Q3T022

PR
Gene name
SAP18
Protein name
Histone deacetylase complex subunit SAP18
Names
18 kDa Sin3-associated polypeptide, Sin3-associated polypeptide p18
Species
Bos taurus (Bovine)
KEGG Pathway
bta:615692
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3T022

Entry ID Method Resolution Chain Position Source
AF-Q3T022-F1 Predicted AlphaFoldDB

No variants for Q3T022

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3T022

No associated diseases with Q3T022

No regional properties for Q3T022

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3T022

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Nucleus speckle
  • Shuttles between the nucleus and the cytoplasm (By similarity)
  • Colocalizes with ACIN1 and SRSF2 in nuclear speckles (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
ASAP complex A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

6 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of mRNA splicing, via spliceosome Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
regulation of alternative mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O00422 SAP18 Histone deacetylase complex subunit SAP18 Homo sapiens (Human) PR
O55128 Sap18 Histone deacetylase complex subunit SAP18 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT
70 80 90 100 110 120
WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDLKRPG YRVKEIGSTM SGRKGTDDSM
130 140 150
TLQSQKFQIG DYLDIAITPP NRAPPTSGRM RPY