Q3B7D0

PR
Gene name
Cpox
Protein name
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Names
COX, Coprogen oxidase, Coproporphyrinogenase
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:304024
EC number
1.3.3.3: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-260 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3B7D0

Entry ID Method Resolution Chain Position Source
AF-Q3B7D0-F1 Predicted AlphaFoldDB

No variants for Q3B7D0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3B7D0

No associated diseases with Q3B7D0

1 regional properties for Q3B7D0

Type Name Position InterPro Accession
conserved_site Coproporphyrinogen III oxidase, conserved site 305 - 329 IPR018375

Functions

Description
EC Number 1.3.3.3 With oxygen as acceptor
Subcellular Localization
  • Mitochondrion intermembrane space
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
coproporphyrinogen oxidase activity Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX.
identical protein binding Binding to an identical protein or proteins.
protein homodimerization activity Binding to an identical protein to form a homodimer.
structural constituent of eye lens The action of a molecule that contributes to the structural integrity of the lens of an eye.

8 GO annotations of biological process

Name Definition
heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.
response to arsenic-containing substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
response to inorganic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
response to insecticide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
response to iron ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
response to lead ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
response to methylmercury Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9V3D2 Coprox Oxygen-dependent coproporphyrinogen-III oxidase Drosophila melanogaster (Fruit fly) PR
P36551 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial Homo sapiens (Human) PR
P36552 Cpox Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MALRLGQLGS GPWWRAVRGD YAQLRAPSPR SASACVCRLP GTAGTQPRRG LGHGSSAGGG
70 80 90 100 110 120
SRLGTGLAAA LAGMAGLAAA VLGHVQRAEM VPKSSGARSP SPGRLEEDGD ELARRCSTFM
130 140 150 160 170 180
SSPVTELREL GRRPDDMKTK MELMIMETQA QVCRALAQVD GVADFSVDRW ERKEGGGGIT
190 200 210 220 230 240
CVLQDGRVFE KAGVNISVVH GNLSEEAANQ MRSRGKALKK KDGKLPFTAM GISSVIHPKN
250 260 270 280 290 300
PYAPTMHFNY RYFEVEEADG KMHWWFGGGC DLTPTYLNRE DAVHFHRTLK EACDQHGPDI
310 320 330 340 350 360
YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV VPSYVPIVKK
370 380 390 400 410 420
HCDDSYTPQD KLWQQLRRGR YVEFNLVYDR GTKFGLFTPG SRIESILMSL PLTARWEYMH
430 440
SPPENSKEAE ILEVLRHPKD WVH