Q3SZH6

PR
Gene name
TTLL9
Protein name
Probable tubulin polyglutamylase TTLL9
Names
Tubulin--tyrosine ligase-like protein 9
Species
Bos taurus (Bovine)
KEGG Pathway
bta:529246
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SZH6

Entry ID Method Resolution Chain Position Source
AF-Q3SZH6-F1 Predicted AlphaFoldDB

94 variants for Q3SZH6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs444454459 5 K>Q No EVA
rs380759559 15 Q>P No EVA
rs386040656 19 E>D No EVA
rs1117193680 20 R>Q No EVA
rs1116365489 27 R>L No EVA
rs465309578 103 R>L No EVA
rs385245159 130 E>K No EVA
rs432418734 135 V>A No EVA
rs434107935 157 K>E No EVA
rs455665577 161 L>I No EVA
rs434523053 174 G>A No EVA
rs452928153 175 T>A No EVA
rs452928153 175 T>P No EVA
rs474464451 176 A>G No EVA
rs443869708 179 K>N No EVA
rs459176524 180 L>P No EVA
rs477643422 181 T>P No EVA
rs441346896 182 S>G No EVA
rs459838702 182 S>T No EVA
rs448507570 183 L>R No EVA
rs481471991 183 L>V No EVA
rs470156282 184 E>G No EVA
rs482889296 185 A>P No EVA
rs445885352 190 N>T No EVA
rs477984515 225 Y>C No EVA
rs521493493 263 F>L No EVA
rs519389800 263 F>Y No EVA
rs460626607 273 V>F No EVA
rs460626607 273 V>L No EVA
rs472777800 277 N>I No EVA
rs461421822 278 V>G No EVA
rs450132994 280 V>A No EVA
rs477342355 282 K>* No EVA
rs447581780 282 K>R No EVA
rs466021269 283 T>P No EVA
rs469888548 286 D>A No EVA
rs469888548 286 D>G No EVA
rs436868119 287 Y>* No EVA
rs452026924 288 H>L No EVA
rs452026924 288 H>P No EVA
rs470404573 288 H>Q No EVA
rs446358771 293 C>R No EVA
rs464815370 293 C>W No EVA
rs434989820 295 W>G No EVA
rs434989820 295 W>R No EVA
rs468726432 312 A>E No EVA
rs468726432 312 A>G No EVA
rs435664801 314 E>K No EVA
rs457210636 318 S>R No EVA
rs475603047 324 F>Y No EVA
rs876175150 325 I>L No EVA
rs433098190 331 V>A No EVA
rs451506350 332 Q>L No EVA
rs473253616 333 K>T No EVA
rs455431008 340 H>L No EVA
rs440213927 340 H>N No EVA
rs473960606 342 F>V No EVA
rs444084303 344 L>R No EVA
rs462594839 346 G>C No EVA
rs477802050 348 D>A No EVA
rs438381156 349 I>M No EVA
rs453494838 350 L>V No EVA
rs480149610 351 I>L No EVA
rs447073210 351 I>R No EVA
rs468737723 352 D>A No EVA
rs480795363 353 Q>E No EVA
rs480795363 353 Q>K No EVA
rs450899645 353 Q>R No EVA
rs469266681 354 D>A No EVA
rs433163925 355 L>P No EVA
rs466918561 356 K>* No EVA
rs476672663 358 W>G No EVA
rs476672663 358 W>R No EVA
rs443671593 361 E>A No EVA
rs458917311 363 N>K No EVA
rs477388042 367 S>* No EVA
rs441089585 370 A>T No EVA
rs481274788 375 D>N No EVA
rs448161031 377 E>Q No EVA
rs481705548 386 T>P No EVA
rs464157549 390 V>A No EVA
rs464157549 390 V>G No EVA
rs434328927 391 D>E No EVA
rs432585800 438 C>R No EVA
rs454228401 438 C>S No EVA
rs472725230 438 C>W No EVA
rs436475551 439 V>G No EVA
rs1117480247 439 V>I No EVA
rs454981016 443 K>T No EVA
rs476612954 444 E>K No EVA
rs443563709 445 Q>E No EVA
rs446036741 445 Q>P No EVA
rs458872560 448 Q>K No EVA
rs470852079 457 K>R No EVA

No associated diseases with Q3SZH6

No regional properties for Q3SZH6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3SZH6

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton, cilium basal body
  • Cytoplasm, cytoskeleton
  • Cytoplasm, cytoskeleton, flagellum axoneme
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
tubulin binding Binding to monomeric or multimeric forms of tubulin, including microtubules.
tubulin-glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.

3 GO annotations of biological process

Name Definition
flagellated sperm motility The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
protein polyglutamylation The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BWV7 TTLL2 Probable tubulin polyglutamylase TTLL2 Homo sapiens (Human) PR
Q3SXZ7 TTLL9 Probable tubulin polyglutamylase TTLL9 Homo sapiens (Human) PR
A2APC3 Ttll9 Probable tubulin polyglutamylase TTLL9 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSRPKNQNYK GHGLQKGKER EQRASIRFKT TLMNTLMDVL RHRPGWVEVK DEGEWDFYWC
70 80 90 100 110 120
DVSWLRENFD HTYMGEHVRI SHFRNHYELT RKNYMVKNLK RFRKQLEREA GKLEAAKCDF
130 140 150 160 170 180
FPKTFEMPCE YHLFVEEFRK NPGITWIMKP VARSQGKGIF LFRRLKDIMD WKKGTAGKKL
190 200 210 220 230 240
TSLEAQPARN TVNPSGSHDT RSSDDQKDEI PVENYVAQRY IENPYLIGGR KFDLRVYVLV
250 260 270 280 290 300
MSYIPLRAWL YRDGFARFSN TRFTLNSIDD QYVHLTNVAV QKTSPDYHPK KGCKWMLQRF
310 320 330 340 350 360
RQYLASKHGP EAVETLFSDM DNIFIRSLQS VQKVIISDKH CFELYGYDIL IDQDLKPWLL
370 380 390 400 410 420
EVNASPSLTA SSQEDYELKT CLLEDTLHIV DMEARLTGRE KRVGGFDLMW NDGPVSREEG
430 440 450 460
GPDLSGMGNF VTNTHLGCVN DRKEQLRQLF RSLQGQKKTP N