Q3MHR2
PR
Gene name |
DCK |
Protein name |
Deoxycytidine kinase |
Names |
dCK, Deoxyadenosine kinase, Deoxyguanosine kinase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:530642 |
EC number |
2.7.1.74: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3MHR2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3MHR2-F1 | Predicted | AlphaFoldDB |
102 variants for Q3MHR2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs479077247 | 7 | R>W | No | EVA | |
| rs457716991 | 8 | S>R | No | EVA | |
| rs439197141 | 8 | S>R | No | EVA | |
| rs482833861 | 17 | E>G | No | EVA | |
| rs449754041 | 19 | T>P | No | EVA | |
| rs454905435 | 72 | T>P | No | EVA | |
| rs473519995 | 73 | T>S | No | EVA | |
| rs452481587 | 75 | Q>E | No | EVA | |
| rs471211086 | 77 | S>R | No | EVA | |
| rs444566767 | 78 | G>C | No | EVA | |
| rs134192854 | 80 | N>D | No | EVA | |
| rs459973977 | 80 | N>K | No | EVA | |
| rs441596809 | 80 | N>S | No | EVA | |
| rs445732242 | 81 | V>D | No | EVA | |
| rs478787872 | 81 | V>F | No | EVA | |
| rs445732242 | 81 | V>G | No | EVA | |
| rs457718254 | 82 | L>F | No | EVA | |
| rs457718254 | 82 | L>I | No | EVA | |
| rs457718254 | 82 | L>V | No | EVA | |
| rs449867298 | 83 | Q>H | No | EVA | |
| rs482890680 | 83 | Q>L | No | EVA | |
| rs482890680 | 83 | Q>P | No | EVA | |
| rs482890680 | 83 | Q>R | No | EVA | |
| rs448541126 | 84 | M>I | No | EVA | |
| rs435455348 | 84 | M>K | No | EVA | |
| rs468502648 | 84 | M>L | No | EVA | |
| rs468502648 | 84 | M>V | No | EVA | |
| rs452602956 | 85 | M>I | No | EVA | |
| rs433928152 | 85 | M>K | No | EVA | |
| rs467002064 | 85 | M>L | No | EVA | |
| rs433928152 | 85 | M>T | No | EVA | |
| rs467002064 | 85 | M>V | No | EVA | |
| rs456551989 | 86 | Y>* | No | EVA | |
| rs438194480 | 86 | Y>C | No | EVA | |
| rs471040879 | 86 | Y>D | No | EVA | |
| rs438194480 | 86 | Y>F | No | EVA | |
| rs475155123 | 87 | E>* | No | EVA | |
| rs460639004 | 87 | E>D | No | EVA | |
| rs442266576 | 87 | E>G | No | EVA | |
| rs475155123 | 87 | E>K | No | EVA | |
| rs442266576 | 87 | E>V | No | EVA | |
| rs472232903 | 88 | K>E | No | EVA | |
| rs439156664 | 88 | K>I | No | EVA | |
| rs457855684 | 88 | K>N | No | EVA | |
| rs472232903 | 88 | K>Q | No | EVA | |
| rs482768781 | 89 | P>A | No | EVA | |
| rs449930819 | 89 | P>H | No | EVA | |
| rs482768781 | 89 | P>T | No | EVA | |
| rs480374931 | 90 | E>* | No | EVA | |
| rs480374931 | 90 | E>K | No | EVA | |
| rs480374931 | 90 | E>Q | No | EVA | |
| rs447588112 | 90 | E>V | No | EVA | |
| rs433990436 | 91 | R>P | No | EVA | |
| rs464694937 | 92 | W>G | No | EVA | |
| rs438055538 | 92 | W>L | No | EVA | |
| rs464694937 | 92 | W>R | No | EVA | |
| rs456615445 | 93 | S>A | No | EVA | |
| rs468612660 | 93 | S>C | No | EVA | |
| rs468612660 | 93 | S>F | No | EVA | |
| rs468612660 | 93 | S>Y | No | EVA | |
| rs454432304 | 94 | F>Y | No | EVA | |
| rs439218983 | 95 | T>I | No | EVA | |
| rs439218983 | 95 | T>N | No | EVA | |
| rs472841071 | 95 | T>P | No | EVA | |
| rs472841071 | 95 | T>S | No | EVA | |
| rs480436703 | 97 | Q>H | No | EVA | |
| rs443332972 | 97 | Q>K | No | EVA | |
| rs461794961 | 97 | Q>L | No | EVA | |
| rs461794961 | 97 | Q>P | No | EVA | |
| rs441011025 | 98 | S>T | No | EVA | |
| rs446074123 | 100 | A>G | No | EVA | |
| rs478133662 | 100 | A>S | No | EVA | |
| rs482785739 | 101 | C>F | No | EVA | |
| rs464515737 | 101 | C>R | No | EVA | |
| rs482785739 | 101 | C>S | No | EVA | |
| rs450097045 | 102 | L>P | No | EVA | |
| rs435767295 | 103 | S>R | No | EVA | |
| rs454228143 | 103 | S>T | No | EVA | |
| rs466510289 | 106 | R>Q | No | EVA | |
| rs451321314 | 108 | Q>H | No | EVA | |
| rs455446066 | 123 | V>A | No | EVA | |
| rs441019996 | 124 | L>* | No | EVA | |
| rs459475959 | 126 | F>Y | No | EVA | |
| rs478189650 | 131 | Y>H | No | EVA | |
| rs438698296 | 132 | S>R | No | EVA | |
| rs463617157 | 133 | D>E | No | EVA | |
| rs443069155 | 137 | F>L | No | EVA | |
| rs443069155 | 137 | F>V | No | EVA | |
| rs473742383 | 146 | C>S | No | EVA | |
| rs459133766 | 152 | W>C | No | EVA | |
| rs476826917 | 154 | I>M | No | EVA | |
| rs450382754 | 161 | W>L | No | EVA | |
| rs448226422 | 173 | D>E | No | EVA | |
| rs445949829 | 176 | I>F | No | EVA | |
| rs464424856 | 176 | I>M | No | EVA | |
| rs432378526 | 179 | R>G | No | EVA | |
| rs479067927 | 223 | T>S | No | EVA | |
| rs450233975 | 247 | D>N | No | EVA | |
| rs464085145 | 258 | S>G | No | EVA | |
| rs482569996 | 260 | L>W | No | EVA | |
| rs467403260 | 261 | L>C | No | EVA | |
| rs448826930 | 261 | L>S | No | EVA |
No associated diseases with Q3MHR2
1 regional properties for Q3MHR2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Deoxynucleoside kinase domain | 23 - 257 | IPR031314 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.74 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cytidine kinase activity | Catalysis of the reaction: ATP + cytidine = ADP + CMP. |
| deoxyadenosine kinase activity | Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+). |
| deoxycytidine kinase activity | Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. |
| deoxyguanosine kinase activity | Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+). |
| deoxynucleoside kinase activity | Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| dAMP salvage | Any process which produces a dAMP from derivatives of it, without de novo synthesis. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| pyrimidine nucleotide metabolic process | The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATPPKRSCP | SPAASSEGTR | IKKISIEGNI | AAGKSTFVNI | LKQVCEDWEV | VPEPVARWCN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VQSTQDEFEE | LTTSQKSGGN | VLQMMYEKPE | RWSFTFQSYA | CLSRIRAQLA | ALNGKLKDAE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPVLFFERSV | YSDRYIFASN | LYESDCMNET | EWTIYQDWHD | WMNNQFGQSL | ELDGIIYLRA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TPEKCLNRIY | LRGRNEEQGI | PLEYLEKLHY | KHESWLLHRT | LKTNFDYLQE | VPILTLDVNE |
| 250 | |||||
| DFKDKHDSLI | EKVKDFLSTL |