Q3U3R4
Gene name |
Lmf1 (Tmem112) |
Protein name |
Lipase maturation factor 1 |
Names |
Transmembrane protein 112 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76483 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3U3R4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3U3R4-F1 | Predicted | AlphaFoldDB |
29 variants for Q3U3R4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389445567 | 26 | S>N | No | EVA | |
| rs260462643 | 32 | S>P | No | EVA | |
| rs3389453963 | 48 | T>I | No | EVA | |
| rs3389355660 | 51 | L>Q | No | EVA | |
| rs47831671 | 93 | N>T | No | EVA | |
| rs46488937 | 105 | A>T | No | EVA | |
| rs260972199 | 108 | T>I | No | EVA | |
| rs3389413453 | 110 | A>V | No | EVA | |
| rs265190596 | 113 | I>V | No | EVA | |
| rs3389355684 | 114 | M>V | No | EVA | |
| rs3389459414 | 123 | N>D | No | EVA | |
| rs244143086 | 136 | I>L | No | EVA | |
| rs3389435426 | 297 | L>P | No | EVA | |
| rs3389404413 | 298 | F>I | No | EVA | |
| rs3389422499 | 390 | S>N | No | EVA | |
| rs3389445549 | 429 | P>L | No | EVA | |
| rs3389444947 | 432 | S>I | No | EVA | |
| rs3389451149 | 433 | A>T | No | EVA | |
| rs13474912 | 442 | E>* | No | EVA | |
| rs3407863698 | 465 | D>E | No | EVA | |
| rs3406917146 | 465 | D>V | No | EVA | |
| rs3389392709 | 471 | A>T | No | EVA | |
| rs3389451073 | 472 | A>D | No | EVA | |
| rs233590091 | 482 | I>L | No | EVA | |
| rs3389453923 | 508 | R>K | No | EVA | |
| rs3389442563 | 518 | H>Y | No | EVA | |
| rs3389453881 | 528 | G>D | No | EVA | |
| rs3389392718 | 536 | W>L | No | EVA | |
| rs3389435498 | 540 | K>N | No | EVA |
1 associated diseases with Q3U3R4
Without disease ID
No regional properties for Q3U3R4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3U3R4 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| chylomicron remnant clearance | The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded. |
| endoplasmic reticulum to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. |
| positive regulation of lipoprotein lipase activity | Any process that activates or increases the activity of the enzyme lipoprotein lipase. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
| protein maturation | Any process leading to the attainment of the full functional capacity of a protein. |
| protein secretion | The controlled release of proteins from a cell. |
| regulation of cholesterol metabolic process | Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| regulation of triglyceride metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol. |
| triglyceride metabolic process | The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRPDSLVMAA | PEGSLRKRKV | GGAEHSPASQ | PSLARDPADS | PARLHTGTFW | LTRIVLLRAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AFIYFVAFLV | AFNQNKALIG | DRGLLPCKLY | LKNVQEYFQG | STGWAAWTYA | PTIMWLLDWS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DMNFNLDLIA | LLGLGISSFV | LVTGCANMIL | MTALWALYMS | LVNVGQIWYS | FGWESQLLET |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GFLGIFLSPL | WTLSRLPKNT | PTSQIVLWGF | RWLIFRIMLG | AGLIKVRGDK | CWLDLTCMDF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HYETQPVPNP | IAYYLHRSPW | WFHRFETLSN | HFVELLVPFF | LFLGRRMRIL | HGVLQILFQV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ILIISGNLSF | LNWLTIVPSL | ACFDDAALGF | LFPSGPQGLK | KQVLEIQRED | TQRVQPKPRD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RGCLVRQVVN | ISLGILVAWL | SVPVVINLLS | SRQIMNTSFN | PLRIVNTYGA | FGSVTKERTE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VILQGTVSPN | ASAPDAVWED | YEFKCKPGDP | WRQPCLISPY | HYRLDWLMWF | AAFQTYEQNE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WILHLAGKLL | AGDSEALALL | AVNPFEGRTP | PRWIRGEHYR | YKFSLPGGQH | ATQGKWWIRK |
| 550 | 560 | 570 | |||
| RIGPYFPPLR | LEDLKEYFKT | REWPLPEPPS | RHTR |