Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P49614

Entry ID Method Resolution Chain Position Source
AF-P49614-F1 Predicted AlphaFoldDB

No variants for P49614

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P49614

1 associated diseases with P49614

Without disease ID

2 regional properties for P49614

Type Name Position InterPro Accession
domain Glycoside hydrolase family 20, catalytic domain 174 - 490 IPR015883
domain Beta-hexosaminidase, eukaryotic type, N-terminal 30 - 152 IPR029019

Functions

Description
EC Number 3.2.1.52 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Lysosome
  • Cytoplasmic vesicle, secretory vesicle, Cortical granule
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cortical granule A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
beta-N-acetylhexosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
N-acetyl-beta-D-galactosaminidase activity Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-

4 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
ganglioside catabolic process The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues.
glycosaminoglycan metabolic process The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.
single fertilization The union of male and female gametes to form a zygote.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q29548 HEXB Beta-hexosaminidase subunit beta Sus scrofa (Pig) PR
10 20 30 40 50 60
MRHRGLGLAA LLALLAAVAP RSSAAAGAAL WPMPLSVKTS PRLLHLSRDN FSIGYGPSST
70 80 90 100 110 120
AGPTCSLLQE AFRRYHEYIF GFDKRQRRPA KPNSAIELQQ LLVTVVLDSE CDLFPNITSD
130 140 150 160 170 180
ESYTLLVKEP VAFLKANRVW GVLRGLETFS QLIYQDSYGT FTVNESDIID SPRFPHRGIL
190 200 210 220 230 240
IDTARHFLPV KSILKTLDAM AFNKFNVLHW HIVDDQSFPY QSVTFPELSN KGSYSLSHVY
250 260 270 280 290 300
TPNDVHTVIE YARLRGIRVI PEFDSPGHTQ SWGKGQKDLL TPCYNEHKQS GTFGPINPIL
310 320 330 340 350 360
NSTYNFLSQF FKEVSMVFPD HFVHLGGDEV EFQCWESNPE IQGFMKQKGF GKDFRRLESF
370 380 390 400 410 420
YLQKLLGIVS TVKKGSIVWQ EVFDDHVKLL PGTIVQVWKN QVYTEELREV TAAGFPVILS
430 440 450 460 470 480
APWYLDWISY GQDWRNYYKV DPLHFDGSQE QKKLVIGGEA CLWGEFVDAT NLTPRLWPRA
490 500 510 520 530
SAVGERLWSP EDITSVGNAY NRLTVHRCRM VRRGISAEPL FTGYCDYEYK T