Q39190
PR
Gene name |
PRL2 (At3g16650, MGL6.11) |
Protein name |
Protein pleiotropic regulator PRL2 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G16650 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q39190
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q39190-F1 | Predicted | AlphaFoldDB |
67 variants for Q39190
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_5671137_C_T | 2 | T>M | No | 1000Genomes | |
| ENSVATH05845399 | 4 | I>L | No | 1000Genomes | |
| ENSVATH00327505 | 4 | I>T | No | 1000Genomes | |
| ENSVATH05845400 | 8 | R>G | No | 1000Genomes | |
| ENSVATH05845401 | 8 | R>T | No | 1000Genomes | |
| ENSVATH10724428 | 18 | L>I | No | 1000Genomes | |
| ENSVATH05845402 | 19 | S>N | No | 1000Genomes | |
| ENSVATH02153262 | 23 | V>A | No | 1000Genomes | |
| ENSVATH00327506 | 29 | I>L | No | 1000Genomes | |
| ENSVATH05845403 | 35 | G>V | No | 1000Genomes | |
| ENSVATH05845404 | 37 | F>Y | No | 1000Genomes | |
| ENSVATH10724431 | 47 | I>T | No | 1000Genomes | |
| ENSVATH02153275 | 53 | I>V | No | 1000Genomes | |
| ENSVATH05845415 | 66 | P>A | No | 1000Genomes | |
| ENSVATH10724529 | 72 | H>R | No | 1000Genomes | |
| tmp_3_5671804_C_T | 72 | H>Y | No | 1000Genomes | |
| ENSVATH02153276 | 81 | K>N | No | 1000Genomes | |
| ENSVATH02153283 | 89 | K>E | No | 1000Genomes | |
| ENSVATH05845421 | 100 | E>A | No | 1000Genomes | |
| ENSVATH10724533 | 122 | K>Q | No | 1000Genomes | |
| ENSVATH02153291 | 123 | S>R | No | 1000Genomes | |
| ENSVATH02153292 | 124 | T>K | No | 1000Genomes | |
| tmp_3_5672397_G_A | 129 | A>T | No | 1000Genomes | |
| ENSVATH00327511 | 130 | P>S | No | 1000Genomes | |
| ENSVATH05845427 | 144 | M>I | No | 1000Genomes | |
| tmp_3_5672687_G_T | 151 | W>C | No | 1000Genomes | |
| ENSVATH02153300 | 162 | N>Y | No | 1000Genomes | |
| ENSVATH10724596 | 166 | L>F | No | 1000Genomes | |
| ENSVATH13932099 | 206 | L>I | No | 1000Genomes | |
| tmp_3_5673181_G_A | 210 | G>R | No | 1000Genomes | |
| tmp_3_5673199_C_G | 216 | R>G | No | 1000Genomes | |
| ENSVATH05845435 | 222 | N>Y | No | 1000Genomes | |
| tmp_3_5673397_A_T | 244 | N>I | No | 1000Genomes | |
| ENSVATH05845438 | 246 | V>I | No | 1000Genomes | |
| ENSVATH05845439 | 254 | L>S | No | 1000Genomes | |
| ENSVATH05845439 | 254 | L>W | No | 1000Genomes | |
| tmp_3_5673548_G_T | 261 | A>S | No | 1000Genomes | |
| tmp_3_5673593_T_A | 276 | S>T | No | 1000Genomes | |
| tmp_3_5673709_T_A | 281 | W>R | No | 1000Genomes | |
| tmp_3_5673722_C_T | 285 | T>M | No | 1000Genomes | |
| tmp_3_5673728_T_C | 287 | M>T | No | 1000Genomes | |
| ENSVATH05845446 | 288 | Q>E | No | 1000Genomes | |
| tmp_3_5673752_A_G | 295 | D>G | No | 1000Genomes | |
| ENSVATH05845448 | 303 | A>P | No | 1000Genomes | |
| tmp_3_5673776_C_T | 303 | A>V | No | 1000Genomes | |
| ENSVATH10724598 | 304 | R>L | No | 1000Genomes | |
| tmp_3_5674084_C_T | 329 | S>L | No | 1000Genomes | |
| ENSVATH05845451 | 332 | T>I | No | 1000Genomes | |
| ENSVATH00327528 | 351 | D>A | No | 1000Genomes | |
| tmp_3_5674240_G_A | 355 | A>T | No | 1000Genomes | |
| ENSVATH05845452 | 364 | S>N | No | 1000Genomes | |
| tmp_3_5674299_G_A | 374 | M>I | No | 1000Genomes | |
| ENSVATH05845454 | 379 | R>K | No | 1000Genomes | |
| tmp_3_5674470_A_T | 383 | N>I | No | 1000Genomes | |
| ENSVATH02153317 | 384 | A>T | No | 1000Genomes | |
| ENSVATH05845455 | 385 | V>M | No | 1000Genomes | |
| tmp_3_5674502_G_A | 394 | V>I | No | 1000Genomes | |
| tmp_3_5674663_T_G | 403 | W>G | No | 1000Genomes | |
| ENSVATH05845461 | 424 | S>T | No | 1000Genomes | |
| tmp_3_5674948_G_A | 428 | E>K | No | 1000Genomes | |
| ENSVATH02153324 | 433 | A>V | No | 1000Genomes | |
| tmp_3_5674982_C_T | 439 | T>M | No | 1000Genomes | |
| tmp_3_5674985_G_A | 440 | G>D | No | 1000Genomes | |
| ENSVATH02153325 | 446 | C>S | No | 1000Genomes | |
| tmp_3_5675008_G_A | 448 | G>R | No | 1000Genomes | |
| ENSVATH00327534 | 448 | G>V | No | 1000Genomes | |
| ENSVATH05845462 | 460 | D>N | No | 1000Genomes |
No associated diseases with Q39190
8 regional properties for Q39190
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 159 - 364 | IPR001680-1 |
| repeat | WD40 repeat | 368 - 406 | IPR001680-2 |
| repeat | WD40 repeat | 418 - 456 | IPR001680-3 |
| conserved_site | WD40 repeat, conserved site | 269 - 283 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 310 - 324 | IPR019775-2 |
| repeat | G-protein beta WD-40 repeat | 185 - 199 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 269 - 283 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 310 - 324 | IPR020472-3 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| Cul4-RING E3 ubiquitin ligase complex | A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. |
| Prp19 complex | A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12417 | PRP46 | Pre-mRNA-splicing factor PRP46 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTMIALNREV | ETQSLKKLSL | KSVRRAREIF | SPVHGQFPQP | DPESKRIRLC | HKIQVAFGGV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EPASKPTRIA | DHNSEKTAPL | KALALPGPKG | SKELRKSATE | KALVVGPTLP | PRDLNNTGNP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GKSTAILPAP | GSFSERNLST | AALMERMPSR | WPRPEWHAPW | KNYRVLQGHL | GWVRSVAFDP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SNEWFCTGSA | DRTIKIWDVA | TGVLKLTLTG | HIGQVRGLAV | SNRHTYMFSA | GDDKQVKCWD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LEQNKVIRSY | HGHLHGVYCL | ALHPTLDVVL | TGGRDSVCRV | WDIRTKMQIF | VLPHDSDVFS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VLARPTDPQV | ITGSHDSTIK | FWDLRYGKSM | ATITNHKKTV | RAMALHPKEN | DFVSASADNI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KKFSLPKGEF | CHNMLSLQRD | IINAVAVNED | GVMVTGGDKG | GLWFWDWKSG | HNFQRAETIV |
| 430 | 440 | 450 | 460 | 470 | |
| QPGSLESEAG | IYAACYDQTG | SRLVTCEGDK | TIKMWKEDED | ATPETHPLNF | KPPKEIRRF |