AiPD: Autoinhibited Protein Database

O94763

Gene name	URI1 (C19orf2, NNX3, PPP1R19, RMP, URI)
Protein name	Unconventional prefoldin RPB5 interactor 1
Names	Protein NNX3, Protein phosphatase 1 regulatory subunit 19, RNA polymerase II subunit 5-mediating protein, RPB5-mediating protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8725
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-70 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O94763

Entry ID	Method	Resolution	Chain	Position	Source
AF-O94763-F1	Predicted				AlphaFoldDB

496 variants for O94763

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA405140587 rs1236599761	2	E>*		No	ClinGen gnomAD
CA405140598 rs1215776464	3	A>V		No	ClinGen TOPMed
TCGA novel	4	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405140620 rs1272789107	7	E>A		No	ClinGen TOPMed
CA405140623 rs1189543395	7	E>D		No	ClinGen TOPMed gnomAD
CA405140630 rs1318836334	8	T>M		No	ClinGen TOPMed
CA405140633 rs1242462636	9	P>A		No	ClinGen TOPMed
rs1418351083 CA405140636	9	P>L		No	ClinGen gnomAD
CA405140632 rs1242462636	9	P>S		No	ClinGen TOPMed
rs942167206 CA306818110	10	P>H		No	ClinGen TOPMed gnomAD
CA306818119 rs942167206	10	P>L		No	ClinGen TOPMed gnomAD
rs746162017 CA9352490	10	P>S		No	ClinGen ExAC gnomAD
CA405140644 rs1292611943	11	D>G		No	ClinGen TOPMed
CA306818126 rs993558337	11	D>N		No	ClinGen TOPMed
rs551935451 CA405140648	12	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA306818187 rs1013336536	12	P>L		No	ClinGen TOPMed gnomAD
CA9352494 rs551935451	12	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA405140647 rs551935451	12	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9352495 rs763524587	13	S>*		No	ClinGen ExAC gnomAD
CA405140654 rs1390372356	13	S>P		No	ClinGen gnomAD
CA405140672 rs1228130868	14	P>L		No	ClinGen TOPMed gnomAD
CA405140666 rs1356554097	14	P>S		No	ClinGen gnomAD
CA405140679 rs1266883583	15	P>L		No	ClinGen TOPMed
CA9352496 rs763718000	15	P>S		No	ClinGen ExAC TOPMed gnomAD
CA405140686 rs1313875784	16	S>L		No	ClinGen TOPMed gnomAD
CA405140684 rs1451315142	16	S>P		No	ClinGen Ensembl
rs773692912 CA9352498	17	A>V		No	ClinGen ExAC gnomAD
CA9352499 rs761530942	18	P>A		No	ClinGen ExAC gnomAD
CA405140706 rs1484382994	18	P>R		No	ClinGen gnomAD
rs1257755459 CA405140716	19	A>S		No	ClinGen TOPMed gnomAD
rs1257755459 CA405140712	19	A>T		No	ClinGen TOPMed gnomAD
CA405140721 rs1236164838	19	A>V		No	ClinGen TOPMed
rs750072934 CA9352502	20	P>S		No	ClinGen ExAC gnomAD
rs969075996 CA306818245	21	A>P		No	ClinGen TOPMed
CA405140730 rs969075996	21	A>T		No	ClinGen TOPMed
CA9352503 rs189187 VAR_056978	22	L>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1599656384 CA405140754	23	V>G		No	ClinGen Ensembl
CA9352505 rs753819220	23	V>L		No	ClinGen ExAC TOPMed gnomAD
CA9352506 rs754863175	24	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1377461074 CA405140755	24	P>T		No	ClinGen TOPMed
rs777942561 CA405140766	25	L>S		No	ClinGen ExAC gnomAD
CA9352507 rs777942561	25	L>W		No	ClinGen ExAC gnomAD
rs757515487 CA9352509	27	A>G		No	ClinGen ExAC gnomAD
CA9352508 rs746997794	27	A>S		No	ClinGen ExAC gnomAD
rs531169826 CA9352511	28	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9352514 rs12984378	29	D>E		No	ClinGen ExAC TOPMed gnomAD
CA405140810 rs12977890	29	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9352512 rs770324421	29	D>N		No	ClinGen ExAC TOPMed gnomAD
rs12977890 CA9352513	29	D>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773924540 CA9352516	31	A>T		No	ClinGen ExAC
rs761282463 CA9352517	32	R>W		No	ClinGen ExAC gnomAD
CA405140845 rs1342587529	33	L>V		No	ClinGen TOPMed
rs1193648880 CA405140851	34	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA405140852 rs1252442263	34	R>L		No	ClinGen gnomAD
CA9352519 rs772777085	35	E>D		No	ClinGen ExAC gnomAD
CA405140897 rs1251022155	36	E>G		No	ClinGen gnomAD
CA9352520 rs760295998	38	E>G		No	ClinGen ExAC gnomAD
rs1460919277 CA405140936	39	K>T		No	ClinGen TOPMed gnomAD
CA9352553 rs754107926	40	V>M		No	ClinGen ExAC TOPMed gnomAD
CA306831752 rs982041570	41	V>F		No	ClinGen Ensembl
rs1233849223 CA405143354	42	T>A		No	ClinGen TOPMed gnomAD
rs755338534 CA9352554	44	C>Y		No	ClinGen ExAC gnomAD
rs779312870 CA9352555	45	Q>*		No	ClinGen ExAC gnomAD
rs748622875 CA9352556	45	Q>R		No	ClinGen ExAC gnomAD
CA306831760 rs926645667	46	E>K		No	ClinGen Ensembl
CA405143446 rs1447814505	47	R>T		No	ClinGen gnomAD
TCGA novel	52	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747510327 CA9352584	52	K>Q		No	ClinGen ExAC gnomAD
rs894143952 CA306837649	54	V>G		No	ClinGen TOPMed
CA405145776 rs1458501594	55	D>E		No	ClinGen TOPMed gnomAD
CA9352585 rs756805150	56	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1043994721 CA306837654	56	N>S		No	ClinGen TOPMed
CA405145809 rs1289038190	57	D>E		No	ClinGen gnomAD
CA405145805 rs1278528881	57	D>G		No	ClinGen gnomAD
rs780661066 CA9352586	58	Y>C	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA405145881 rs1251134751	62	R>G		No	ClinGen gnomAD
rs745532513 CA9352587	62	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	64	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1179516967 CA405145928	65	L>F		No	ClinGen gnomAD
CA405145967 rs1251836657	66	S>T		No	ClinGen gnomAD
CA405146070 rs1241751277	71	K>Q		No	ClinGen Ensembl
CA9352589 rs775159256	71	K>R		No	ClinGen ExAC gnomAD
TCGA novel	75	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	77	M>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	78	V>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9352624 rs765228231	78	V>I		No	ClinGen ExAC TOPMed gnomAD
CA405146940 rs765228231	78	V>L		No	ClinGen ExAC TOPMed gnomAD
rs775821792 CA9352625	79	P>L		No	ClinGen ExAC gnomAD
CA405146958 rs1232026703	80	F>I		No	ClinGen gnomAD
rs1012431680 CA306838133	83	F>V		No	ClinGen gnomAD
rs757772188 CA9352629	84	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1426620103 CA405146991	84	A>V		No	ClinGen gnomAD
CA9352630 rs768125314	86	M>L		No	ClinGen ExAC gnomAD
rs750887254 CA9352631	87	P>S		No	ClinGen ExAC gnomAD
CA306838148 rs750887254	87	P>T		No	ClinGen ExAC gnomAD
rs377763176 CA9352632	90	L>P		No	ClinGen ESP ExAC gnomAD
rs867728868 CA306838160	93	T>N		No	ClinGen Ensembl
rs1311748590 CA405147063	94	N>S		No	ClinGen TOPMed
CA306838163 rs996185017	96	V>I		No	ClinGen Ensembl
rs1418483482 CA405147098	97	T>S		No	ClinGen gnomAD
rs145433944 CA9352634	100	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA9352636 rs371470043	101	G>R		No	ClinGen ESP ExAC gnomAD
CA9352638 rs747895169	102	D>N		No	ClinGen ExAC gnomAD
rs754569782	102	D>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs771980248 CA9352640	103	N>S		No	ClinGen ExAC gnomAD
rs1357688874 CA405147163	104	W>*		No	ClinGen gnomAD
CA9352641 rs777834835	105	F>I		No	ClinGen ExAC gnomAD
CA405147191 rs1318145511	107	K>E		No	ClinGen TOPMed gnomAD
CA9352643 rs769970139	107	K>T		No	ClinGen ExAC gnomAD
CA405147225 rs1451429639	110	A>T		No	ClinGen gnomAD
rs929285963 CA306838190	112	Q>*		No	ClinGen TOPMed
CA9352646 rs768801845	113	A>G		No	ClinGen ExAC gnomAD
CA405147262 rs1257899587	113	A>P		No	ClinGen TOPMed gnomAD
TCGA novel	113	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405147260 rs1257899587	113	A>T		No	ClinGen TOPMed gnomAD
rs370568674 CA405147279	115	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9352648 rs149206403	115	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA9352647 rs370568674	115	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs149206403 CA9352649	115	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA405147286 rs112541086	116	L>I		No	ClinGen TOPMed
CA405147320 rs188951746 CA9352652	118	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1452789507 CA405147323	119	H>N		No	ClinGen TOPMed
rs753330651 CA9352653	119	H>R		No	ClinGen ExAC TOPMed gnomAD
rs754690097 CA9352654	120	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA306838230 rs1057098287	120	R>W		No	ClinGen TOPMed gnomAD
rs778768580 CA9352655	121	K>Q		No	ClinGen ExAC gnomAD
CA405147367 rs1288585465	122	E>D		No	ClinGen TOPMed
CA9352659 rs200364419	123	H>D		No	ClinGen ExAC TOPMed gnomAD
CA306821625 rs1036522223	123	H>L		No	ClinGen TOPMed gnomAD
CA405145593 rs1036522223	123	H>R		No	ClinGen TOPMed gnomAD
rs200364419 CA9352657	123	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1323883096 CA405145600	124	V>I		No	ClinGen gnomAD
CA9352685 rs200596493	125	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA405145631 rs1470187859	126	K>R		No	ClinGen TOPMed
CA9352686 rs772118177	129	D>G		No	ClinGen ExAC gnomAD
rs1318267240 CA405145681	130	D>G		No	ClinGen TOPMed gnomAD
rs1232653363 CA405145726	131	L>F		No	ClinGen gnomAD
CA9352687 rs200193659	132	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA9352688 rs747390009	133	K>T		No	ClinGen ExAC TOPMed
rs1568443871	134	V>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1467248906 CA405145781	134	V>L		No	ClinGen gnomAD
rs201965478 CA9352689	135	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201965478 CA9352690	135	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1268077881 CA405145832	136	K>R		No	ClinGen TOPMed gnomAD
CA405145829 rs1268077881	136	K>T		No	ClinGen TOPMed gnomAD
CA9352691 rs199910353	137	N>S		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	138	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	138	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405145897 rs1568443910	139	E>K		No	ClinGen Ensembl
rs1265829030 CA405145958	140	S>F		No	ClinGen gnomAD
CA405145966 rs1385654392	141	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1164885403 CA405145992	142	V>I		No	ClinGen TOPMed gnomAD
CA9352692 rs201586355	143	E>Q		No	ClinGen ExAC gnomAD
rs1056250739 CA306821655	144	F>I		No	ClinGen TOPMed gnomAD
CA405146058 rs1163333249	145	T>P		No	ClinGen gnomAD
TCGA novel	146	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762675293 CA9352694	147	D>G		No	ClinGen ExAC gnomAD
rs553078220 CA9352695	148	L>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751214399 CA9352696	150	K>R		No	ClinGen ExAC gnomAD
CA405146258 CA405146257 rs767273785	152	S>R		No	ClinGen ExAC TOPMed gnomAD
CA9352700 rs545234427	153	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778969221 CA9352701	153	D>V		No	ClinGen ExAC TOPMed gnomAD
rs545234427 CA9352699	153	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs143348334 CA405146425	154	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143348334 CA405146428	154	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143348334 CA9352723	154	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA405146464 rs1394871675	156	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA9352726 rs751752972	157	D>V		No	ClinGen ExAC
CA405146503 rs1204354808	158	I>F		No	ClinGen gnomAD
CA405146518 rs1179983818	158	I>M		No	ClinGen TOPMed gnomAD
rs373724542 CA9352727	158	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1380308911 CA405146561	160	D>V		No	ClinGen gnomAD
rs781696245 CA9352728	161	I>V		No	ClinGen ExAC gnomAD
CA405146600 rs746182493	162	R>P		No	ClinGen ExAC TOPMed gnomAD
CA9352729 rs746182493	162	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1486036777 CA405146610	163	E>*		No	ClinGen TOPMed
CA405146693 rs1479341365	166	K>N		No	ClinGen TOPMed gnomAD
CA9352730 rs148342810	167	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs148342810 CA405146710	167	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA306821851 rs749777203	170	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9352732 rs749777203	170	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA9352752 rs769137217	174	K>E		No	ClinGen ExAC TOPMed gnomAD
rs778299485 CA9352753	175	H>L		No	ClinGen ExAC gnomAD
CA9352754 rs747714196	175	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs771563788 CA9352755	176	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772890952 CA9352756	176	R>L		No	ClinGen ExAC TOPMed gnomAD
CA306822898 rs772890952	176	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs770656465 CA9352758	177	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	178	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9352759 rs776447992	179	H>R		No	ClinGen ExAC gnomAD
rs1478660014 CA405147146	179	H>Y		No	ClinGen gnomAD
rs137929297 CA9352761	181	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs145377110 CA9352760	181	P>S		No	ClinGen ESP ExAC gnomAD
CA9352763 rs762053490	182	H>Y		No	ClinGen ExAC gnomAD
rs767677021 CA9352764	185	P>L		No	ClinGen ExAC gnomAD
CA405147264 rs1288489987	186	K>E		No	ClinGen TOPMed gnomAD
rs750691974 CA9352766	187	T>A		No	ClinGen ExAC TOPMed gnomAD
rs750691974 CA9352765	187	T>S		No	ClinGen ExAC TOPMed gnomAD
rs766654829 CA9352767	189	D>A		No	ClinGen ExAC gnomAD
rs201389473 CA405147324	190	I>N		No	ClinGen 1000Genomes ExAC gnomAD
rs201389473 CA9352768	190	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA405147340 rs1227041233	191	F>L		No	ClinGen gnomAD
CA405147370 rs1291427726	193	A>G		No	ClinGen gnomAD
CA9352769 rs755283442	194	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA306822961 rs190941585	195	I>T		No	ClinGen 1000Genomes gnomAD
rs77744376 CA306822966	196	A>S		No	ClinGen 1000Genomes gnomAD
CA9352771 rs748622260	197	N>D		No	ClinGen ExAC gnomAD
rs757953945 CA9352772	197	N>S		No	ClinGen ExAC gnomAD
rs35808349 CA9352773	198	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA306822980 rs1034068395	198	D>N		No	ClinGen Ensembl
rs1043422475 CA306822985	201	S>Y		No	ClinGen TOPMed
CA405147487 rs984305445	202	K>E		No	ClinGen TOPMed gnomAD
CA306822987 rs984305445	202	K>Q		No	ClinGen TOPMed gnomAD
CA9352775 rs770552592	205	L>P		No	ClinGen ExAC TOPMed gnomAD
rs746696922 CA9352774	205	L>V		No	ClinGen ExAC gnomAD
rs776307122 CA9352776	206	A>G		No	ClinGen ExAC gnomAD
rs1017556157 CA306822998	209	E>K		No	ClinGen Ensembl
CA405147612 rs1450997889	210	L>P		No	ClinGen gnomAD
rs369899938 CA306823003	213	R>*		No	ClinGen ESP TOPMed
rs769475335 CA9352778	213	R>L		No	ClinGen ExAC TOPMed gnomAD
CA9352779 rs769475335	213	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs767732282 CA9352781	215	E>G		No	ClinGen ExAC gnomAD
CA9352780 rs762932076	215	E>K		No	ClinGen ExAC gnomAD
rs892035685 CA306823018	216	E>K		No	ClinGen TOPMed gnomAD
CA9352782 rs773357097	217	L>R		No	ClinGen ExAC
rs760817697 CA9352784	220	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA9352785 rs766679979	220	Q>R		No	ClinGen ExAC
rs754000804 CA9352786	221	E>Q		No	ClinGen ExAC gnomAD
CA9352788 rs765496747	223	L>F		No	ClinGen ExAC TOPMed gnomAD
CA405147722 rs1237982024	227	L>H		No	ClinGen gnomAD
rs1176707994 CA405147725	228	D>Y		No	ClinGen gnomAD
CA405147732 rs1294004282	229	S>G		No	ClinGen gnomAD
CA9352801 rs749238754	231	P>S		No	ClinGen ExAC gnomAD
CA405148299 rs749238754	231	P>T		No	ClinGen ExAC gnomAD
CA9352803 rs548314725	232	D>G		No	ClinGen ExAC TOPMed gnomAD
CA9352802 rs548314725	232	D>V		No	ClinGen ExAC TOPMed gnomAD
CA279234 RCV000201379 rs863223392	233	T>I		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs770885228 CA9352805	236	A>T		No	ClinGen ExAC
CA9352807 rs776960995	237	N>D		No	ClinGen ExAC gnomAD
rs1438087517 CA405148338	237	N>S		No	ClinGen gnomAD
CA306823582 rs1007269455	238	G>R		No	ClinGen TOPMed
CA9352809 rs759629218	240	D>N		No	ClinGen ExAC TOPMed gnomAD
rs963007878 CA306823591	241	T>M		No	ClinGen TOPMed gnomAD
TCGA novel	241	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1198711718 CA405148380	244	S>P		No	ClinGen TOPMed
rs765622461 CA9352810	245	E>G		No	ClinGen ExAC gnomAD
rs752995238 CA9352811	247	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1201327388 CA405148416	249	E>*		No	ClinGen gnomAD
rs763464960 CA9352812	249	E>G		No	ClinGen ExAC gnomAD
rs1247705925 CA405148425	250	D>G		No	ClinGen gnomAD
rs764646236 CA9352813	250	D>Y		No	ClinGen ExAC gnomAD
rs373823921 CA9352814	251	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA9352815 rs756836475	251	R>H		No	ClinGen ExAC TOPMed gnomAD
CA9352816 rs780549472	252	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1475597277 CA405148444	253	T>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs150496764 CA9352817	255	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA405148470 rs138648155	257	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs138648155 CA9352818	257	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA405148476 rs1388179006	258	M>T		No	ClinGen gnomAD
rs1409258435 CA405148484	259	H>P		No	ClinGen TOPMed
TCGA novel	260	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749149659 CA9352820	261	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1165213845 CA405148503	262	T>A		No	ClinGen TOPMed
CA405148515 rs1325704849	263	D>E		No	ClinGen gnomAD
CA306823635 rs1051437501	265	H>R		No	ClinGen gnomAD
rs768566007 CA9352821	265	H>Y		No	ClinGen ExAC gnomAD
rs1232561088 CA405148533	266	T>I		No	ClinGen gnomAD
rs1178794281 CA405148545	268	C>F		No	ClinGen TOPMed
CA9352823 rs779032285	269	H>P		No	ClinGen ExAC gnomAD
rs1481336543 CA405148550	269	H>Y		No	ClinGen TOPMed
CA9352824 rs748013549	271	D>V		No	ClinGen ExAC gnomAD
CA306823649 rs888876093	272	V>A		No	ClinGen TOPMed gnomAD
CA405148573 rs888876093	272	V>D		No	ClinGen TOPMed gnomAD
CA405148570 rs1211898672	272	V>I		No	ClinGen TOPMed gnomAD
rs112774025 CA9352825	273	A>P		No	ClinGen ExAC TOPMed gnomAD
CA306823653 rs112774025	273	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1039874668 CA306823656	274	S>N		No	ClinGen Ensembl
CA405148584 rs1400204759	274	S>R		No	ClinGen Ensembl
rs1478454502 CA405148614	279	S>R		No	ClinGen gnomAD
TCGA novel	280	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9352827 rs759809910	281	Q>*		No	ClinGen ExAC gnomAD
CA306823673 rs148462749	283	N>H		No	ClinGen ESP TOPMed gnomAD
rs769948220 CA405148663	285	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA9352829 rs775678023	286	L>F		No	ClinGen ExAC gnomAD
rs371310852 CA9352830	288	C>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA9352832 rs752161061	289	S>L		No	ClinGen ExAC TOPMed gnomAD
CA405148700 rs1441449831	291	N>S		No	ClinGen TOPMed
CA9352834 rs376103188	292	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9352833 rs376103188	292	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1346190598 CA405148719	294	S>I		No	ClinGen TOPMed gnomAD
CA405148722 rs1310446292	295	S>T		No	ClinGen gnomAD
rs926723943 CA306823706	296	Y>C		No	ClinGen TOPMed
CA306823710 rs936653581	297	H>Y		No	ClinGen TOPMed
rs200466034 CA306823759	299	D>G		No	ClinGen Ensembl
CA405148760 rs1599726216	300	D>G		No	ClinGen Ensembl
CA405148769 rs1287136418	301	D>G		No	ClinGen TOPMed
rs1490293835 CA405148765	301	D>N		No	ClinGen TOPMed
CA405148786 rs1218258166	303	D>G		No	ClinGen TOPMed
rs1218258166 CA405148787	303	D>V		No	ClinGen TOPMed
rs1052116322 CA306823769	303	D>Y		No	ClinGen TOPMed
TCGA novel	304	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755670302 CA9352845	305	D>G		No	ClinGen ExAC gnomAD
CA306823789 rs113183389	307	D>E		No	ClinGen 1000Genomes ExAC TOPMed
CA9352853 rs753508308	308	D>G		No	ClinGen ExAC gnomAD
rs1599726385 CA405148820	308	D>N		No	ClinGen Ensembl
TCGA novel	309	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9352856 rs748149375	309	D>G		No	ClinGen ExAC gnomAD
rs778801300 CA9352855	309	D>N		No	ClinGen ExAC TOPMed gnomAD
CA405148836 rs1480376780	310	D>G		No	ClinGen TOPMed
rs781346860 CA9352858	310	D>N		No	ClinGen ExAC TOPMed gnomAD
CA405148834 rs781346860	310	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs769862941 CA9352861	311	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	311	D>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9352862 rs775731438	312	N>D		No	ClinGen ExAC TOPMed gnomAD
CA9352863 rs749493622	312	N>S		No	ClinGen ExAC gnomAD
rs1337508378 CA405148855	313	I>N		No	ClinGen TOPMed gnomAD
rs1337508378 CA405148857	313	I>T		No	ClinGen TOPMed gnomAD
CA306823831 rs763315367	313	I>V		No	ClinGen TOPMed gnomAD
CA405148863 rs1599726470	314	D>G		No	ClinGen Ensembl
CA9352866 rs188172144	316	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA405148906 rs1232997738	320	N>D		No	ClinGen gnomAD
TCGA novel	320	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1428706394 CA405148919	321	D>E		No	ClinGen gnomAD
CA306823843 rs983016660	321	D>N		No	ClinGen TOPMed gnomAD
CA9352868 rs773761081	322	H>R		No	ClinGen ExAC gnomAD
CA405148922 rs1568447062	322	H>Y		No	ClinGen Ensembl
rs1456046009 CA405148929	323	E>G		No	ClinGen gnomAD
CA9352869 rs145352288	323	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA306823846 rs145352288	323	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	323	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs151025990 CA9352870	324	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA405148941 rs1380516222	325	L>S		No	ClinGen gnomAD
CA9352871 rs753567522	327	V>A		No	ClinGen ExAC gnomAD
CA9352872 rs540138830	330	N>D		No	ClinGen 1000Genomes ExAC gnomAD
CA9352875 rs758201066	332	I>T		No	ClinGen ExAC TOPMed gnomAD
CA9352874 rs201534752	332	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777640300 CA9352876	333	P>L		No	ClinGen ExAC gnomAD
CA9352877 rs746921538	335	I>V		No	ClinGen ExAC TOPMed gnomAD
rs756237766 CA9352878	336	Y>H		No	ClinGen ExAC gnomAD
rs1374328459 CA405149007	336	Y>S		No	ClinGen gnomAD
rs1386384116 CA405149031	339	H>R		No	ClinGen gnomAD
rs1374135298 CA405149035	340	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
TCGA novel	340	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1299668206 CA405149061	344	K>E		No	ClinGen gnomAD
TCGA novel	346	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748378354 CA9352904	347	R>*		No	ClinGen ExAC gnomAD
TCGA novel	347	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405149098 rs1488720868	347	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1192668290 CA405149119	350	T>I		No	ClinGen gnomAD
CA405149222 rs1172225795	364	E>A		No	ClinGen TOPMed
rs1475906011 CA405149225	364	E>D		No	ClinGen TOPMed
CA9352908 rs778158912	367	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs747521758 CA9352909	367	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA405149254 rs1222781830	369	R>*		No	ClinGen TOPMed gnomAD
CA306824750 rs771507685	369	R>L		No	ClinGen ExAC gnomAD
CA9352910 rs771507685	369	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1298006709 CA405149269	371	N>I		No	ClinGen TOPMed gnomAD
CA9352911 rs777265326	372	S>G		No	ClinGen ExAC TOPMed gnomAD
CA405149290 rs1402454031	374	G>V		No	ClinGen TOPMed gnomAD
rs1271256746 CA405149292	375	S>G		No	ClinGen gnomAD
rs1377900049 CA405149295	375	S>I		No	ClinGen gnomAD
rs759185458 CA405149302	376	G>A		No	ClinGen ExAC gnomAD
rs759185458 CA9352912	376	G>D		No	ClinGen ExAC gnomAD
CA9352913 rs769319004	377	H>Q		No	ClinGen ExAC gnomAD
CA306824765 rs149845017	378	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs149845017 CA9352914	378	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs762620133 CA9352915	379	A>V		No	ClinGen ExAC gnomAD
CA9352916 rs763829751	380	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs202176858 CA9352917	382	L>V		No	ClinGen ExAC TOPMed gnomAD
CA9352919 rs367598872	383	P>L		No	ClinGen ExAC TOPMed gnomAD
CA405149343 rs367598872	383	P>R		No	ClinGen ExAC TOPMed gnomAD
rs755058946 CA9352921	384	T>S		No	ClinGen ExAC TOPMed gnomAD
CA9352922 rs778999345	386	R>G		No	ClinGen ExAC gnomAD
CA9352923 rs778999345	386	R>W		No	ClinGen ExAC gnomAD
CA405149362 rs1158251941	387	T>A		No	ClinGen gnomAD
CA9352924 rs758579896	387	T>K		No	ClinGen ExAC TOPMed gnomAD
CA405149365 rs758579896	387	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1338779708 CA405149374	389	A>S		No	ClinGen TOPMed
CA306824819 rs1012029652	392	Y>C		No	ClinGen Ensembl
CA405149432 rs1330312899	396	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs779447454 CA9352952	398	V>A		No	ClinGen ExAC gnomAD
rs1326119031 CA405149453	399	V>L		No	ClinGen TOPMed
TCGA novel	404	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768120343 CA9352954	406	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs140683632 CA9352955	406	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs199895593 CA306825445	408	S>F		No	ClinGen 1000Genomes
TCGA novel	410	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs202122748 CA9352956	414	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771884253 CA9352957	414	S>N		No	ClinGen ExAC gnomAD
rs201902251 CA9352959	417	N>S		No	ClinGen ExAC TOPMed gnomAD
CA9352960 rs760542711	418	S>N		No	ClinGen ExAC gnomAD
rs766397820 CA405149581	418	S>R		No	ClinGen ExAC gnomAD
rs1322444534 CA405149583	419	V>M		No	ClinGen gnomAD
rs371849144 CA9352963	421	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9352964 rs764248291	422	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs751855285 CA9352965	423	T>A		No	ClinGen ExAC gnomAD
rs200140311 CA9352966	424	S>N		No	ClinGen ExAC TOPMed gnomAD
CA9352969 rs756425384	425	E>G		No	ClinGen ExAC gnomAD
CA9352968 rs750745898	425	E>K		No	ClinGen ExAC TOPMed gnomAD
CA405149637 rs1289428133	427	S>G		No	ClinGen gnomAD
rs962636548 CA306825536	428	A>G		No	ClinGen TOPMed
CA9352970 rs780647923	428	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	430	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749733546 CA9352971	433	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA306825538 rs1043876	434	R>G		No	ClinGen Ensembl
rs778352287 CA9352973	435	R>Q	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9352972 rs754502991	435	R>W		No	ClinGen ExAC gnomAD
rs1374344156 CA405149694	436	G>R		No	ClinGen gnomAD
rs1599729263 CA405149705	437	V>G		No	ClinGen Ensembl
CA405149707 rs747802047	438	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1162351179 CA405149716	439	R>K		No	ClinGen TOPMed gnomAD
CA405149715 rs1162351179	439	R>M		No	ClinGen TOPMed gnomAD
rs1599729281 CA405149727	440	S>R		No	ClinGen Ensembl
rs1388134826 CA405149730	441	I>F		No	ClinGen TOPMed gnomAD
CA405149729 rs1388134826	441	I>V		No	ClinGen TOPMed gnomAD
rs772726084 CA9352976	444	E>K		No	ClinGen ExAC TOPMed gnomAD
CA405149751 rs772726084	444	E>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	445	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	445	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9352978 rs770601535	447	T>A		No	ClinGen ExAC gnomAD
rs776680830 CA405149784	448	C>W		No	ClinGen ExAC TOPMed gnomAD
CA306825585 rs960201188	449	S>G		No	ClinGen TOPMed
CA405149807 rs1426992325	452	S>G		No	ClinGen TOPMed
CA405149824 rs1453684819	454	S>G		No	ClinGen TOPMed
TCGA novel	454	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs916010752 CA306825595	456	L>V		No	ClinGen TOPMed
rs764303297 CA9352981	457	E>K		No	ClinGen ExAC gnomAD
CA9352982 rs200935752	459	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1293008742 CA405149875	461	Q>R		No	ClinGen gnomAD
CA405149882 rs1264469709	462	E>A		No	ClinGen gnomAD
rs1215155418 CA405149880	462	E>Q		No	ClinGen gnomAD
rs1215320983 CA405149937	469	P>L		No	ClinGen TOPMed
rs750610418 CA9352985	470	L>S		No	ClinGen ExAC gnomAD
rs1366149091 CA405149948	471	S>L		No	ClinGen gnomAD
CA306825639 rs956815854	471	S>P		No	ClinGen TOPMed gnomAD
rs761163095 CA9352986	472	V>I		No	ClinGen ExAC gnomAD
CA405149958 rs1568449171	473	T>I		No	ClinGen Ensembl
CA405149964 rs1370841788	474	P>L		No	ClinGen TOPMed
CA9352987 rs764548214	474	P>T		No	ClinGen ExAC TOPMed gnomAD
rs986967061 CA306826775	476	A>T		No	ClinGen TOPMed
CA9353019 rs759872904	478	S>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	478	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405150173 rs1489352401	481	V>L		No	ClinGen Ensembl
CA9353022 rs753197749	482	I>M		No	ClinGen ExAC TOPMed gnomAD
CA9353021 rs373253999	482	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1568450542 CA405150185	482	I>V		No	ClinGen Ensembl
CA405150206 rs1456066999	483	E>G		No	ClinGen TOPMed
TCGA novel	485	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9353023 rs546240679	487	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1194138839 CA405150279	488	S>L		No	ClinGen gnomAD
CA306826800 rs919984169	490	S>F		No	ClinGen TOPMed
CA9353026 rs756817121	491	L>*		No	ClinGen ExAC
rs1233237269 CA405150305	491	L>V		No	ClinGen gnomAD
rs376131445 CA9353027	492	T>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA405150332 rs1309045827	493	P>S		No	ClinGen TOPMed
rs749183650 CA9353031	494	P>L		No	ClinGen ExAC gnomAD
CA405150345 rs1256816514	494	P>S		No	ClinGen gnomAD
rs1256816514 CA405150344	494	P>T		No	ClinGen gnomAD
CA405150354 rs77842821	495	P>A		No	ClinGen ExAC TOPMed gnomAD
rs773128187 CA9353033	495	P>L		No	ClinGen ExAC gnomAD
CA9353032 rs77842821	495	P>S		No	ClinGen ExAC TOPMed gnomAD
rs77842821 CA405150352	495	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1432372950 CA405150367	496	A>S		No	ClinGen gnomAD
CA9353037 rs140860233	499	H>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1393179040 CA405150430	500	P>L		No	ClinGen TOPMed
rs199962604 CA9353039	501	A>S		No	ClinGen ExAC TOPMed gnomAD
CA9353038 rs199962604	501	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs775988779 CA9353041	506	P>A		No	ClinGen ExAC TOPMed gnomAD
rs775988779 CA405150498	506	P>S		No	ClinGen ExAC TOPMed gnomAD
CA306826843 rs143034255	508	R>*		No	ClinGen ESP TOPMed gnomAD
rs763301059 CA9353042	508	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	509	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763688609 CA9353043	509	K>T		No	ClinGen ExAC gnomAD
CA9353045 rs756765111	512	L>P		No	ClinGen ExAC gnomAD
CA405150615 rs750090894	515	A>P		No	ClinGen ExAC gnomAD
rs750090894 CA9353047	515	A>T		No	ClinGen ExAC gnomAD
CA405150636 rs1207853022	516	S>C		No	ClinGen TOPMed gnomAD
CA405150628 rs1486062255	516	S>P		No	ClinGen TOPMed
rs1207853022 CA405150633	516	S>Y		No	ClinGen TOPMed gnomAD
rs749271708 CA9353050	518	E>D		No	ClinGen ExAC TOPMed gnomAD
rs779931177 CA9353049	518	E>G		No	ClinGen ExAC TOPMed gnomAD
rs990036209 CA306826855	519	T>A		No	ClinGen Ensembl
rs778888795 CA9353052	520	G>V		No	ClinGen ExAC gnomAD
CA405150709 rs1426813016	522	R>K		No	ClinGen gnomAD
CA405150722 rs1167908717	523	V>I		No	ClinGen TOPMed gnomAD
CA9353055 rs771039160	525	K>N		No	ClinGen ExAC gnomAD
rs1367816271 CA405150797	528	A>D		No	ClinGen gnomAD
rs746031732 CA9353056	528	A>P		No	ClinGen ExAC gnomAD
TCGA novel	529	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1406147554 CA405150812	529	A>V		No	ClinGen gnomAD
CA9353059 rs185999361	531	L>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs185999361 CA9353058	531	L>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9353060 rs764555561	532	Q>H		No	ClinGen ExAC gnomAD
rs774887145 CA9353061	533	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA405150873 rs1293717299	534	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1490445060 CA405150885	535	D>N		No	ClinGen gnomAD

No associated diseases with O94763

No regional properties for O94763

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O94763

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm Mitochondrion Cell projection, dendrite	Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
chaperone complex	A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RPAP3/R2TP/prefoldin-like complex	A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity.

6 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
phosphatase inhibitor activity	Binds to and stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.
phosphoprotein binding	Binding to a phosphorylated protein.
protein phosphatase inhibitor activity	Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins.
RNA polymerase II complex binding	Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

9 GO annotations of biological process

Name	Definition
cellular response to growth factor stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
cellular response to steroid hormone stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
negative regulation of intrinsic apoptotic signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
negative regulation of phosphatase activity	Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to virus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3B7M7	URI1	Unconventional prefoldin RPB5 interactor	Bos taurus (Bovine)	PR
Q3TLD5	Uri1	Unconventional prefoldin RPB5 interactor	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEAPTVETPP	DPSPPSAPAP	ALVPLRAPDV	ARLREEQEKV	VTNCQERIQH	WKKVDNDYNA
70	80	90	100	110	120
LRERLSTLPD	KLSYNIMVPF	GPFAFMPGKL	VHTNEVTVLL	GDNWFAKCSA	KQAVGLVEHR
130	140	150	160	170	180
KEHVRKTIDD	LKKVMKNFES	RVEFTEDLQK	MSDAAGDIVD	IREEIKCDFE	FKAKHRIAHK
190	200	210	220	230	240
PHSKPKTSDI	FEADIANDVK	SKDLLADKEL	WARLEELERQ	EELLGELDSK	PDTVIANGED
250	260	270	280	290	300
TTSSEEEKED	RNTNVNAMHQ	VTDSHTPCHK	DVASSEPFSG	QVNSQLNCSV	NGSSSYHSDD
310	320	330	340	350	360
DDDDDDDDDD	DNIDDDDGDN	DHEALGVGDN	SIPTIYFSHT	VEPKRVRINT	GKNTTLKFSE
370	380	390	400	410	420
KKEEAKRKRK	NSTGSGHSAQ	ELPTIRTPAD	IYRAFVDVVN	GEYVPRKSIL	KSRSRENSVC
430	440	450	460	470	480
SDTSESSAAE	FDDRRGVLRS	ISCEEATCSD	TSESILEEEP	QENQKKLLPL	SVTPEAFSGT
490	500	510	520	530
VIEKEFVSPS	LTPPPAIAHP	ALPTIPERKE	VLLEASEETG	KRVSKFKAAR	LQQKD