Q33DR2
Gene name |
Pdss1 |
Protein name |
All trans-polyprenyl-diphosphate synthase PDSS1 |
Names |
All-trans-decaprenyl-diphosphate synthase subunit 1, Decaprenyl-diphosphate synthase subunit 1, Solanesyl-diphosphate synthase subunit 1, Trans-prenyltransferase 1, TPT 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56075 |
EC number |
2.5.1.91: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q33DR2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q33DR2-F1 | Predicted | AlphaFoldDB |
21 variants for Q33DR2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1132205163 | 4 | R>H | No | EVA | |
| rs3391340348 | 8 | W>R | No | EVA | |
| rs3391342976 | 8 | W>S | No | EVA | |
| rs3391361080 | 9 | R>P | No | EVA | |
| rs3388530889 | 21 | S>C | No | EVA | |
| rs247403468 | 22 | P>L | No | EVA | |
| rs263478551 | 24 | R>P | No | EVA | |
| rs3388532830 | 30 | V>M | No | EVA | |
| rs3388530260 | 61 | M>I | No | EVA | |
| rs3412781068 | 61 | M>L | No | EVA | |
| rs3388530976 | 164 | E>* | No | EVA | |
| rs3388531979 | 212 | A>D | No | EVA | |
| rs3388530918 | 232 | L>M | No | EVA | |
| rs3388530310 | 277 | C>S | No | EVA | |
| rs3388526477 | 281 | V>M | No | EVA | |
| rs3388533683 | 331 | L>S | No | EVA | |
| rs3388530861 | 353 | D>H | No | EVA | |
| rs3388531931 | 357 | A>V | No | EVA | |
| rs3388530966 | 363 | Q>H | No | EVA | |
| rs3388528706 | 401 | S>* | No | EVA | |
| rs3388528758 | 408 | D>E | No | EVA |
No associated diseases with Q33DR2
2 regional properties for Q33DR2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Polyprenyl synthetase, conserved site | 171 - 185 | IPR033749-1 |
| conserved_site | Polyprenyl synthetase, conserved site | 293 - 305 | IPR033749-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.91 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| transferase complex | A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| all-trans-decaprenyl-diphosphate synthase activity | Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate. |
| all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity | Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate. |
| metal ion binding | Binding to a metal ion. |
| prenyltransferase activity | Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| trans-hexaprenyltranstransferase activity | Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| isoprenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. |
| ubiquinone biosynthetic process | The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAMRWSCWRR | GCSWRPTAVG | SPRRERPGCV | EPLGTRAASD | TRAQIPYFSL | MKILMSASPT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MHSISQFHQR | TPAMCSCRQT | QSGEKYSDPF | KLGWRDLKGL | YEDIRKELHI | STRELKDMSE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YYFDGKGKAF | RPIIVVLMAR | ACNIHHNNAR | EMQASQRSIA | LVAEMIHTAT | LVHDDVIDDA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSRRGKHTVN | KIWGEKKAVL | AGDLILSAAS | VALARIGNTA | VVSMLAQVIE | DLVRGEFLQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GSKENENERF | AHYLEKTFKK | TASLIANSCK | AVSVLGCPDP | VVHEIAYQYG | KNVGIAFQLI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DDVLDFTSCS | DQMGKPTSAD | LKLGIATGPV | LFACQQFPEM | NAMIMRRFSL | PGDVDRARQY |
| 370 | 380 | 390 | 400 | ||
| VLQSDGVQQT | TYLAQQYCHK | AVREIRKLRP | STERDALIQL | SESVLTRDK |