Q2TBX0

PR
Gene name
ZNF259 (ZPR1)
Protein name
Zinc finger protein ZPR1
Names
Zinc finger protein 259
Species
Bos taurus (Bovine)
KEGG Pathway
bta:504523
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2TBX0

Entry ID Method Resolution Chain Position Source
AF-Q2TBX0-F1 Predicted AlphaFoldDB

90 variants for Q2TBX0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs463649333 2 S>P No EVA
rs134379106 6 A>G No EVA
rs136640523 7 V>G No EVA
rs455137217 8 E>D No EVA
rs135068255 8 E>G No EVA
rs133590227 9 P>A No EVA
rs470478959 10 G>E No EVA
rs136133528 11 L>P No EVA
rs135224190 13 A>G No EVA
rs433359926 15 A>P No EVA
rs433359926 15 A>S No EVA
rs447909769 19 S>P No EVA
rs480679798 20 A>G No EVA
rs450046344 23 A>G No EVA
rs463659663 24 R>P No EVA
rs438647651 25 D>A No EVA
rs478152949 25 D>E No EVA
rs438647651 25 D>G No EVA
rs438647651 25 D>V No EVA
rs459352714 27 G>A No EVA
rs473684844 28 P>R No EVA
rs443207752 30 H>D No EVA
rs438867797 30 H>P No EVA
rs476246302 31 L>M No EVA
rs433445681 33 R>P No EVA
rs454307915 36 S>R No EVA
rs479765995 37 A>D No EVA
rs435807112 39 D>V No EVA
rs468668742 41 E>Q No EVA
rs450144822 47 I>T No EVA
rs438101134 52 M>T No EVA
rs464480868 53 N>T No EVA
rs446045677 54 C>R No EVA
rs477869389 55 Y>S No EVA
rs468442489 61 R>G No EVA
rs437899069 79 S>Y No EVA
rs464319053 81 E>* No EVA
rs445888172 81 E>D No EVA
rs478673799 86 N>D No EVA
rs448061271 87 N>K No EVA
rs466700900 87 N>S No EVA
rs481103392 90 I>S No EVA
rs463203620 96 I>V No EVA
rs451138046 97 Q>P No EVA
rs477758010 98 D>G No EVA
rs440579962 101 V>G No EVA
rs461328072 104 T>N No EVA
rs473283924 104 T>P No EVA
rs442785723 105 L>R No EVA
rs457276730 111 E>G No EVA
rs438433959 142 A>V No EVA
rs471327969 144 T>A No EVA
rs434378982 145 T>A No EVA
rs468094063 147 E>Q No EVA
rs437499885 148 G>V No EVA
rs479676279 150 I>S No EVA
rs470325061 151 S>C No EVA
rs445479552 155 S>A No EVA
rs466300215 156 G>S No EVA
rs480655043 157 L>V No EVA
rs462162790 159 Q>P No EVA
rs449036246 160 D>E No EVA
rs527152446 218 V>L No EVA
rs457734223 224 R>Q No EVA
rs208297208 244 E>D No EVA
rs468759493 328 S>F No EVA
rs456795597 329 E>G No EVA
rs465525967 330 T>A No EVA
rs446996826 330 T>K No EVA
rs468001905 345 A>S No EVA
rs133502836 346 V>G No EVA
rs463715509 357 M>I No EVA
rs482389626 357 M>R No EVA
rs477282347 358 L>P No EVA
rs458880329 362 R>Q No EVA
rs440181456 363 E>D No EVA
rs473137999 364 L>M No EVA
rs454355651 419 A>T No EVA
rs435998290 424 P>A No EVA
rs435998290 424 P>T No EVA
rs475903988 426 M>V No EVA
rs457437166 428 V>A No EVA
rs457437166 428 V>G No EVA
rs447047674 428 V>L No EVA
rs432686263 441 L>R No EVA
rs447073108 443 L>V No EVA
rs467934952 444 N>K No EVA
rs434857218 444 N>T No EVA
rs449288598 445 D>E No EVA
rs463754289 460 R>E No EVA

No associated diseases with Q2TBX0

2 regional properties for Q2TBX0

Type Name Position InterPro Accession
domain Zinc finger, ZPR1-type 49 - 237 IPR004457-1
domain Zinc finger, ZPR1-type 257 - 449 IPR004457-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Nucleus, nucleolus
  • Cytoplasm, perinuclear region
  • Nucleus, gem
  • Nucleus, Cajal body
  • Cell projection, axon
  • Cell projection, growth cone
  • Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle
  • Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle
  • Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle
  • Diffusely localized throughout the cell during mitosis
  • Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner
  • Colocalized with EGFR in the cytoplasm of quiescent cells
  • Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner
  • Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens
  • Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
Cajal body A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Gemini of coiled bodies Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA).
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

3 GO annotations of molecular function

Name Definition
receptor tyrosine kinase binding Binding to a receptor that possesses protein tyrosine kinase activity.
translation initiation factor binding Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
zinc ion binding Binding to a zinc ion (Zn).

20 GO annotations of biological process

Name Definition
apoptotic process involved in development Any apoptotic process that is involved in anatomical structure development.
axon development The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).
Cajal body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors.
cellular response to epidermal growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
DNA endoreduplication Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.
inner cell mass cell proliferation The proliferation of cells in the inner cell mass.
microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
negative regulation of motor neuron apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process.
positive regulation of cell cycle Any process that activates or increases the rate or extent of progression through the cell cycle.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of growth Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.
positive regulation of protein import into nucleus Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
positive regulation of RNA splicing Any process that activates or increases the frequency, rate or extent of RNA splicing.
positive regulation of transcription involved in G1/S transition of mitotic cell cycle Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle.
pre-mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA).
regulation of myelination Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
spinal cord development The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
trophectodermal cell proliferation The proliferation of cells in the trophectoderm.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53303 ZPR1 Zinc finger protein ZPR1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O75312 ZPR1 Zinc finger protein ZPR1 Homo sapiens (Human) PR
10 20 30 40 50 60
MSAGGAVEPG LPAAAAAPSA APARDPGPGH LFRPISAEDE EQQPTEIESL CMNCYRNGMT
70 80 90 100 110 120
RLLLTKIPFF REIIVSSFSC EHCGWNNTEI QSAGRIQDQG VRYTLTVRAQ EDMDREVVKT
130 140 150 160 170 180
DSATTRIPEL DFEIPAFSQK GALTTVEGLI SRAISGLEQD QPTRRANEEA VAERIDEFIA
190 200 210 220 230 240
KLKELKQVAS PFTLIIDDPS GNSFVENPHA PRKDDALVIT HYNRTLQQEE MLGLQAEAPE
250 260 270 280 290 300
EKPEEEDIRN EVLQFNTNCP ECNAPAQTNM KLVQIPHFKE VIIMATNCEN CGHRTNEVKS
310 320 330 340 350 360
GGAVEPLGTR ITFHITDPSD MTRDLLKSET CSVEIPELEF ELGMAVLGGK FTTLEGMLKD
370 380 390 400 410 420
IRELVTKNPF TLGDSSSPGQ TEKLQEFSQK LDQILEGILK AHFIMDDPAG NSYLQNVYAP
430 440 450
EDDPEMKVEH YKRTFDQNEE LGLNDMKTEG YETGLPAQR