Q3MHH2
PR
Gene name |
NOL11 |
Protein name |
Nucleolar protein 11 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:517743 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3MHH2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3MHH2-F1 | Predicted | AlphaFoldDB |
123 variants for Q3MHH2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs472468226 | 9 | A>E | No | EVA | |
| rs384759850 | 11 | T>N | No | EVA | |
| rs467729121 | 18 | G>R | No | EVA | |
| rs382769376 | 29 | G>D | No | EVA | |
| rs437466222 | 43 | V>G | No | EVA | |
| rs469138585 | 76 | G>S | No | EVA | |
| rs483076763 | 77 | E>* | No | EVA | |
| rs458235967 | 77 | E>A | No | EVA | |
| rs465134402 | 106 | S>A | No | EVA | |
| rs446627370 | 109 | V>G | No | EVA | |
| rs466913890 | 117 | G>R | No | EVA | |
| rs481218160 | 124 | F>Y | No | EVA | |
| rs451086496 | 128 | A>S | No | EVA | |
| rs478499978 | 137 | A>T | No | EVA | |
| rs459119267 | 150 | E>K | No | EVA | |
| rs459832650 | 155 | W>G | No | EVA | |
| rs441370326 | 158 | F>I | No | EVA | |
| rs474179295 | 161 | V>E | No | EVA | |
| rs455744550 | 168 | I>N | No | EVA | |
| rs439852996 | 174 | H>P | No | EVA | |
| rs472707335 | 174 | H>Q | No | EVA | |
| rs454135800 | 175 | G>E | No | EVA | |
| rs475055031 | 176 | N>K | No | EVA | |
| rs464129086 | 177 | Y>* | No | EVA | |
| rs437719331 | 177 | Y>F | No | EVA | |
| rs456190640 | 177 | Y>H | No | EVA | |
| rs452033415 | 179 | V>F | No | EVA | |
| rs433817322 | 180 | Y>F | No | EVA | |
| rs448434089 | 181 | V>A | No | EVA | |
| rs466880670 | 181 | V>L | No | EVA | |
| rs481212471 | 182 | Q>K | No | EVA | |
| rs450130238 | 188 | I>F | No | EVA | |
| rs483205090 | 190 | S>R | No | EVA | |
| rs458093054 | 212 | G>A | No | EVA | |
| rs454543010 | 229 | E>G | No | EVA | |
| rs436226522 | 249 | Q>H | No | EVA | |
| rs457271511 | 250 | L>S | No | EVA | |
| rs432168629 | 251 | L>I | No | EVA | |
| rs465195964 | 252 | K>* | No | EVA | |
| rs434066191 | 277 | G>E | No | EVA | |
| rs449930142 | 286 | C>* | No | EVA | |
| rs457879964 | 289 | V>L | No | EVA | |
| rs438893919 | 290 | W>* | No | EVA | |
| rs478304048 | 292 | T>R | No | EVA | |
| rs441234358 | 299 | T>A | No | EVA | |
| rs474256470 | 303 | L>F | No | EVA | |
| rs443929177 | 305 | Q>H | No | EVA | |
| rs476807290 | 308 | S>R | No | EVA | |
| rs451833530 | 310 | Q>H | No | EVA | |
| rs459482610 | 352 | G>C | No | EVA | |
| rs459482610 | 352 | G>S | No | EVA | |
| rs471457558 | 359 | F>C | No | EVA | |
| rs452479247 | 361 | N>S | No | EVA | |
| rs434060099 | 380 | R>* | No | EVA | |
| rs517713268 | 393 | P>S | No | EVA | |
| rs134045444 | 399 | T>R | No | EVA | |
| rs459691584 | 401 | L>H | No | EVA | |
| rs478158060 | 401 | L>V | No | EVA | |
| rs448919073 | 403 | A>T | No | EVA | |
| rs483147408 | 408 | D>E | No | EVA | |
| rs458312700 | 411 | K>* | No | EVA | |
| rs479306767 | 415 | V>L | No | EVA | |
| rs714079633 | 418 | R>H | No | EVA | |
| rs460194971 | 428 | D>G | No | EVA | |
| rs441716084 | 431 | T>P | No | EVA | |
| rs474565561 | 432 | I>M | No | EVA | |
| rs456151411 | 437 | I>M | No | EVA | |
| rs444312775 | 448 | P>Q | No | EVA | |
| rs470867384 | 450 | F>C | No | EVA | |
| rs452452349 | 451 | Y>H | No | EVA | |
| rs208897965 | 453 | C>R | No | EVA | |
| rs454100452 | 454 | N>S | No | EVA | |
| rs435685975 | 464 | V>A | No | EVA | |
| rs444022443 | 477 | A>P | No | EVA | |
| rs470628203 | 480 | K>T | No | EVA | |
| rs440296108 | 482 | D>E | No | EVA | |
| rs452415057 | 482 | D>H | No | EVA | |
| rs473129628 | 483 | V>M | No | EVA | |
| rs454737085 | 484 | Q>K | No | EVA | |
| rs435645619 | 485 | I>N | No | EVA | |
| rs435645619 | 485 | I>T | No | EVA | |
| rs456523368 | 488 | L>P | No | EVA | |
| rs437950728 | 490 | L>P | No | EVA | |
| rs464404045 | 492 | Q>K | No | EVA | |
| rs446258748 | 493 | F>L | No | EVA | |
| rs434297849 | 497 | P>S | No | EVA | |
| rs448651787 | 499 | S>* | No | EVA | |
| rs481701018 | 506 | K>E | No | EVA | |
| rs462642078 | 506 | K>N | No | EVA | |
| rs450659328 | 507 | V>F | No | EVA | |
| rs458529709 | 508 | F>V | No | EVA | |
| rs448781670 | 515 | T>S | No | EVA | |
| rs481654503 | 517 | Q>* | No | EVA | |
| rs469907372 | 517 | Q>L | No | EVA | |
| rs445138958 | 525 | S>* | No | EVA | |
| rs478003622 | 526 | V>A | No | EVA | |
| rs440461298 | 533 | V>G | No | EVA | |
| rs799361930 | 535 | D>N | No | EVA | |
| rs479977674 | 548 | G>V | No | EVA | |
| rs457272948 | 560 | A>G | No | EVA | |
| rs443571122 | 565 | E>* | No | EVA | |
| rs109223030 | 570 | A>T | No | EVA | |
| rs442821744 | 573 | E>D | No | EVA | |
| rs456317013 | 596 | S>I | No | EVA | |
| rs470276650 | 597 | E>A | No | EVA | |
| rs437826665 | 597 | E>Q | No | EVA | |
| rs468700230 | 614 | L>P | No | EVA | |
| rs797966385 | 629 | N>T | No | EVA | |
| rs474777210 | 658 | T>A | No | EVA | |
| rs456362705 | 663 | I>R | No | EVA | |
| rs438016473 | 666 | A>E | No | EVA | |
| rs464864949 | 668 | R>G | No | EVA | |
| rs434132149 | 671 | L>F | No | EVA | |
| rs467171613 | 673 | L>P | No | EVA | |
| rs525047324 | 674 | Y>* | No | EVA | |
| rs452731639 | 681 | I>L | No | EVA | |
| rs467134512 | 689 | K>M | No | EVA | |
| rs455111612 | 689 | K>N | No | EVA | |
| rs436612986 | 694 | F>L | No | EVA | |
| rs469065223 | 695 | R>C | No | EVA | |
| rs450540166 | 695 | R>H | No | EVA | |
| rs476997027 | 698 | Q>H | No | EVA | |
| rs464926765 | 699 | K>* | No | EVA |
No associated diseases with Q3MHH2
1 regional properties for Q3MHH2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CCAAT-binding factor | 297 - 446 | IPR005612 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| t-UTP complex | A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
| positive regulation of transcription of nucleolar large rRNA by RNA polymerase I | Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADLEEGFAL | TAVPLGSGPD | GPLGVEQSGK | TDQFLVTDSG | RTVILYKVSD | QKPLGSWSVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QGQIITCPAV | CNFQTGEYIV | VHDNKVLRIW | NNEDVNLDKV | FKATLSAEVY | RIHSIQGTEP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVLFKEGAVR | GLEALLAEPQ | QKIETVISDE | EVIKWTKFFM | VFRHPVLIFI | TEKHGNYFVY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VQKFNSRILS | KYTLLLGQEE | KCVIQSFSTS | VGRKFISLMS | LSSDGCVYET | LIPIHPSEPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KNQRLVQSQL | LKSVVSGSAR | NGVALAILDQ | DHIAVLGAPL | PASKECLSVW | NTKFQTLQTS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KELPQGTSGQ | LWYYGENLFM | LHGKFLTVVP | FKCEVSSLAG | ALGKLKHSQD | PGIHATPHFV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NWETSQGCGL | GSQNSEQSKR | ILRRRKVEVS | VQPEVPASTQ | LLATIQKDSE | KHIEVELRKF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LATKRTPDFH | TIIGDVIIGL | LGRCKAEPSF | YPCNCLMQLV | QTHVLSYSLC | PGLMEFALEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TDVQILQLCL | QQFPDIPESV | TCACLKVFLS | IGDDTLQDTD | INMESVSDYM | DPVQDGEMEE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QTAFLQNGFS | PEEDNCDSCA | QKLKEKPQAA | ADESTSCPVT | PKRAALLNAV | LHSAYSETFL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LPHLKDIPAQ | HSTLFLQYLY | FLYLKCSENA | TMTLPGTHPP | TLSQIMDWIC | LLLDANFTVV |
| 670 | 680 | 690 | 700 | 710 | |
| VMIPEAKRLL | LSLYKFVKSQ | ISICSELNKI | EVSFRELQKL | NQEKNNRELY | SIEVLELF |