Q3TLD5
PR
Gene name |
Uri1 (Nnx3, Ppp1r19, Rmp, Uri) |
Protein name |
Unconventional prefoldin RPB5 interactor |
Names |
Protein NNX3, Protein phosphatase 1 regulatory subunit 19, RNA polymerase II subunit 5-mediating protein, RPB5-mediating protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19777 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3TLD5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3TLD5-F1 | Predicted | AlphaFoldDB |
23 variants for Q3TLD5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs241088674 | 10 | E>Q | No | EVA | |
| rs3388902801 | 90 | H>Q | No | EVA | |
| rs3388889567 | 91 | T>I | No | EVA | |
| rs3388894881 | 115 | V>D | No | EVA | |
| rs3388897538 | 147 | Q>* | No | EVA | |
| rs238956007 | 201 | N>D | No | EVA | |
| rs3388899151 | 246 | K>M | No | EVA | |
| rs3388906087 | 252 | G>D | No | EVA | |
| rs216168760 | 271 | R>H | No | EVA | |
| rs3388901829 | 272 | A>V | No | EVA | |
| rs31138105 | 306 | E>D | No | EVA | |
| rs586929126 | 318 | N>S | No | EVA | |
| rs242384693 | 326 | A>S | No | EVA | |
| rs3388902781 | 365 | R>W | No | EVA | |
| rs3397843966 | 382 | I>V | No | EVA | |
| rs3397783989 | 432 | R>L | No | EVA | |
| rs3397853212 | 433 | G>V | No | EVA | |
| rs3388905175 | 455 | E>G | No | EVA | |
| rs3397398255 | 468 | G>* | No | EVA | |
| rs3388899148 | 478 | I>V | No | EVA | |
| rs230919180 | 490 | Y>H | No | EVA | |
| rs212193109 | 511 | V>A | No | EVA | |
| rs3388903094 | 524 | A>T | No | EVA |
No associated diseases with Q3TLD5
No regional properties for Q3TLD5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3TLD5 | |||
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RPAP3/R2TP/prefoldin-like complex | A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| phosphatase inhibitor activity | Binds to and stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. |
| phosphoprotein binding | Binding to a phosphorylated protein. |
| protein phosphatase inhibitor activity | Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. |
| RNA polymerase II complex binding | Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. |
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. |
| cellular response to steroid hormone stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. |
| negative regulation of intrinsic apoptotic signaling pathway | Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. |
| negative regulation of phosphatase activity | Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of cell growth | Any process that modulates the frequency, rate, extent or direction of cell growth. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to virus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPPSEPEPE | PQPLAEASAA | APLRAPEVAR | LREEQEKVVT | NCQEKIQHWE | KVDNDYSALQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ERLRTLPDKL | SYDVMVPFGP | LAFMPGKLVH | TNEVTVLLGD | NWFAKCSAKQ | AVGLVEHRKE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HVRKTIDDFK | KVLKNFESRV | EFTEDLQKMS | DAAGDFVDIR | EEIKSDFEFK | GKQRIAHKPH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SKPKTSDIFE | ADFENGVKPK | NTFDADELWA | RLEELERQEE | LLGELESKPD | TVIANGEDRV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSEEEKEGAD | TGVNVVSPVT | DSSAASSCKR | RAGNAGLPNG | QVNSLNYSVN | GSNSYHSNKD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DDEEEEDDDD | DDDEDDDNES | DHAISADNSI | PTIYFSHTVE | PKRVRINTGK | NTTLKFSEKK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EEAKRKRKSG | AGSHATHELP | AIKSPADIYR | VFVDVVNGEY | VPRKSILKSR | SRENSVCSDT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SESSAADVED | RRGLLRSTSS | EEAVATEAGG | SSLDELQENH | PKKPLPSGVS | EAFSGTVIEK |
| 490 | 500 | 510 | 520 | 530 | |
| EFLSPSLAPY | SAIAHHALPT | IPERKEVPSE | VSEEPTKRVS | KFRAARLQQR | S |