Q27607
PR
Gene name |
PolG1 |
Protein name |
DNA polymerase subunit gamma-1, mitochondrial |
Names |
3'-5' exodeoxyribonuclease, DNA polymerase gamma subunit 1, Mitochondrial DNA polymerase catalytic subunit, Protein tamas |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG8987 |
EC number |
2.7.7.7: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q27607
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q27607-F1 | Predicted | AlphaFoldDB |
No variants for Q27607
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q27607 | |||||
No associated diseases with Q27607
4 regional properties for Q27607
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA-directed DNA polymerase, family A, palm domain | 786 - 1082 | IPR001098 |
| conserved_site | DNA-directed DNA polymerase, family A, conserved site | 861 - 880 | IPR019760 |
| domain | DNA mitochondrial polymerase, exonuclease domain | 107 - 381 | IPR041336 |
| domain | DNA polymerase gamma, palm domain | 705 - 1107 | IPR047580 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.7 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| gamma DNA polymerase complex | A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrial nucleoid | The region of a mitochondrion to which the DNA is confined. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| 3'-5'-exodeoxyribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
| nucleotide binding | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication proofreading | Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity. |
| DNA-templated DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
| mitochondrial DNA replication | The process in which new strands of DNA are synthesized in the mitochondrion. |
| mitochondrion inheritance | The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton. |
| sperm mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P15801 | MIP1 | DNA polymerase gamma | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQFHLIRKYA | SKVSREHYAS | SSVKIFRRVK | PPQKVNKPKK | PENVENGPTE | YAENLVKVQM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ISRNLHAQLF | PQAPRSISEQ | QVASAKVYKD | ELRRHGVDIE | SSAPVSDVQL | KLPALRGANI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEHFHNIAKE | QVQPYEELLL | PLVQCEQLPK | RPKRWAFHTG | WTAYDPEDGT | ATPVDHPLEK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GLVFDVEVCV | SEGQAPVLAT | AVSTKRWYSW | VSSKLTKHRL | SVEKLEPLDV | DTDSERPHYT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TDELIPLGTT | GPGLVVGHNV | SYDRARLKEQ | YLTEDTGTRF | VDTMSLHMCV | SGVTSYQRAM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKSKKEPAAE | DLGWLEQSSL | NSLVEVHRLY | CGGDTLSKEP | RNIFVEGTLE | QVRQSFQSLT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NYCASDVEAT | HRILRVLYPL | YAERFPHPAS | LAGMLEMGSA | YLPVNSNWER | YIREAQLTYE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DLSIEAKYHL | GRRAEEACSL | LLDDQYRQNL | WLWDEDWSVQ | ELKLKQPPKR | KPLPTVELKD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SGNTPEERRL | QAKFQHLYDQ | QALLPARRPL | LPGYPLWYRK | LCRKPPAKRA | DEILEDDEEP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WSPGASEIST | GMQIAPKLLS | LCWEGYPLHY | EREQGWGFLV | PFRSDSEGVD | RLPMEQLLAH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CPVPEFARLS | ASKAESDMAF | DMLPGQVEQH | LGKREHYKKL | SQKQQRLETQ | YQGSGVWCNK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VLDDCCFFLK | LPHKNGPSFR | VGNPLSKDFL | NKFAENVLSS | GDPSCQAAAR | VIDIARMMSY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| WRNNRDRIMG | QMVVWLDSQQ | LPNEFTGEKC | QPIAYGAICP | QVVACGTLTR | RAMEPTWMTA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SNSRPDRLGS | ELRSMVQAPP | GYRLVGADVD | SQELWIASVL | GDAYACGEHG | ATPLGWMTLS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GSKSNGSDMH | SITAKAVGIS | RDHAKVINYA | RIYGAGQLFA | ETLLRQFNPT | FSASEAKAKA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| MKMFSITKGK | RVYRLREEFH | DELEDRAYSS | YEASRLAIQR | NRTLAEVFHR | PNWQGGTESA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| MFNRLEEIAT | GSQPRTPFLG | GRLSRALEAD | TGPEQEQRFL | PTRINWVVQS | GAVDFLHLML |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VSMRWLMGSH | VRFCLSFHDE | LRYLVKEELS | PKAALAMHIT | NLMTRSFCVS | RIGLQDLPMS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VAFFSSVEVD | TVLRKECTMD | CKTPSNPHGL | RIGYGIQPGQ | SLSVAEAIEK | AGGNDVSQWD |
| WIKKS |