P15801

PR
Gene name
MIP1 (YOR330C)
Protein name
DNA polymerase gamma
Names
Mitochondrial DNA polymerase catalytic subunit
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOR330C
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-146 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P15801

Entry ID Method Resolution Chain Position Source
AF-P15801-F1 Predicted AlphaFoldDB

20 variants for P15801

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-943280 35 T>A No SGRP
s15-943234 50 G>D No SGRP
s15-942875 170 F>L No SGRP
s15-942719 222 I>V No SGRP
s15-942517 289 I>T No SGRP
s15-942314 357 E>K No SGRP
s15-941947 479 K>R No SGRP
s15-941890 498 S>F No SGRP
s15-941764 540 T>M No SGRP
s15-941762 541 H>N No SGRP
s15-941665 573 N>S No SGRP
s15-941543 614 V>I No SGRP
s15-941536 616 S>N No SGRP
s15-941491 631 S>L No SGRP
s15-941402 661 A>T No SGRP
s15-940451 978 S>P No SGRP
s15-940426 986 N>S No SGRP
s15-940411 991 S>N No SGRP
s15-939983 1134 E>K No SGRP
s15-939857 1176 T>A No SGRP

No associated diseases with P15801

4 regional properties for P15801

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family A, palm domain 671 - 920 IPR001098
conserved_site DNA-directed DNA polymerase, family A, conserved site 745 - 764 IPR019760
domain DNA mitochondrial polymerase, exonuclease domain 96 - 362 IPR041336
domain DNA polymerase gamma, palm domain 581 - 960 IPR047580

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
gamma DNA polymerase complex A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

3 GO annotations of biological process

Name Definition
mitochondrial DNA catabolic process The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA.
mitochondrial DNA replication The process in which new strands of DNA are synthesized in the mitochondrion.
mitochondrial genome maintenance The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q27607 PolG1 DNA polymerase subunit gamma-1, mitochondrial Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MTKLMVRSEC MLRMVRRRPL RVQFCARWFS TKKNTAEAPR INPVGIQYLG ESLQRQVFGS
70 80 90 100 110 120
CGGKDEVEQS DKLMELSKKS LKDHGLWGKK TLITDPISFP LPPLQGRSLD EHFQKIGRFN
130 140 150 160 170 180
SEPYKSFCED KFTEMVARPA EWLRKPGWVK YVPGMAPVEV AYPDEELVVF DVETLYNVSD
190 200 210 220 230 240
YPTLATALSS TAWYLWCSPF ICGGDDPAAL IPLNTLNKEQ VIIGHNVAYD RARVLEEYNF
250 260 270 280 290 300
RDSKAFFLDT QSLHIASFGL CSRQRPMFMK NNKKKEAEVE SEVHPEISIE DYDDPWLNVS
310 320 330 340 350 360
ALNSLKDVAK FHCKIDLDKT DRDFFASTDK STIIENFQKL VNYCATDVTA TSQVFDEIFP
370 380 390 400 410 420
VFLKKCPHPV SFAGLKSLSK CILPTKLNDW NDYLNSSESL YQQSKVQIES KIVQIIKDIV
430 440 450 460 470 480
LLKDKPDFYL KDPWLSQLDW TTKPLRLTKK GVPAKCQKLP GFPEWYRQLF PSKDTVEPKI
490 500 510 520 530 540
TIKSRIIPIL FKLSWENSPV IWSKESGWCF NVPHEQVETY KAKNYVLADS VSQEEEEIRT
550 560 570 580 590 600
HNLGLQCTGV LFKVPHPNGP TFNCTNLLTK SYNHFFEKGV LKSESELAHQ ALQINSSGSY
610 620 630 640 650 660
WMSARERIQS QFVVPSCKFP NEFQSLSAKS SLNNEKTNDL AIIIPKIVPM GTITRRAVEN
670 680 690 700 710 720
AWLTASNAKA NRIGSELKTQ VKAPPGYCFV GADVDSEELW IASLVGDSIF NVHGGTAIGW
730 740 750 760 770 780
MCLEGTKNEG TDLHTKTAQI LGCSRNEAKI FNYGRIYGAG AKFASQLLKR FNPSLTDEET
790 800 810 820 830 840
KKIANKLYEN TKGKTKRSKL FKKFWYGGSE SILFNKLESI AEQETPKTPV LGCGITYSLM
850 860 870 880 890 900
KKNLRANSFL PSRINWAIQS SGVDYLHLLC CSMEYIIKKY NLEARLCISI HDEIRFLVSE
910 920 930 940 950 960
KDKYRAAMAL QISNIWTRAM FCQQMGINEL PQNCAFFSQV DIDSVIRKEV NMDCITPSNK
970 980 990 1000 1010 1020
TAIPHGEALD INQLLDKSNS KLGKPNLDID SKVSQYAYNY REPVFEEYNK SYTPEFLKYF
1030 1040 1050 1060 1070 1080
LAMQVQSDKR DVNRLEDEYL RECTSKEYAR DGNTAEYSLL DYIKDVEKGK RTKVRIMGSN
1090 1100 1110 1120 1130 1140
FLDGTKNAKA DQRIRLPVNM PDYPTLHKIA NDSAIPEKQL LENRRKKENR IDDENKKKLT
1150 1160 1170 1180 1190 1200
RKKNTTPMER KYKRVYGGRK AFEAFYECAN KPLDYTLETE KQFFNIPIDG VIDDVLNDKS
1210 1220 1230 1240 1250
NYKKKPSQAR TASSSPIRKT AKAVHSKKLP ARKSSTTNRN LVELERDITI SREY