Q29549

PR
Gene name
CLU
Protein name
Clusterin
Names
CP40, Complement cytolysis inhibitor, CLI
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397025
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q29549

Entry ID Method Resolution Chain Position Source
AF-Q29549-F1 Predicted AlphaFoldDB

No variants for Q29549

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q29549

No associated diseases with Q29549

4 regional properties for Q29549

Type Name Position InterPro Accession
domain Clusterin, N-terminal 23 - 227 IPR016014
domain Clusterin, C-terminal 228 - 440 IPR016015
conserved_site Clusterin, conserved site 113 - 121 IPR033986-1
conserved_site Clusterin, conserved site 294 - 304 IPR033986-2

Functions

Description
EC Number
Subcellular Localization
  • Secreted
  • Nucleus
  • Cytoplasm
  • Mitochondrion membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm, cytosol
  • Microsome
  • Endoplasmic reticulum
  • Mitochondrion
  • Mitochondrion membrane
  • Cytoplasm, perinuclear region
  • Cytoplasmic vesicle, secretory vesicle, chromaffin granule
  • Can retrotranslocate from the secretory compartments to the cytosol upon cellular stress
  • Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins
  • Detected at the mitochondrion membrane upon induction of apoptosis
  • Under ER stress, a immaturely glycosylated pre-secreted form retrotranslocates from the endoplasmic reticulum (ER)-Golgi network to the cytoplasm to localize in the mitochondria through HSPA5 interaction
  • ER stress reduces secretion
  • Under the stress, minor amounts of non-secreted forms accumulate in cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
chromaffin granule Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear endoplasmic reticulum lumen The volume enclosed by the membranes of the perinuclear endoplasmic reticulum.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
spherical high-density lipoprotein particle A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT).

3 GO annotations of molecular function

Name Definition
misfolded protein binding Binding to a misfolded protein.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
unfolded protein binding Binding to an unfolded protein.

16 GO annotations of biological process

Name Definition
chaperone-mediated protein folding The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.
immune complex clearance A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution.
intrinsic apoptotic signaling pathway The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
negative regulation of amyloid fibril formation Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.
negative regulation of protein-containing complex assembly Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of intrinsic apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
positive regulation of receptor-mediated endocytosis Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
positive regulation of ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.
regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation.
response to misfolded protein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P25473 CLU Clusterin Canis lupus familiaris (Dog) (Canis familiaris) PR
Q29482 CLU Clusterin Equus caballus (Horse) PR
P10909 CLU Clusterin Homo sapiens (Human) PR
Q06890 Clu Clusterin Mus musculus (Mouse) PR
10 20 30 40 50 60
MKTLLLLVGL LLTWENGPWV LGDKAISDKE LQEMSTEGSK YVNKEIKNAL KEVKQIKTLI
70 80 90 100 110 120
EQSNEERKSL LSSLEEAKKK KEDALNDTRD TETKLKGSQG LCNETMMALW EECKPCLKQT
130 140 150 160 170 180
CMKFYARVCR SGSGLVGHQL EEFLNQSSPF YFWINGDRID SLMENDRQQS HVMDIMEDSF
190 200 210 220 230 240
NRASNIMDEL FQDRFFNREP FDTQFFSPFG SSHRGSLFFN PKSRFARNIM PFPLFTDLNY
250 260 270 280 290 300
HDMFQPFFDM IHQAQQAMDA HLHRIPYHFP EAGVPENSND RAVCKEIRHN STGCLRMKDQ
310 320 330 340 350 360
CEKCREILSV DCSASNSSQM QLRQELYTSL QMAEKFSKLY DQLLQSYQQK MLNTSSLLKQ
370 380 390 400 410 420
LNEQFSWVSQ LANLTQNDDR YYLQVTTVNS HGSDPSVPSG LTKVVVKLFD SYPITLIIPQ
430 440
EVSDPKFMET VAEEALQQYR QRSREE