O22043
PR
Gene name |
GGPP6 |
Protein name |
Geranylgeranyl pyrophosphate synthase 6, mitochondrial |
Names |
GGPP synthase 6, GGPS6, (2E,6E)-farnesyl diphosphate synthase 6, Dimethylallyltranstransferase 6, Farnesyl diphosphate synthase 6, Farnesyltranstransferase 6, Geranyltranstransferase 6 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G49530 |
EC number |
2.5.1.1: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O22043
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O22043-F1 | Predicted | AlphaFoldDB |
67 variants for O22043
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01329329 | 4 | R>C | No | 1000Genomes | |
| ENSVATH01329331 | 8 | I>F | No | 1000Genomes | |
| ENSVATH01329331 | 8 | I>V | No | 1000Genomes | |
| tmp_1_18332559_G_A | 11 | A>T | No | 1000Genomes | |
| tmp_1_18332578_C_T | 17 | P>L | No | 1000Genomes | |
| ENSVATH04915769 | 21 | R>L | No | 1000Genomes | |
| ENSVATH00089813 | 23 | S>C | No | 1000Genomes | |
| ENSVATH14270911 | 24 | S>A | No | 1000Genomes | |
| tmp_1_18332607_A_G | 27 | S>G | No | 1000Genomes | |
| tmp_1_18332611_C_T | 28 | S>F | No | 1000Genomes | |
| ENSVATH01329332 | 28 | S>P | No | 1000Genomes | |
| ENSVATH13465376 | 29 | D>E | No | 1000Genomes | |
| ENSVATH01329333 | 37 | K>* | No | 1000Genomes | |
| ENSVATH01329334 | 37 | K>N | No | 1000Genomes | |
| ENSVATH04915770 | 39 | K>* | No | 1000Genomes | |
| ENSVATH04915771 | 44 | N>D | No | 1000Genomes | |
| tmp_1_18332661_A_G | 45 | K>E | No | 1000Genomes | |
| tmp_1_18332670_G_A | 48 | D>N | No | 1000Genomes | |
| ENSVATH13465377 | 53 | L>F | No | 1000Genomes | |
| ENSVATH01329336 | 57 | F>S | No | 1000Genomes | |
| tmp_1_18332709_T_A | 61 | W>R | No | 1000Genomes | |
| ENSVATH04915772 | 65 | L>R | No | 1000Genomes | |
| ENSVATH00089815 | 77 | P>S | No | 1000Genomes | |
| ENSVATH00089817 | 82 | V>A | No | 1000Genomes | |
| tmp_1_18332817_C_A | 97 | Q>K | No | 1000Genomes | |
| tmp_1_18332820_G_T | 98 | E>* | No | 1000Genomes | |
| tmp_1_18332838_G_A | 104 | A>T | No | 1000Genomes | |
| tmp_1_18332845_G_C | 106 | C>S | No | 1000Genomes | |
| ENSVATH13465395 | 111 | I>T | No | 1000Genomes | |
| ENSVATH14270912 | 116 | L>P | No | 1000Genomes | |
| ENSVATH14270913 | 123 | C>S | No | 1000Genomes | |
| ENSVATH04915775 | 129 | L>F | No | 1000Genomes | |
| tmp_1_18332916_C_T | 130 | R>C | No | 1000Genomes | |
| ENSVATH01329338 | 133 | K>I | No | 1000Genomes | |
| ENSVATH01329339 | 134 | P>S | No | 1000Genomes | |
| ENSVATH14270914 | 138 | K>* | No | 1000Genomes | |
| tmp_1_18332943_G_T | 139 | V>F | No | 1000Genomes | |
| ENSVATH14270935 | 142 | E>V | No | 1000Genomes | |
| ENSVATH04915776 | 143 | K>E | No | 1000Genomes | |
| ENSVATH00089819 | 153 | R>M | No | 1000Genomes | |
| ENSVATH14270937 | 159 | Q>L | No | 1000Genomes | |
| tmp_1_18333007_CA_TA,C | 160 | T>I | No | 1000Genomes | |
| tmp_1_18333012_G_A | 162 | A>T | No | 1000Genomes | |
| tmp_1_18333030_G_T | 168 | V>L | No | 1000Genomes | |
| tmp_1_18333033_A_T | 169 | T>S | No | 1000Genomes | |
| ENSVATH04915777 | 175 | R>G | No | 1000Genomes | |
| ENSVATH04915777 | 175 | R>W | No | 1000Genomes | |
| ENSVATH14270939 | 180 | M>I | No | 1000Genomes | |
| tmp_1_18333078_G_C | 184 | V>L | No | 1000Genomes | |
| tmp_1_18333109_C_T | 194 | A>V | No | 1000Genomes | |
| ENSVATH07639320 | 198 | A>T | No | 1000Genomes | |
| ENSVATH01329345 | 205 | K>E | No | 1000Genomes | |
| ENSVATH01329346 | 207 | E>K | No | 1000Genomes | |
| ENSVATH01329347 | 209 | D>N | No | 1000Genomes | |
| ENSVATH01329349 | 219 | V>I | No | 1000Genomes | |
| ENSVATH04915778 | 227 | E>V | No | 1000Genomes | |
| ENSVATH01329350 | 228 | A>S | No | 1000Genomes | |
|
ENSVATH01329352 ENSVATH14270942 |
249 | S>R | No | 1000Genomes | |
| tmp_1_18333314_T_G | 262 | D>E | No | 1000Genomes | |
| tmp_1_18333340_C_T | 271 | S>F | No | 1000Genomes | |
| ENSVATH13465397 | 288 | T>M | No | 1000Genomes | |
| ENSVATH13465398 | 301 | Y>C | No | 1000Genomes | |
| tmp_1_18333483_G_A | 319 | D>N | No | 1000Genomes | |
| ENSVATH04915781 | 319 | D>V | No | 1000Genomes | |
| ENSVATH00089822 | 322 | V>F | No | 1000Genomes | |
| tmp_1_18333500_G_C | 324 | L>F | No | 1000Genomes | |
| tmp_1_18333536_C_A | 336 | N>K | No | 1000Genomes |
No associated diseases with O22043
2 regional properties for O22043
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Polyprenyl synthetase, conserved site | 116 - 132 | IPR033749-1 |
| conserved_site | Polyprenyl synthetase, conserved site | 254 - 266 | IPR033749-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.1 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| dimethylallyltranstransferase activity | Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. |
| farnesyltranstransferase activity | Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| geranyltranstransferase activity | Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate. |
| metal ion binding | Binding to a metal ion. |
| prenyltransferase activity | Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| carotenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. |
| farnesyl diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of farnesyl diphosphate. |
| geranyl diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of geranyl diphosphate. |
| geranylgeranyl diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate. |
| isoprenoid biosynthetic process | The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRPRYSLILS | AMRLIRPSNR | RLSSIASSDS | EFISYMKNKA | KSINKALDNS | IPLCNNFVPL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WEPVLEVHKA | MRYTLLPGGK | RVRPMLCLVA | CELVGGQEST | AMPAACAVEM | IHAASLILDD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPCMDDDSLR | RGKPTNHKVF | GEKTSILASN | ALRSLAVKQT | LASTSLGVTS | ERVLRAVQEM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARAVGTEGLV | AGQAADLAGE | RMSFKNEDDE | LRYLELMHVH | KTAVLVEAAA | VVGAIMGGGS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DEEIERLKSY | ARCVGLMFQV | MDDVLDETKS | SEELGKTAGK | DLITGKLTYP | KVMGVDNARE |
| 310 | 320 | 330 | |||
| YAKRLNREAQ | EHLQGFDSDK | VVPLLSLADY | IVKRQN |