Q29548

PR
Gene name
HEXB
Protein name
Beta-hexosaminidase subunit beta
Names
65 kDa epididymal boar protein, Beta-N-acetylhexosaminidase subunit beta, Hexosaminidase subunit B, N-acetyl-beta-glucosaminidase subunit beta
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:396958
EC number
3.2.1.52: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-143 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q29548

Entry ID Method Resolution Chain Position Source
AF-Q29548-F1 Predicted AlphaFoldDB

No variants for Q29548

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q29548

No associated diseases with Q29548

3 regional properties for Q29548

Type Name Position InterPro Accession
domain Porphobilinogen deaminase, N-terminal 14 - 229 IPR022417
domain Porphobilinogen deaminase, C-terminal 242 - 316 IPR022418
binding_site Porphobilinogen deaminase, dipyrromethane cofactor binding site 247 - 263 IPR022419

Functions

Description
EC Number 3.2.1.52 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Lysosome
  • Cytoplasmic vesicle, secretory vesicle, Cortical granule
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cortical granule A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
beta-N-acetylhexosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
N-acetyl-beta-D-galactosaminidase activity Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-

4 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
ganglioside catabolic process The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues.
glycosaminoglycan metabolic process The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.
single fertilization The union of male and female gametes to form a zygote.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P49614 HEXB Beta-hexosaminidase subunit beta Felis catus (Cat) (Felis silvestris catus) PR
10 20 30 40 50 60
MEVLPGLLRL LAALVVAERW ARDTSGAESL GLWPLPFAVD ISPRSLHLSP NNFFFGHSPT
70 80 90 100 110 120
SKAGSSCEIL QEAFRRYYDF IFGFYKWHQG SYQLCFGTEL QQLQVHVESE CDTFPSISSN
130 140 150 160 170 180
ESYVLHVKGP EALLRANTVW GALRGLETFS QLIYQDSYGT FTVNESEIID FPRFPHRGIL
190 200 210 220 230 240
IDTGRHFLSV KTIFKTLDAM AFNKFNVLHW HIVDDQSFPY QSINFGVLSS KGSYSLSHVY
250 260 270 280 290 300
TPNDVRMVIE YARIRGIRVM PEFDTPGHSR SWGKGQKDLL TPCYRKQVLS GTFGPINPIL
310 320 330 340 350 360
NTTYNFLSKF FKEISTVFPD EFIHIGGDEV DFDCWASNSE ILQFMQEKGF SQISLNSNLC
370 380 390 400 410 420
TVFKISNMIS AMKKRPIVWQ EAFDGRDKFM PGTVVQVWKI EDYKWEQSLI TKAGFPVILS
430 440 450 460 470 480
APWYLDLISY GQDWKNYYEV EPQDFPGSDK ERKRVLGGEA CLWGEYVDAT NLTPRLWPRA
490 500 510 520 530
SAVGERLWSH KDVRDIHDAY SRLTIHRCRM VRRGIAAEPL FTGYCNHEHR M