Q3TRM4

PR
Gene name
Pnpla6 (Nte)
Protein name
Patatin-like phospholipase domain-containing protein 6
Names
Neuropathy target esterase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:50767
EC number
3.1.1.5: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

71-143 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3TRM4

Entry ID Method Resolution Chain Position Source
AF-Q3TRM4-F1 Predicted AlphaFoldDB

No variants for Q3TRM4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3TRM4

No associated diseases with Q3TRM4

5 regional properties for Q3TRM4

Type Name Position InterPro Accession
domain Cyclic nucleotide-binding domain 179 - 306 IPR000595-1
domain Cyclic nucleotide-binding domain 492 - 612 IPR000595-2
domain Cyclic nucleotide-binding domain 615 - 731 IPR000595-3
conserved_site Lysophospholipase patatin, conserved site 964 - 996 IPR001423
domain Patatin-like phospholipase domain 961 - 1127 IPR002641

Functions

Description
EC Number 3.1.1.5 Carboxylic ester hydrolases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type III membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name Definition
carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond.
lysophospholipase activity Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
phosphatidyl phospholipase B activity Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate.

4 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IY17 PNPLA6 Patatin-like phospholipase domain-containing protein 6 Homo sapiens (Human) PR
Q02331 ZK370.4 Patatin-like phospholipase domain-containing protein ZK370.4 Caenorhabditis elegans PR
10 20 30 40 50 60
MGTPSHELNT TSSGAEVIQK TLEEGLGRRI CVAQPVPFVP QVLGVMIGAG VAVLVTAVLI
70 80 90 100 110 120
LLVVRRLRVQ KTPAPEGPRY RFRKRDKVLF YGRKIMRKVS QSTSSLVDTS VSTTSRPRMK
130 140 150 160 170 180
KKLKMLNIAK KILRIQKETP TLQRKEPPPS VLEADLTEGD LANSHLPSEV LYMLKNVRVL
190 200 210 220 230 240
GHFEKPLFLE LCRHMVFQRL GQGDYVFRPG QPDASIYVVQ DGLLELCLPG PDGKECVVKE
250 260 270 280 290 300
VVPGDSVNSL LSILDVITGH QHPQRTVSAR AARDSTVLRL PVEAFSAVFT KYPESLVRVV
310 320 330 340 350 360
QIIMVRLQRV TFLALHNYLG LTNELFSHEI QPLRLFPSPG LPTRTSPVRG SKRVVSTSGT
370 380 390 400 410 420
EDTSKETSGR PLDSIGAPLP GPAGDPVKPT SLEAPPAPLL SRCISMPVDI SGLQGGPRSD
430 440 450 460 470 480
FDMAYERGRI SVSLQEEASG GPQTASPREL REQPAGACEY SYCEDESATG GCPFGPYQGR
490 500 510 520 530 540
QTSSIFEAAK RELAKLMRIE DPSLLNSRVL LHHAKAGTII ARQGDQDVSL HFVLWGCLHV
550 560 570 580 590 600
YQRMIDKAEE VCLFVAQPGE LVGQLAVLTG EPLIFTLRAQ RDCTFLRISK SHFYEIMRAQ
610 620 630 640 650 660
PSVVLSAAHT VAARMSPFVR QMDFAIDWTA VEAGRALYRQ GDRSDCTYIV LNGRLRSVIQ
670 680 690 700 710 720
RGSGKKELVG EYGRGDLIGV VEALTRQPRA TTVHAVRDTE LAKLPEGTLG HIKRRYPQVV
730 740 750 760 770 780
TRLIHLLSQK ILGNLQQLQG PFPGSGLSVP QHSELTNPAS NLSTVAILPV CAEVPMMAFT
790 800 810 820 830 840
LELQHALQAI GPTLLLNSDV IRALLGASAL DSIQEFRLSG WLAQQEDAHR IVLYQTDTSL
850 860 870 880 890 900
TPWTVRCLRQ ADCILIVGLG DQEPTVGQLE QMLENTAVRA LKQLVLLHRE EGPGPTRTVE
910 920 930 940 950 960
WLNMRSWCSG HLHLRCPRRL FSRRSPAKLH ELYEKVFSRR ADRHSDFSRL ARVLTGNTIA
970 980 990 1000 1010 1020
LVLGGGGARG CSHIGVLKAL EEAGVPVDLV GGTSIGSFIG ALYAEERSAS RTKQRAREWA
1030 1040 1050 1060 1070 1080
KSMTSVLEPV LDLTYPVTSM FTGSAFNRSI HRVFQDKQIE DLWLPYFNVT TDITASAMRV
1090 1100 1110 1120 1130 1140
HKDGSLWRYV RASMTLSGYL PPLCDPKDGH LLMDGGYINN LPADIARSMG AKTVIAIDVG
1150 1160 1170 1180 1190 1200
SQDETDLSTY GDSLSGWWLL WKRLNPWADK VKVPDMAEIQ SRLAYVSCVR QLEVVKSSSY
1210 1220 1230 1240 1250 1260
CEYLRPSIDC FKTMDFGKFD QIYDVGYQYG KAVFGGWTRG EVIEKMLTDR RSTDLNESRR
1270 1280 1290 1300 1310 1320
ADILAFPSSG FTDLAEIVSR IEPPTSYVSD GCADGEESDC LTEYEEDAGP DCSRDEGGSP
1330 1340 1350
EGASPSTASE VEEEKSTLRQ RRFLPQETPS SVADA