Q28HU2

PR
Gene name
ccz1 (TGas077n04.1)
Protein name
Vacuolar fusion protein CCZ1 homolog
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

219-291 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28HU2

Entry ID Method Resolution Chain Position Source
AF-Q28HU2-F1 Predicted AlphaFoldDB

No variants for Q28HU2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28HU2

No associated diseases with Q28HU2

3 regional properties for Q28HU2

Type Name Position InterPro Accession
domain CCZ1/INTU/HSP4, first Longin domain 15 - 139 IPR043987
domain CCZ1/INTU, second Longin domain 209 - 335 IPR043988
domain CCZ1/INTU/HPS4, third Longin domain 361 - 459 IPR043989

Functions

Description
EC Number
Subcellular Localization
  • Lysosome membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
Mon1-Ccz1 complex A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38273 CCZ1 Vacuolar fusion protein CCZ1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MAYAVQDKRF APSLLSFFIY NPKFGPREGE EEKKILFYHP NEVEKNEKIR NVGLCEAIVQ
70 80 90 100 110 120
FTRTFNPTKP AKSLHTQKNR QFFHEPEEGF WMVMVVKNPL AEKQKEGKTV LEYQEDELLD
130 140 150 160 170 180
KVYSSVLQQC YRMYKLFNGT FSRAMEVGQV ELLKDRLEKF FHRYLQTLHL HSCDLLDVFG
190 200 210 220 230 240
GISFFPLDKM TYLKIQSFIN RIEESLNIVK YTVFLYNDQL IWSGLEQEDM RILYKYLTTT
250 260 270 280 290 300
LFPRYTEPEL AGRDSPIRPE MPGNLQHYGR FLTGPLNLSD PEVKFRFPKI FVNTEDSYEE
310 320 330 340 350 360
LYLIVYKAMS ASVCFMIDAS VQLTVDFCRK LDSLVGPQLT VLASDICEQF NINRRISGSE
370 380 390 400 410 420
KEPQFKFIYF NHMNLAEKST IHLRKTPSMS LTSVQPELMK ILGDINGDFT RVDEDEEIIV
430 440 450 460 470
KAMSDYWVVG KKSDQRELYV ILNQKNSNLI EVNEEIKKLC ATQFSNIFFL D