Q22812

PR
Gene name
ceh-39
Protein name
Homeobox protein ceh-39
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_T26C11.7
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

25-117 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q22812

Entry ID Method Resolution Chain Position Source
AF-Q22812-F1 Predicted AlphaFoldDB

No variants for Q22812

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q22812

No associated diseases with Q22812

2 regional properties for Q22812

Type Name Position InterPro Accession
domain Homeobox domain 315 - 379 IPR001356
domain CUT domain 205 - 292 IPR003350

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
  • During mitosis, localizes to metaphase and anaphase chromosomes (PubMed:17720939)
  • In the hermaphrodite gonads, localizes to the nucleus from late pachytene to diakinesis (PubMed:17720939)
  • Localizes to condensed diakinetic chromosomes (PubMed:17720939)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
germ cell nucleus The nucleus of a germ cell, a reproductive cell in multicellular organisms.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

3 GO annotations of biological process

Name Definition
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
primary sex determination The sex determination process that results in the initial specification of sexual status of an individual organism.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P70403 Cux1 Protein CASP Mus musculus (Mouse) PR
10 20 30 40 50 60
MDFSNTYRNY GEVVDFPEDF LSDYVPTVKS EPEPAAIAPS VCEPPISTTR NYGTDFGRAS
70 80 90 100 110 120
SMCGSSSSSS SSSYSSGSSP NYLTENGGDT EEPRFEELVS RKMSFDSENV AQVSNQMDYA
130 140 150 160 170 180
RDTYADSRIP FASIDSNDAL LPYPVNNYVA ALPVPVPAKK SRGRTAPRTP KSLETSKPGR
190 200 210 220 230 240
GVKRPASKEI DAKDLGIGDL SAHMNRQIGD DEELDTQLIA HRILDELKEQ CIPQASLAVK
250 260 270 280 290 300
VLGRSQGTLS DLLRKPKPWG IMKNGRGTFQ RMANWLDLDP VVRRALCFMK KEDVARITGM
310 320 330 340 350 360
AEPTPAKRAR QTTPSDERIR RFTFTQTQLD SLHTVFQQQD RPNREMQQAL SATLKLNRST
370 380 390
VGNFFMNARR RLPKAAPVSQ NLVAEHAIDH NQPGPSHHY