Q02331

PR
Gene name
ZK370.4
Protein name
Patatin-like phospholipase domain-containing protein ZK370.4
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_ZK370.4
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1297-1353 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q02331

Entry ID Method Resolution Chain Position Source
AF-Q02331-F1 Predicted AlphaFoldDB

No variants for Q02331

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q02331

No associated diseases with Q02331

5 regional properties for Q02331

Type Name Position InterPro Accession
domain Cyclic nucleotide-binding domain 238 - 373 IPR000595-1
domain Cyclic nucleotide-binding domain 449 - 570 IPR000595-2
domain Cyclic nucleotide-binding domain 570 - 690 IPR000595-3
conserved_site Lysophospholipase patatin, conserved site 945 - 977 IPR001423
domain Patatin-like phospholipase domain 942 - 1108 IPR002641

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
lysophospholipase activity Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

2 GO annotations of biological process

Name Definition
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IY17 PNPLA6 Patatin-like phospholipase domain-containing protein 6 Homo sapiens (Human) PR
Q3TRM4 Pnpla6 Patatin-like phospholipase domain-containing protein 6 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSFFYSLFAP LIFLVTFIYN HVLLILFTVC IIGAAAFFVS YYLFGYSNTP SSASSSATPS
70 80 90 100 110 120
SRNSPNKERS KKVPTILETD NEDDEIRVNG SPKSGTPTNT QTIEPPTSLN LNMVNSASGS
130 140 150 160 170 180
NLSGARRMRK RDWAKKLYKS LVQDSPGRTP TDESSDEENA NVVMGGGSVP RRRSKHGNSS
190 200 210 220 230 240
RRRQSTAFQL AKDLIRRGSR SYFRQNQENN KDTRVRPPQE FFEPTDLPEI PQNLQPEIFY
250 260 270 280 290 300
ILHNLKMLEL PSEWKLDPRE IEVRSFQAGD YIVKPGESDD AIYVAIDGEL TVHIRHMEGK
310 320 330 340 350 360
EYLVKCIPAG GSFFSLLSML DILMDFPSIF RTVALKAADP CRVAKFPITS FRESYHKNPE
370 380 390 400 410 420
AWIRPIQIVI TRLLHVTLTT LHQYMGLSSE LMRRRRDDDR HRNGSSTSKL QLSLSLKKKE
430 440 450 460 470 480
KPFNINDNEQ DQLIVARKWM AEAFGLVADD VVSEQIGSKI HLESYEAGHV IIEQGAEEEV
490 500 510 520 530 540
LMMVLHGNLI LAQYGSDFFA QIERESLFDE ENNEEDESAV IRVTARELVG GLQILTNEPS
550 560 570 580 590 600
FYTIRAAVQT RVAIMKKKDF SAFLEAHPEI YLPVAHSVLR RLSPFLRGVD FALDWVLVDS
610 620 630 640 650 660
GHACYRAGDM ADSLFVVLSG RLRSVEKKTV VEEFGRGDVL GMMEVLTKKP RATTVLAVRF
670 680 690 700 710 720
SQLARVPEGL LNFIKMQYPQ VGFRLVQLLG QYYSQTNRRA PFAAPTVIRT NELGATDPMS
730 740 750 760 770 780
HIKNLHTIAV VPASPDVPLV PFTCELYHAL SSNLRVLRLS SQKVAACLDP SVLEKQADFR
790 800 810 820 830 840
LMHWLNVQED TYPLVIYECD FTQTNWTRRC LRQADAILVV AIGGKTPEKQ TLMRELMNMN
850 860 870 880 890 900
QDGVRTNKEL ILLWPESTKT PSGTIEWLKN SYFSGHHHIR APKRMLQWNR KFRKMSRAEV
910 920 930 940 950 960
MTPTSVENEV IEYYEKNVFW TPDRRSDFSR LARILTGNAI GLVLGGGGAR GAAHVGVLRA
970 980 990 1000 1010 1020
LREEGIPVDI VGGTSIGSLI GGLYAETPDD VVVETRAASW FNGMSSLWRK LLDLTYAHSA
1030 1040 1050 1060 1070 1080
MFTGAQFNFS IKDLFEERLI EDLWISYFCI STDISTSEMR VHRSGPLWAY CRASMSLAGY
1090 1100 1110 1120 1130 1140
LPPLCDPQDG HLLLDGGYVN NVPADVMRNL GARCVIACDV GSIEETNLYD YGDSLSGMWV
1150 1160 1170 1180 1190 1200
LLKRLNPFGT PPRILNMEEI QSRLAYVSCV RQLEVVKKAS YCRYLRPPIE PFKTLDFPKF
1210 1220 1230 1240 1250 1260
QEIMELGLKY GREACHELIT NDRAGILGDE KETRKFKRQQ SRREKPDVSR AVSFTDLAAA
1270 1280 1290 1300 1310 1320
MSKIPVVRPT LRHSMSLNPS ANGPVGRAGD HFLLDDDLFN DTDYYEEESS QSENGNESFT
1330 1340 1350
EDEDLVIGPP SSSSSGGNVS ENPRGTTPRP PSS