Q29099

PR
Gene name
PTBP1 (PTB)
Protein name
Polypyrimidine tract-binding protein 1
Names
PTB, Heterogeneous nuclear ribonucleoprotein I, hnRNP I
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397461
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q29099

Entry ID Method Resolution Chain Position Source
AF-Q29099-F1 Predicted AlphaFoldDB

No variants for Q29099

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q29099

No associated diseases with Q29099

7 regional properties for Q29099

Type Name Position InterPro Accession
domain RNA recognition motif domain 59 - 143 IPR000504-1
domain RNA recognition motif domain 184 - 260 IPR000504-2
domain RNA recognition motif domain 363 - 437 IPR000504-3
domain RNA recognition motif domain 480 - 555 IPR000504-4
domain PTBP1-like, RNA recognition motif 2 178 - 258 IPR021790
domain PTBP1, RNA recognition motif 1 59 - 139 IPR035000
domain PTBP1, RNA recognition motif 3 364 - 456 IPR035001

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

5 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
negative regulation of mRNA splicing, via spliceosome Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
negative regulation of muscle cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation.
regulation of alternative mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P26599 PTBP1 Polypyrimidine tract-binding protein 1 Homo sapiens (Human) PR
P17225 Ptbp1 Polypyrimidine tract-binding protein 1 Mus musculus (Mouse) PR
Q00438 Ptbp1 Polypyrimidine tract-binding protein 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDGIVPDIAV GTKRGSDELF SACVTNGPFI MSSNSASTAN GNDSKKFKGD NRSAGVPSRV
70 80 90 100 110 120
IHIRKLPSDV TEGEVISLGL PFGKVTNLLM LKGKNQAFIE MNTEEAANTM VNYYTSVTPV
130 140 150 160 170 180
LRGQPIYIQF SNHKELKTDS SPNQARAQAA LQAVNSVQSG NLALAASAAA VDAGMAMAGQ
190 200 210 220 230 240
SPVLRIIVEN LFYPVTLDVL HQIFSKFGTV LKIITFTKNN QFQALLQYAD PVSAQHAKLS
250 260 270 280 290 300
LDGQNIYNAC CTLRIDFSKL TSLNVKYNND KSRDYTRPDL PSGDNQPSLD QTMAAAFGAP
310 320 330 340 350 360
GIMSASPYAG AGFPPTFAIP QAAGLSVPNV HGALAPLAIP SAAAAAAAAG RIAIPGLAGA
370 380 390 400 410 420
GNSVLLVSNL NPERVTPQSL FILFGVYGDV QRVKILFNKK ENALVQMADG SQAQLAMSHL
430 440 450 460 470 480
NGHKLHGKPV RITLSKHQNV QLPREGQEDQ GLTKDYGNSP LHRFKKPGSK NFQNIFPPSA
490 500 510 520 530 540
TLHLSNIPPS ISEEDLKILF SSNGGIVKGF KFFQKDRKMA LIQMGSVEEA IQALIDLHNH
550
DLGENHHLRV SFSKSTI