P0C1T0

PR
Gene name
Mmel1 (Mell1, Nep2)
Protein name
Membrane metallo-endopeptidase-like 1
Names
NEP2(m), Neprilysin II, NEPII, Neprilysin-2, NEP2, NL2
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
3.4.24.11: Metalloendopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

36-108 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0C1T0

Entry ID Method Resolution Chain Position Source
AF-P0C1T0-F1 Predicted AlphaFoldDB

No variants for P0C1T0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0C1T0

No associated diseases with P0C1T0

2 regional properties for P0C1T0

Type Name Position InterPro Accession
domain Peptidase M13, N-terminal domain 107 - 506 IPR008753
domain Peptidase M13, C-terminal domain 559 - 773 IPR018497

Functions

Description
EC Number 3.4.24.11 Metalloendopeptidases
Subcellular Localization
  • Membrane; Single-pass type II membrane protein
  • Secreted
  • A secreted form produced by proteolytic cleavage also exists
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P42892 ECE1 Endothelin-converting enzyme 1 Homo sapiens (Human) PR
P78562 PHEX Phosphate-regulating neutral endopeptidase PHEX Homo sapiens (Human) PR
P70669 Phex Phosphate-regulating neutral endopeptidase PHEX Mus musculus (Mouse) PR
Q22523 nep-21 Neprilysin-21 Caenorhabditis elegans PR
10 20 30 40 50 60
MGKSESSVGM MERADNCGRR RLGFVECGLL VLLTLLLMGA IVTLGVFYSI GKQLPLLNSL
70 80 90 100 110 120
LHVSRHERTV VKRVLRDSSQ KSDICTTPSC VIAAARILQN MDQSKKPCDN FYQYACGGWL
130 140 150 160 170 180
RHHVIPETNS RYSVFDILRD ELEVILKGVL EDSSVQHRPA VEKAKTLYRS CMNQSVIEKR
190 200 210 220 230 240
DSEPLLNVLD MIGGWPVAMD KWNETMGPKW ELERQLAVLN SQFNRRVLID LFIWNDDQNS
250 260 270 280 290 300
SRHVIYIDQP TLGMPSREYY FKEDSHRVRE AYLQFMTSVA TMLRRDLNLP GETDLVQEEM
310 320 330 340 350 360
AQVLHLETHL ANATVPQEKR HDVTALYHRM GLEELQERFG LKGFNWTLFI QNVLSSVQVE
370 380 390 400 410 420
LLPNEEVVVY GIPYLENLEE IIDVFPAQTL QNYLVWRLVL DRIGSLSQRF KEARVDYRKA
430 440 450 460 470 480
LYGTTMEEVR WRECVSYVNS NMESAVGSLY IKRAFSKDSK SIVSELIEKI RSVFVDNLDE
490 500 510 520 530 540
LNWMDEESKK KAQEKALNIR EQIGYPDYIL EDNNRHLDEE YSSLTFSEDL YFENGLQNLK
550 560 570 580 590 600
NNAQRSLKKL REKVDQNLWI IGAAVVNAFY SPNRNLIVFP AGILQPPFFS KDQPQALNFG
610 620 630 640 650 660
GIGMVIGHEI THGFDDNGRN FDKNGNMLDW WSNFSARHFR QQSQCMIYQY SNFSWELADN
670 680 690 700 710 720
QNVNGFSTLG ENIADNGGVR QAYKAYLQWL AEGGRDQRLP GLNLTYAQLF FINYAQVWCG
730 740 750 760 770
SYRPEFAIQS IKTDVHSPLN AQVLGSLQNL PGFSEAFHCP RGSPMHPMNR CRIW