AiPD: Autoinhibited Protein Database

Gene name	NUBP1
Protein name	Cytosolic Fe-S cluster assembly factor NUBP1
Names	Nucleotide-binding protein 1, NBP 1
Species	Bos taurus (Bovine)
KEGG Pathway	bta:507007
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-76 (Predicted disordered autoinhibitory region) PR

1-76 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q24K00-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs474035288	3	E>*	No	EVA
rs444304086	4	V>G	No	EVA
rs471648504	7	D>A	No	EVA
rs454093433	9	P>L	No	EVA
rs461450502	11	A>S	No	EVA
rs483240865	12	D>Y	No	EVA
rs443748271	14	A>P	No	EVA
rs458990304	14	A>V	No	EVA
rs477473360	15	Q>E	No	EVA
rs466388860	16	A>E	No	EVA
rs447915587	16	A>S	No	EVA
rs478687280	17	G>V	No	EVA
rs448967960	20	A>S	No	EVA
rs467393756	21	S>*	No	EVA
rs471004127	51	K>R	No	EVA
rs441320704	76	A>D	No	EVA
rs442326902	77	H>L	No	EVA
rs475270685	77	H>N	No	EVA
rs482647139	82	D>A	No	EVA
rs449795923	86	Q>K	No	EVA
rs479925161	105	L>V	No	EVA
rs447036938	106	E>*	No	EVA
rs468797627	106	E>G	No	EVA
rs480901238	109	Q>K	No	EVA
rs441194838	110	V>A	No	EVA
rs441194838	110	V>D	No	EVA
rs459553167	111	H>P	No	EVA
rs470401595	117	W>G	No	EVA
rs482523512	117	W>L	No	EVA
rs470401595	117	W>R	No	EVA
rs446213321	118	S>A	No	EVA
rs464890986	118	S>C	No	EVA
rs464890986	118	S>F	No	EVA
rs465724963	120	V>A	No	EVA
rs465724963	120	V>G	No	EVA
rs478967181	152	M>V	No	EVA
rs461251385	165	V>G	No	EVA
rs483136569	180	H>P	No	EVA
rs136440198	188	T>A	No	EVA
rs719165396	189	A>T	No	EVA
rs465327812	194	G>R	No	EVA
rs134140739	196	V>A	No	EVA
rs134140739	196	V>G	No	EVA
rs447810032	200	T>P	No	EVA
rs526298025	224	I>V	No	EVA
rs525696898	236	P>L	No	EVA
rs435608781	241	E>Q	No	EVA
rs475916572	260	K>E	No	EVA
rs439691794	272	R>C	No	EVA
rs451927411	273	I>T	No	EVA
rs720934946	273	I>V	No	EVA
rs432177342	276	S>N	No	EVA
rs432177342	276	S>T	No	EVA
rs453746723	278	D>E	No	EVA
rs465912273	282	S>F	No	EVA
rs436206937	285	V>A	No	EVA
rs454676539	287	A>P	No	EVA
rs454676539	287	A>S	No	EVA
rs452604673	289	D>A	No	EVA
rs443584388	289	D>H	No	EVA
rs471042597	290	S>P	No	EVA
rs109600061	297	R>I	No	EVA
rs715833849	298	S>R	No	EVA
rs468679005	303	I>M	No	EVA
rs446830348	303	I>S	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q24K00

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Cell projection Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, microtubule organizing center Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole	Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis Localized at centrioles and in the nucleus at interphase Colocalizes with nubp-2 at prometaphase Specifically localizes to the axenome of motile cilia as opposed to primary non-motile cilia Localization is independent of NUBP2 and KIFC1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
centriole	A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
cilium	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
4 iron, 4 sulfur cluster binding	Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent FeS chaperone activity	Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis.
iron-sulfur cluster binding	Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
metal ion binding	Binding to a metal ion.

Name	Definition
cell projection organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
cellular iron ion homeostasis	Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
centrosome localization	Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
iron-sulfur cluster assembly	The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
negative regulation of centrosome duplication	Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
protein localization to cell cortex	A process in which a protein is transported to, or maintained in, the cell cortex.
regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q93459	nubp-1	Cytosolic Fe-S cluster assembly factor NUBP1 homolog	Caenorhabditis elegans	PR
Q6P298	nubp1	Cytosolic Fe-S cluster assembly factor nubp1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR