P36552
PR
Gene name |
Cpox (Cpo) |
Protein name |
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial |
Names |
COX, Coprogen oxidase, Coproporphyrinogenase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12892 |
EC number |
1.3.3.3: With oxygen as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P36552
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P36552-F1 | Predicted | AlphaFoldDB |
17 variants for P36552
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs266058099 | 11 | D>G | No | EVA | |
| rs227027115 | 29 | P>S | No | EVA | |
| rs226307362 | 62 | G>R | No | EVA | |
| rs253187077 | 66 | R>G | No | EVA | |
| rs255054911 | 162 | V>I | No | EVA | |
| rs3389437932 | 197 | S>T | No | EVA | |
| rs3389422780 | 204 | S>Y | No | EVA | |
| rs3413039336 | 225 | L>* | No | EVA | |
| rs3389431568 | 240 | N>I | No | EVA | |
| rs3389336877 | 244 | P>H | No | EVA | |
| rs3389401790 | 267 | G>R | No | EVA | |
| rs3389437948 | 300 | I>N | No | EVA | |
| rs3389412464 | 333 | S>F | No | EVA | |
| rs3389418667 | 333 | S>P | No | EVA | |
| rs3389389362 | 383 | E>Q | No | EVA | |
| rs3389412474 | 390 | R>W | No | EVA | |
| rs3389431606 | 416 | W>* | No | EVA |
No associated diseases with P36552
1 regional properties for P36552
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Coproporphyrinogen III oxidase, conserved site | 305 - 329 | IPR018375 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.3.3 | With oxygen as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial intermembrane space | The region between the inner and outer lipid bilayers of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| coproporphyrinogen oxidase activity | Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX. |
| identical protein binding | Binding to an identical protein or proteins. |
| P-type sodium:potassium-exchanging transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| structural constituent of eye lens | The action of a molecule that contributes to the structural integrity of the lens of an eye. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| heme biosynthetic process | The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. |
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| protoporphyrinogen IX biosynthetic process | The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. |
| response to arsenic-containing substance | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. |
| response to insecticide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. |
| response to iron ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. |
| response to lead ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. |
| response to methylmercury | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9V3D2 | Coprox | Oxygen-dependent coproporphyrinogen-III oxidase | Drosophila melanogaster (Fruit fly) | PR |
| P36551 | CPOX | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial | Homo sapiens (Human) | PR |
| Q3B7D0 | Cpox | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALRLGRLGS | DPWWRAVLGD | YAQLRAASPR | CASARVCQLP | GTAGPQPRRG | LGYGPWARGG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGLGTRLAAT | LAGLAGLAAA | AFGHVQRAEM | VPKSSGARSP | SPGRREEDGD | ELARRCSTFM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSPVTELREL | RRRPEDMKTK | MELMIMETQA | QVCRALAQVD | GVADFTVDRW | ERKEGGGGIT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CVLQDGRVFE | KAGVSISVVH | GNLSEEAANQ | MRGRGKTLKT | KDSKLPFTAM | GVSSVIHPKN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PYAPTMHFNY | RYFEVEEADG | NTHWWFGGGC | DLTPTYLNQE | DAVHFHRTLK | EACDQHGPDI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YPKFKKWCDD | YFFIVHRGER | RGIGGIFFDD | LDSPSKEEAF | RFVKTCAEAV | VPSYVPIVKK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HCDDSYTPRD | KLWQQLRRGR | YVEFNLLYDR | GTKFGLFTPG | SRIESILMSL | PLTARWEYMH |
| 430 | 440 | ||||
| SPPENSKEAE | ILEVLRHPKD | WVH |