AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-59 (Predicted disordered autoinhibitory region) PR

1-59 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q32LB5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs109044971	6	K>N	No	EVA
rs380564947	26	A>V	No	EVA
rs439728000	46	R>W	No	EVA
rs453313249	47	T>A	No	EVA
rs441957945	57	K>Q	No	EVA
rs433708821	68	T>S	No	EVA
rs457910983	76	C>S	No	EVA
rs453680790	97	A>S	No	EVA
rs473633711	108	I>R	No	EVA
rs456691187	110	A>E	No	EVA
rs478039961	110	A>P	No	EVA
rs476660674	111	A>E	No	EVA
rs438991402	136	C>G	No	EVA
rs459182545	137	G>V	No	EVA
rs472773318	139	Y>*	No	EVA
rs441328545	141	Q>E	No	EVA
rs378441033	175	A>V	No	EVA
rs454698881	181	M>L	No	EVA
rs461639792	187	G>V	No	EVA
rs714050288	192	M>R	No	EVA
rs474662721	195	G>E	No	EVA
rs457973657	204	R>G	No	EVA
rs436737496	207	E>G	No	EVA
rs799063319	208	R>H	No	EVA
rs384405022	215	P>L	No	EVA
rs721853679	222	T>I	No	EVA
rs714931368	223	R>S	No	EVA

Type	Name	Position	InterPro Accession
domain	CAP domain	33 - 180	IPR014044
conserved_site	Allergen V5/Tpx-1-related, conserved site	137 - 147	IPR018244-1
conserved_site	Allergen V5/Tpx-1-related, conserved site	167 - 178	IPR018244-2
domain	Glioma pathogenesis-related protein 1-like, SCP domain	33 - 176	IPR034121

		Description
EC Number
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle, acrosome Cell membrane ; Lipid-anchor, GPI-anchor Membrane raft	Located in the connecting piece of elongated spermatids and sperm (By similarity) Also located in the apical region of the sperm head after sperm capacitation (By similarity) Located on sperm equatorial segment and neck (PubMed:22552861) Associated with epididymosomes from the caput and cauda epididymis (PubMed:22552861)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
acrosomal vesicle	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
anchored component of membrane	The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
No GO annotations for molecular function

Name	Definition
binding of sperm to zona pellucida	The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q4G1C9	GLIPR1L2	GLIPR1-like protein 2	Homo sapiens (Human)	PR
Q9CQ35	Glipr1l2	GLIPR1-like protein 2	Mus musculus (Mouse)	PR
Q8BS03	Pi15	Peptidase inhibitor 15	Mus musculus (Mouse)	PR