Q21734

SS
Gene name
rskn-1 (T01H8.1)
Protein name
Putative ribosomal protein S6 kinase alpha-1
Names
EC 2.7.11.1
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

RSK1 plays an important role in many cellular processes. RSK1 is expressed ubiquitously in almost all human tissues, predominantly in kidney, lung and pancreas.The crystal structure of human RSK1 C-terminal kinase domain (CTKD) has been reported. The structure indicates that the autoinhibition of the CTKD is caused by an α-helix occupying the substrate-binding groove.The structure shows autoinhibition of RSK1 CTKD by its αL helix, suggesting that ERK1/2 may activate RSK1 by phosphorylating RSK1 followed by the displacement of αL from its inhibitory position. A similar regulatory mechanism has been observed previously in MAPKAP kinase 2 and murine RSK2 CTKD. The atomic structure of human RSK1 CTKD is of great interest in order to understand the mechanism of RSK activation and for structure-based anticancer-drug development.

Autoinhibitory domains (AIDs)

733-748 (αL helix) SS

Target domain

452-748 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

246-269 (Activation loop from InterPro)

Target domain

104-424 (Protein kinase domain)

Relief mechanism

Assay

593-616 (Activation loop from InterPro)

Target domain

454-712 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q21734

Entry ID Method Resolution Chain Position Source
AF-Q21734-F1 Predicted AlphaFoldDB

No variants for Q21734

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q21734

No associated diseases with Q21734

8 regional properties for Q21734

Type Name Position InterPro Accession
domain Protein kinase domain 104 - 363 IPR000719-1
domain Protein kinase domain 454 - 712 IPR000719-2
domain AGC-kinase, C-terminal 364 - 433 IPR000961
active_site Serine/threonine-protein kinase, active site 225 - 237 IPR008271
binding_site Protein kinase, ATP binding site 110 - 136 IPR017441-1
binding_site Protein kinase, ATP binding site 460 - 487 IPR017441-2
domain Protein kinase, C-terminal 389 - 423 IPR017892
domain Ribosomal S6 kinase, N-terminal catalytic domain 108 - 424 IPR041906

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
protein serine kinase activity Catalysis of the reactions
ribosomal protein S6 kinase activity Catalysis of the reaction

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5F3L1 RPS6KA5 Ribosomal protein S6 kinase alpha-5 Gallus gallus (Chicken) SS
P18652 RPS6KA Ribosomal protein S6 kinase 2 alpha Gallus gallus (Chicken) SS
O75676 RPS6KA4 Ribosomal protein S6 kinase alpha-4 Homo sapiens (Human) SS
Q96S38 RPS6KC1 Ribosomal protein S6 kinase delta-1 Homo sapiens (Human) PR
O75582 RPS6KA5 Ribosomal protein S6 kinase alpha-5 Homo sapiens (Human) SS
P51812 RPS6KA3 Ribosomal protein S6 kinase alpha-3 Homo sapiens (Human) EV
Q15349 RPS6KA2 Ribosomal protein S6 kinase alpha-2 Homo sapiens (Human) SS
Q15418 RPS6KA1 Ribosomal protein S6 kinase alpha-1 Homo sapiens (Human) EV
Q9UK32 RPS6KA6 Ribosomal protein S6 kinase alpha-6 Homo sapiens (Human) SS
Q9Z2B9 Rps6ka4 Ribosomal protein S6 kinase alpha-4 Mus musculus (Mouse) SS
Q8C050 Rps6ka5 Ribosomal protein S6 kinase alpha-5 Mus musculus (Mouse) PR
Q8BLK9 Rps6kc1 Ribosomal protein S6 kinase delta-1 Mus musculus (Mouse) PR
P18653 Rps6ka1 Ribosomal protein S6 kinase alpha-1 Mus musculus (Mouse) SS
P18654 Rps6ka3 Ribosomal protein S6 kinase alpha-3 Mus musculus (Mouse) SS
Q9WUT3 Rps6ka2 Ribosomal protein S6 kinase alpha-2 Mus musculus (Mouse) SS
Q63531 Rps6ka1 Ribosomal protein S6 kinase alpha-1 Rattus norvegicus (Rat) SS
Q18846 rskn-2 Putative ribosomal protein S6 kinase alpha-2 Caenorhabditis elegans PR
10 20 30 40 50 60
MGLQRGMPLA QLGEPFGITP SSIENVSPGI DQCKDHRMDV SMRSDPTDCS SDTTNTFHSS
70 80 90 100 110 120
IHIIQPPPNN GFRLMNWKTD SSSETEIDIG DVRKCGEKAD PRQFELLKVL GQGSFGKVFL
130 140 150 160 170 180
VRKVRGRDSG HVYAMKVLKK ATLKVRDRQR TKLERNILAH ISHPFIVKLH YAFQTEGKLY
190 200 210 220 230 240
LILDFLRGGD LFTRLSKEVM FTEDDVKFYL AELTLALEHL HSLGIVYRDL KPENILLDAD
250 260 270 280 290 300
GHIKVTDFGL SKEAIDSEKK TYSFCGTVEY MAPEVINRRG HSMAADFWSL GVLMFEMLTG
310 320 330 340 350 360
HLPFQGRDRN DTMTQILKAK LSMPHFLTQE AQSLLRALFK RNSQNRLGAG PDGVEEIKRH
370 380 390 400 410 420
AFFAKIDFVK LLNKEIDPPF KPALSTVDST SYFDPEFTKR TPKDSPALPA SANGHEIFRG
430 440 450 460 470 480
FSFVSNAVME ERKLIAKSVR SVPTAKTNPF TDDYEILEKI GNGAHSVVHK CQMKATRRKY
490 500 510 520 530 540
AVKIVKKAVF DATEEVDILL RHSHHQFVVK LFDVYEDETA IYMIEELCEG GELLDKLVNK
550 560 570 580 590 600
KSLGSEKEVA AIMANLLNAV QYLHSQQVAH RDLTAANILF ALKDGDPSSL RIVDFGFAKQ
610 620 630 640 650 660
SRAENGMLMT PCYTAQFVAP EVLRKQGYDR SCDVWSLGVL LHTMLTGCTP FAMGPNDTPD
670 680 690 700 710 720
QILQRVGDGK ISMTHPVWDT ISDEAKDLVR KMLDVDPNRR VTAKQALQHK WIGQKEALPD
730 740 750 760 770 780
RPIQSEQVGE LDMQNVKVAL EQTYKAIASA PSVQLRPVGS SALAKRRMKE ILYANYTKNV
SANA