P43346

PR
Gene name
Dck
Protein name
Deoxycytidine kinase
Names
dCK, Deoxyadenosine kinase, Deoxyguanosine kinase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:13178
EC number
2.7.1.74: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P43346

Entry ID Method Resolution Chain Position Source
AF-P43346-F1 Predicted AlphaFoldDB

3 variants for P43346

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3395835854 29 N>I No EVA
rs3395487401 141 L>* No EVA
rs3388739747 201 P>H No EVA

No associated diseases with P43346

1 regional properties for P43346

Type Name Position InterPro Accession
domain Deoxynucleoside kinase domain 23 - 257 IPR031314

Functions

Description
EC Number 2.7.1.74 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

10 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cytidine kinase activity Catalysis of the reaction: ATP + cytidine = ADP + CMP.
deoxyadenosine kinase activity Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+).
deoxycytidine kinase activity Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.
deoxyguanosine kinase activity Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+).
deoxynucleoside kinase activity Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate.
deoxyribonucleoside binding Binding to a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose.
magnesium ion binding Binding to a magnesium (Mg) ion.
protein homodimerization activity Binding to an identical protein to form a homodimer.
pyrimidine deoxyribonucleoside binding Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose.

6 GO annotations of biological process

Name Definition
dAMP salvage Any process which produces a dAMP from derivatives of it, without de novo synthesis.
deoxycytidine metabolic process The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA.
dGMP salvage Any process which produces a dGMP from derivatives of it, without de novo synthesis.
nucleoside phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleoside phosphate.
nucleotide phosphorylation The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside.
pyrimidine nucleotide metabolic process The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHR2 DCK Deoxycytidine kinase Bos taurus (Bovine) PR
O00142 TK2 Thymidine kinase 2, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MATPPKRFCP SPSTSSEGTR IKKISIEGNI AAGKSTFVNI LKQASEDWEV VPEPVARWCN
70 80 90 100 110 120
VQSTQEEFEE LTTSQKSGGN VLQMMYEKPE RWSFTFQSYA CLSRIRAQLA SLNGKLKDAE
130 140 150 160 170 180
KPVLFFERSV YSDRYIFASN LYESDCMNET EWTIYQDWHD WMNSQFGQSL ELDGIIYLRA
190 200 210 220 230 240
TPEKCLNRIY LRGRNEEQGI PLEYLEKLHY KHESWLLHRT LKTSFDYLQE VPVLTLDVNE
250
DFKDKHESLV EKVKEFLSTL