O55128

PR
Gene name
Sap18
Protein name
Histone deacetylase complex subunit SAP18
Names
18 kDa Sin3-associated polypeptide, Sin3-associated polypeptide p18
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20220
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for O55128

Entry ID Method Resolution Chain Position Source
4A6Q X-ray 150 A A 6-143 PDB
4A8X X-ray 190 A C 14-143 PDB
4A90 X-ray 190 A A/B 1-143 PDB
AF-O55128-F1 Predicted AlphaFoldDB

No variants for O55128

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O55128

No associated diseases with O55128

No regional properties for O55128

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O55128

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Nucleus speckle
  • Shuttles between the nucleus and the cytoplasm (By similarity)
  • Colocalizes with ACIN1 and SRSF2 in nuclear speckles (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
ASAP complex A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
exon-exon junction complex A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.
histone deacetylase complex A protein complex that possesses histone deacetylase activity.
nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

1 GO annotations of molecular function

Name Definition
transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

7 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of mRNA splicing, via spliceosome Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
regulation of alternative mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T022 SAP18 Histone deacetylase complex subunit SAP18 Bos taurus (Bovine) PR
O00422 SAP18 Histone deacetylase complex subunit SAP18 Homo sapiens (Human) PR
10 20 30 40 50 60
MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT
70 80 90 100 110 120
WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFMDLKRPG YRVKEIGSTM SGRKGTDDSM
130 140 150
TLQSQKFQIG DYLDIAITPP NRAPPSSGRM RPY