVA
rs3389392709 471 A>T No EVA
rs3389451073 472 A>D No EVA
rs233590091 482 I>L No EVA
rs3389453923 508 R>K No EVA
rs3389442563 518 H>Y No EVA
rs3389453881 528 G>D No EVA
rs3389392718 536 W>L No EVA
rs3389435498 540 K>N No EVA

1 associated diseases with Q3U3R4

Without disease ID

No regional properties for Q3U3R4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3U3R4

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

9 GO annotations of biological process

Name Definition
chylomicron remnant clearance The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded.
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
positive regulation of lipoprotein lipase activity Any process that activates or increases the activity of the enzyme lipoprotein lipase.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
protein maturation Any process leading to the attainment of the full functional capacity of a protein.
protein secretion The controlled release of proteins from a cell.
regulation of cholesterol metabolic process Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
regulation of triglyceride metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.
triglyceride metabolic process The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0P5C0 LMF1 Lipase maturation factor 1 Bos taurus (Bovine) PR
Q96S06 LMF1 Lipase maturation factor 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MRPDSLVMAA PEGSLRKRKV GGAEHSPASQ PSLARDPADS PARLHTGTFW LTRIVLLRAL
70 80 90 100 110 120
AFIYFVAFLV AFNQNKALIG DRGLLPCKLY LKNVQEYFQG STGWAAWTYA PTIMWLLDWS
130 140 150 160 170 180
DMNFNLDLIA LLGLGISSFV LVTGCANMIL MTALWALYMS LVNVGQIWYS FGWESQLLET
190 200 210 220 230 240
GFLGIFLSPL WTLSRLPKNT PTSQIVLWGF RWLIFRIMLG AGLIKVRGDK CWLDLTCMDF
250 260 270 280 290 300
HYETQPVPNP IAYYLHRSPW WFHRFETLSN HFVELLVPFF LFLGRRMRIL HGVLQILFQV
310 320 330 340 350 360
ILIISGNLSF LNWLTIVPSL ACFDDAALGF LFPSGPQGLK KQVLEIQRED TQRVQPKPRD
370 380 390 400 410 420
RGCLVRQVVN ISLGILVAWL SVPVVINLLS SRQIMNTSFN PLRIVNTYGA FGSVTKERTE
430 440 450 460 470 480
VILQGTVSPN ASAPDAVWED YEFKCKPGDP WRQPCLISPY HYRLDWLMWF AAFQTYEQNE
490 500 510 520 530 540
WILHLAGKLL AGDSEALALL AVNPFEGRTP PRWIRGEHYR YKFSLPGGQH ATQGKWWIRK
550 560 570
RIGPYFPPLR LEDLKEYFKT REWPLPEPPS RHTR