Q3SZA5
Gene name |
SMS |
Protein name |
Spermine synthase |
Names |
SPMSY, Spermidine aminopropyltransferase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:615950 |
EC number |
2.5.1.22: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3SZA5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3SZA5-F1 | Predicted | AlphaFoldDB |
25 variants for Q3SZA5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs481041084 | 89 | L>F | No | EVA | |
| rs475377106 | 119 | I>T | No | EVA | |
| rs456921732 | 120 | D>E | No | EVA | |
| rs450880552 | 170 | A>G | No | EVA | |
| rs468869031 | 172 | S>I | No | EVA | |
| rs479996721 | 181 | M>L | No | EVA | |
| rs458367332 | 198 | G>V | No | EVA | |
| rs439236433 | 200 | D>A | No | EVA | |
| rs481976408 | 207 | I>T | No | EVA | |
| rs463458767 | 211 | K>T | No | EVA | |
| rs441564161 | 214 | M>I | No | EVA | |
| rs474435980 | 219 | E>G | No | EVA | |
| rs468522832 | 288 | D>A | No | EVA | |
| rs453338495 | 291 | W>* | No | EVA | |
| rs434816488 | 291 | W>C | No | EVA | |
| rs464858846 | 295 | R>S | No | EVA | |
| rs446336178 | 297 | I>V | No | EVA | |
| rs437375032 | 302 | M>L | No | EVA | |
| rs470224214 | 303 | K>* | No | EVA | |
| rs448062826 | 304 | V>A | No | EVA | |
| rs448062826 | 304 | V>G | No | EVA | |
| rs449941981 | 335 | Y>S | No | EVA | |
| rs482923074 | 337 | P>T | No | EVA | |
| rs461284312 | 344 | I>L | No | EVA | |
| rs464921753 | 364 | K>N | No | EVA |
No associated diseases with Q3SZA5
4 regional properties for Q3SZA5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Polyamine biosynthesis domain, conserved site | 193 - 206 | IPR030373 |
| domain | Polyamine biosynthesis domain | 121 - 361 | IPR030374 |
| domain | Spermidine synthase, tetramerisation domain | 122 - 171 | IPR035246 |
| domain | Spermine synthase, N-terminal | 21 - 116 | IPR040900 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.22 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| spermine synthase activity | Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| spermine biosynthetic process | The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAARHSTLD | FMLGAKADGE | TILKGLQSIF | QEQGMTESVH | TWQDHGYLAT | YINKNGSFAN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LRIYPHGLVL | LDLQSYDGDA | QGKEVDSLLN | KVEERMKELS | QDSTERVKRL | PPIVRGGAID |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RYWPTADGRL | VEYDIDKVVY | DEDSPYQNIK | ILHSKQFGNI | LILSGDVNLA | ESDLAYTRAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MGSGKEDYSG | KDVLILGGGD | GGILCEIVKL | KPKMVTMVEI | DQMVIDGCKK | YMRKTCGDVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DNLKGDCYQV | LIEDCIPVLK | RYAKEGREFD | YVINDLTAVP | ISTSPEEDST | WEFLRLILDL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SMKVLKQDGK | YFTQGNCVNL | TEALSLYEEQ | LGRLYCPVEF | SKEIVCVPSY | LELWVFYTVW |
| KKAKP |