P97355

PR
Gene name
Sms
Protein name
Spermine synthase
Names
SPMSY, Spermidine aminopropyltransferase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:20603
EC number
2.5.1.22: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-134 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P97355

Entry ID Method Resolution Chain Position Source
AF-P97355-F1 Predicted AlphaFoldDB

22 variants for P97355

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389589488 17 A>D No EVA
rs3412027959 33 Q>* No EVA
rs3412557290 33 Q>R No EVA
rs3412027949 49 A>S No EVA
rs3412351479 56 G>A No EVA
rs3389539091 61 L>* No EVA
rs1132416761 69 V>M No EVA
rs1134542460 70 L>F No EVA
rs3389581768 75 S>T No EVA
rs3412385197 106 G>R No EVA
rs3389584477 138 E>D No EVA
rs3389577405 142 D>V No EVA
rs3389581752 182 M>L No EVA
rs3412468223 215 M>I No EVA
rs3411639909 216 V>I No EVA
rs3412556431 217 T>S No EVA
rs3389489179 257 I>T No EVA
rs3389577430 267 G>W No EVA
rs3389581747 268 R>S No EVA
rs3412352581 285 S>A No EVA
rs3389539065 315 Q>H No EVA
rs3389539088 334 R>C No EVA

No associated diseases with P97355

4 regional properties for P97355

Type Name Position InterPro Accession
conserved_site Polyamine biosynthesis domain, conserved site 194 - 207 IPR030373
domain Polyamine biosynthesis domain 122 - 362 IPR030374
domain Spermidine synthase, tetramerisation domain 123 - 172 IPR035246
domain Spermine synthase, N-terminal 21 - 117 IPR040900

Functions

Description
EC Number 2.5.1.22 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
spermine synthase activity Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.

2 GO annotations of biological process

Name Definition
spermine biosynthetic process The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.
spermine metabolic process The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZA5 SMS Spermine synthase Bos taurus (Bovine) PR
P52788 SMS Spermine synthase Homo sapiens (Human) PR
10 20 30 40 50 60
MAAARHSTLD FKLGAKADGE AILKGLQSIF QEQGMTESVH TWQDHGYLAT YTNKNGSFAN
70 80 90 100 110 120
LRIYPHGLVL LDLQSYDSDV QGKQETDSLL NKIEEKMKEL SQDSTGRVKR LPPIVRGGAI
130 140 150 160 170 180
DRYWPTADGR LVEYDIDEVV YDEDSPYQNI KILHSKQFGN ILILSGDVNL AESDLAYTRA
190 200 210 220 230 240
IMGSGKEDYT GKDVLILGGG DGGILCEIVK LKPKMVTMVE IDQMVIDGCK KYMRRTCGDV
250 260 270 280 290 300
LDNLRGDCYQ VLIEDCIPVL KMYAKEGREF DYVINDLTAV PISTSPEEDS TWDFLRLILD
310 320 330 340 350 360
LSMKVLKQDG KYFTQGNCVN LTEALSLYEE QLGRLYCPVE FSKEIVCVPS YLELWVFYTV
WKKAKP