Q28IE5

PR
Gene name
nit2 (TNeu073c04.1)
Protein name
Omega-amidase NIT2
Names
Nitrilase homolog 2
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:549387
EC number
3.5.1.3: In linear amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

232-276 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28IE5

Entry ID Method Resolution Chain Position Source
AF-Q28IE5-F1 Predicted AlphaFoldDB

No variants for Q28IE5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28IE5

No associated diseases with Q28IE5

2 regional properties for Q28IE5

Type Name Position InterPro Accession
domain Carbon-nitrogen hydrolase 4 - 255 IPR003010
domain Nit1/2, carbon-nitrogen hydrolase domain 5 - 265 IPR045254

Functions

Description
EC Number 3.5.1.3 In linear amides
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
2-oxoglutaramate amidase activity Catalysis of the reaction: 2-oxoglutaramate + H(2)O = 2-oxoglutarate + NH(3).
omega-amidase activity Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3.

3 GO annotations of biological process

Name Definition
asparagine metabolic process The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
oxaloacetate metabolic process The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P49954 NIT3 Omega-amidase NIT3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MAKFRLSLVQ FLVSPVKSEN LNRACKLIKE AAQKGAQIVA LPECFNSPYG TKYFPEYAEK
70 80 90 100 110 120
IPGESTERLS QVAKECGIYL IGGSIPEEDS GKLYNTCAVF GPDGTLLVKH RKIHLFDIDV
130 140 150 160 170 180
PGKIRFQESE TLSPGDSFSV FETPYCKVGV GICYDIRFAE LAQLYSKKGC QLLVYPGAFN
190 200 210 220 230 240
MTTGPAHWEL LQRARALDNQ VYVATASPAR DEKASYVAWG HSTIVSPWGE VIAKAGSEET
250 260 270
VISADIDLEY LAEIREQIPI RRQRRHDLYS VEEKKN