Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q22523
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q22523-F1 | Predicted | AlphaFoldDB |
No variants for Q22523
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q22523 | |||||
No associated diseases with Q22523
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein processing | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P78562 | PHEX | Phosphate-regulating neutral endopeptidase PHEX | Homo sapiens (Human) | PR |
| P42892 | ECE1 | Endothelin-converting enzyme 1 | Homo sapiens (Human) | PR |
| P70669 | Phex | Phosphate-regulating neutral endopeptidase PHEX | Mus musculus (Mouse) | PR |
| P0C1T0 | Mmel1 | Membrane metallo-endopeptidase-like 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKPENGAATW | HPAKRSCLGR | LTTLETLLLV | FLGLLITALL | SVLFLWLWVL | DGYKTFTDGR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PIYPLPFENS | SVAVDRSAKN | HNDVVCTSRE | CVRLAGFLAE | NLNSKINPCE | DFYEFACGNY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GLNKNLPANK | PLRHTISDVQ | SRLNKQVKSM | LQSPISANEK | PWDKVAKGYY | QKCLDEEELE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| STGVEAMRDI | AKRIGGWPTL | EGDKWQEWSH | SWEEQIALVL | NLTGVNAVIL | EMAVTHDPSN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSRSVIELDQ | PKWGAGSRYP | YLSGANDPML | RNYTTLMKMT | AVALGADPAI | AEKEMNEAME |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FELKLVNFSA | DDMVRRDPER | GNNRFELWQL | KSVFPFINFE | KYLKTVFKEL | VALSPNHTVI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VREIDYFVGI | QHVLQSTPKR | VLANYISWRL | VQGFSPFLPP | SAREPFYQFK | ANQTGMFNSP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPDRWEDCVT | LSVIMMDMPV | GRLFVENFFE | KERAMKKMTE | LTSYLKNEFI | KQLHVLDWMD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EITRRRAISK | ANMIEYKSGF | PMVLFNDTWM | EKNWGMIIKP | REYLLHLTIR | VKLVRFTEEL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LRLDQPLDRS | MWFQSPAQVD | AYYAPNNNEM | IFPAGIMQFP | FLTLGVPNYI | TYGMVGAVIG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HEVSHAFDDQ | GGQYDEMGNL | NDWWDAETEE | KFIEKTRCFV | RQYENVHVVE | ADIHLNGQLS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LGENIADNGG | VKTAFNAYKA | WKSNTTGISE | PALPGFQNFT | SQQMFFLAYA | NNWCSLVRPK |
| 730 | 740 | 750 | 760 | ||
| HYIQIILTDV | HAPSKYRAMI | PLQNRPEFAK | AFQCPIGSPM | NPERKCQVW |