Q12417
Gene name |
PRP46 (CWC1, NTC50, YPL151C, P2594) |
Protein name |
Pre-mRNA-splicing factor PRP46 |
Names |
Complexed with CEF1 protein 1, PRP nineteen-associated complex protein 50, PRP19-associated complex protein 50, Pre-mRNA-processing protein 46 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPL151C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
17 structures for Q12417
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5GM6 | EM | 350 A | O | 1-451 | PDB |
| 5GMK | EM | 340 A | O | 1-451 | PDB |
| 5LJ3 | EM | 380 A | J | 1-451 | PDB |
| 5LJ5 | EM | 380 A | J | 1-451 | PDB |
| 5LQW | EM | 580 A | K | 1-451 | PDB |
| 5MPS | EM | 385 A | J | 1-451 | PDB |
| 5MQ0 | EM | 417 A | J | 1-451 | PDB |
| 5WSG | EM | 400 A | O | 1-451 | PDB |
| 5Y88 | EM | 370 A | O | 1-451 | PDB |
| 5YLZ | EM | 360 A | O | 1-451 | PDB |
| 6BK8 | EM | 330 A | D | 1-451 | PDB |
| 6EXN | EM | 370 A | J | 1-451 | PDB |
| 6J6G | EM | 320 A | O | 1-451 | PDB |
| 6J6H | EM | 360 A | O | 1-451 | PDB |
| 6J6N | EM | 386 A | O | 1-451 | PDB |
| 6J6Q | EM | 370 A | O | 1-451 | PDB |
| AF-Q12417-F1 | Predicted | AlphaFoldDB |
10 variants for Q12417
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-267298 | 79 | E>D | No | SGRP | |
| s16-267297 | 80 | A>T | No | SGRP | |
| s16-267268 | 89 | D>E | No | SGRP | |
| s16-267043 | 164 | M>I | No | SGRP | |
| s16-267000 | 179 | A>T | No | SGRP | |
| s16-266706 | 277 | V>I | No | SGRP | |
| s16-266517 | 340 | S>P | No | SGRP | |
| s16-266421 | 372 | V>M | No | SGRP | |
| s16-266378 | 386 | S>L | No | SGRP | |
| s16-266310 | 409 | K>E | No | SGRP |
No associated diseases with Q12417
8 regional properties for Q12417
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 128 - 335 | IPR001680-1 |
| repeat | WD40 repeat | 338 - 377 | IPR001680-2 |
| repeat | WD40 repeat | 389 - 427 | IPR001680-3 |
| conserved_site | WD40 repeat, conserved site | 239 - 253 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 281 - 295 | IPR019775-2 |
| repeat | G-protein beta WD-40 repeat | 155 - 169 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 239 - 253 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 281 - 295 | IPR020472-3 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| Prp19 complex | A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q39190 | PRL2 | Protein pleiotropic regulator PRL2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDGNDHKVEN | LGDVDKFYSR | IRWNNQFSYM | ATLPPHLQSE | MEGQKSLLMR | YDTYRKESSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FSGEGKKVTL | QHVPTDFSEA | SQAVISKKDH | DTHASAFVNK | IFQPEVAEEL | IVNRYEKLLS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QRPEWHAPWK | LSRVINGHLG | WVRCVAIDPV | DNEWFITGSN | DTTMKVWDLA | TGKLKTTLAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HVMTVRDVAV | SDRHPYLFSV | SEDKTVKCWD | LEKNQIIRDY | YGHLSGVRTV | SIHPTLDLIA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TAGRDSVIKL | WDMRTRIPVI | TLVGHKGPIN | QVQCTPVDPQ | VVSSSTDATV | RLWDVVAGKT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MKVLTHHKRS | VRATALHPKE | FSVASACTDD | IRSWGLAEGS | LLTNFESEKT | GIINTLSINQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DDVLFAGGDN | GVLSFYDYKS | GHKYQSLATR | EMVGSLEGER | SVLCSTFDKT | GLRLITGEAD |
| 430 | 440 | 450 | |||
| KSIKIWKQDE | TATKESEPGL | AWNPNLSAKR | F |