Q32KZ2

PR
Gene name
ACTL7A
Protein name
Actin-like protein 7A
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:540296
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-141 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q32KZ2

Entry ID Method Resolution Chain Position Source
AF-Q32KZ2-F1 Predicted AlphaFoldDB

85 variants for Q32KZ2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs453439644 10 Q>P No EVA
rs473542822 13 V>G No EVA
rs435801811 22 V>E No EVA
rs455978108 24 E>D No EVA
rs476085510 27 S>P No EVA
rs444778324 35 T>P No EVA
rs470420901 42 P>Q No EVA
rs459305662 49 V>E No EVA
rs1117519750 52 D>N No EVA
rs479381586 63 E>* No EVA
rs448172808 81 T>P No EVA
rs461982617 83 Y>S No EVA
rs450809072 89 A>S No EVA
rs446932731 93 K>N No EVA
rs433155150 93 K>T No EVA
rs467081364 95 T>S No EVA
rs435716985 102 V>G No EVA
rs455856397 118 E>A No EVA
rs469644322 118 E>D No EVA
rs459876001 124 E>* No EVA
rs470381712 124 E>A No EVA
rs439178954 124 E>D No EVA
rs459876001 124 E>K No EVA
rs441750947 135 I>V No EVA
rs461907852 136 N>I No EVA
rs482076853 148 T>S No EVA
rs444298641 149 V>M No EVA
rs458051072 152 I>L No EVA
rs478162005 160 E>* No EVA
rs446846744 167 E>* No EVA
rs466995088 180 H>P No EVA
rs449379019 186 Y>H No EVA
rs465483257 188 E>D No EVA
rs451859069 188 E>G No EVA
rs434277049 189 M>L No EVA
rs473074550 193 T>P No EVA
rs455426138 194 F>L No EVA
rs441651001 194 F>Y No EVA
rs475577238 196 T>P No EVA
rs478074247 198 A>G No EVA
rs457963414 198 A>P No EVA
rs460464444 199 M>I No EVA
rs440376177 199 M>R No EVA
rs480656314 200 H>P No EVA
rs449265172 201 I>F No EVA
rs469517604 201 I>T No EVA
rs445382194 202 A>P No EVA
rs465446470 203 Y>H No EVA
rs434238007 203 Y>S No EVA
rs133499504 205 S>P No EVA
rs466478318 210 Y>S No EVA
rs455310053 212 Y>D No EVA
rs437722627 213 G>C No EVA
rs451514841 215 T>N No EVA
rs471603409 219 V>G No EVA
rs440288222 220 V>A No EVA
rs440288222 220 V>G No EVA
rs474174283 222 V>G No EVA
rs482924563 224 H>N No EVA
rs445341298 224 H>P No EVA
rs482924563 224 H>Y No EVA
rs458939035 225 G>D No EVA
rs479015862 226 V>G No EVA
rs447857803 227 S>A No EVA
rs468106403 227 S>C No EVA
rs436712035 228 Y>H No EVA
rs448843024 229 V>I No EVA
rs448843024 229 V>L No EVA
rs468997165 230 V>G No EVA
rs451426835 231 P>H No EVA
rs437657320 231 P>S No EVA
rs471566665 236 Y>D No EVA
rs433780859 237 P>T No EVA
rs453876625 242 T>P No EVA
rs1114624969 244 R>L No EVA
rs474105532 246 D>A No EVA
rs442742780 266 H>D No EVA
rs462951371 274 I>S No EVA
rs134923277 275 V>M No EVA
rs438811044 295 V>D No EVA
rs458898462 305 T>P No EVA
rs478976799 367 S>R No EVA
rs441385858 385 C>S No EVA
rs481763773 402 V>M No EVA
rs450338284 437 C>S No EVA

No associated diseases with Q32KZ2

1 regional properties for Q32KZ2

Type Name Position InterPro Accession
domain Actin-like protein 7A, N-terminal 6 - 68 IPR031769

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Golgi apparatus
  • Cytoplasm
  • Nucleus
  • Detected at the Golgi apparatus during acrosome biogenesis
  • Detected at the subacrosomal layer in round spermatids
  • Detected in sperm head and tail
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
acrosomal vesicle A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dynactin complex A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
male germ cell nucleus The nucleus of a male germ cell, a reproductive cell in males.
motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
acrosome assembly The formation of the acrosome from the spermatid Golgi.
fertilization The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
single fertilization The union of male and female gametes to form a zygote.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y614 ACTL7B Actin-like protein 7B Homo sapiens (Human) PR
Q9H568 ACTL8 Actin-like protein 8 Homo sapiens (Human) PR
Q9Y615 ACTL7A Actin-like protein 7A Homo sapiens (Human) PR
Q9QY83 Actl7b Actin-like protein 7B Mus musculus (Mouse) PR
Q4QR76 Actl7b Actin-like protein 7B Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MALESVWAPQ AAVIGDGLSE RVGEQASPQT QVLQTASLKD GPAKRAVWVR RDHSEPEPTT
70 80 90 100 110 120
SPEVKKPKLE LTKAVVVDLG TGYCKCGFAG LPKPTHRIST TVGKPYMETA KTGDNRKETF
130 140 150 160 170 180
VGHELINPEV RLKLINPLRH GIIVDWDTVQ DIWEYLFHQE MKIAPEEHAV LVSDPPLSPH
190 200 210 220 230 240
TNREKYAEML FETFKTPAMH IAYQSRLSMY SYGRTSGLVV EVGHGVSYVV PIYEGYPLPS
250 260 270 280 290 300
ITGRLDYAGS DLTTYLMCLM NTAGKHFTEG QLGIVEDIKK KCCFVALDPI EEKKVPATEH
310 320 330 340 350 360
MIQYTLPDGQ AIYLCQERFL CSEMFFKPSL IKSMQLGLHT QTVSCLNKCD IALKRDLMGN
370 380 390 400 410 420
ILLCGGSTML SGFPNRLQKE LSSMCPNDTP QVSVLPERDT AVWTGGSILA SLQGFQPLWV
430
HRSEYEEHGP FFLYRRCF