P18652

SS
Gene name
RPS6KA (RSK)
Protein name
Ribosomal protein S6 kinase 2 alpha
Names
EC 2.7.11.1 , MAP kinase-activated protein kinase 1 , MAPK-activated protein kinase 1 , MAPKAP kinase 1 , MAPKAPK-1 , Ribosomal protein S6 kinase II alpha , S6KII-alpha , p90-RSK
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:386579
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

RSK1 plays an important role in many cellular processes. RSK1 is expressed ubiquitously in almost all human tissues, predominantly in kidney, lung and pancreas.The crystal structure of human RSK1 C-terminal kinase domain (CTKD) has been reported. The structure indicates that the autoinhibition of the CTKD is caused by an α-helix occupying the substrate-binding groove.The structure shows autoinhibition of RSK1 CTKD by its αL helix, suggesting that ERK1/2 may activate RSK1 by phosphorylating RSK1 followed by the displacement of αL from its inhibitory position. A similar regulatory mechanism has been observed previously in MAPKAP kinase 2 and murine RSK2 CTKD. The atomic structure of human RSK1 CTKD is of great interest in order to understand the mechanism of RSK activation and for structure-based anticancer-drug development.

Autoinhibitory domains (AIDs)

708-723 (αL helix) SS

Target domain

433-723 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

222-245 (Activation loop from InterPro)

Target domain

80-400 (Protein kinase domain)

Relief mechanism

Assay

573-596 (Activation loop from InterPro)

Target domain

435-692 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P18652

Entry ID Method Resolution Chain Position Source
AF-P18652-F1 Predicted AlphaFoldDB

No variants for P18652

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P18652

No associated diseases with P18652

9 regional properties for P18652

Type Name Position InterPro Accession
domain Protein kinase domain 80 - 339 IPR000719-1
domain Protein kinase domain 435 - 692 IPR000719-2
domain AGC-kinase, C-terminal 340 - 409 IPR000961
active_site Serine/threonine-protein kinase, active site 201 - 213 IPR008271-1
active_site Serine/threonine-protein kinase, active site 548 - 560 IPR008271-2
binding_site Protein kinase, ATP binding site 86 - 112 IPR017441-1
binding_site Protein kinase, ATP binding site 441 - 464 IPR017441-2
domain Protein kinase, C-terminal 363 - 399 IPR017892
domain Ribosomal S6 kinase, N-terminal catalytic domain 84 - 400 IPR041906

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
protein serine kinase activity Catalysis of the reactions
ribosomal protein S6 kinase activity Catalysis of the reaction

3 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5F3L1 RPS6KA5 Ribosomal protein S6 kinase alpha-5 Gallus gallus (Chicken) SS
Q9UK32 RPS6KA6 Ribosomal protein S6 kinase alpha-6 Homo sapiens (Human) SS
O75676 RPS6KA4 Ribosomal protein S6 kinase alpha-4 Homo sapiens (Human) SS
Q96S38 RPS6KC1 Ribosomal protein S6 kinase delta-1 Homo sapiens (Human) PR
P51812 RPS6KA3 Ribosomal protein S6 kinase alpha-3 Homo sapiens (Human) EV
Q15349 RPS6KA2 Ribosomal protein S6 kinase alpha-2 Homo sapiens (Human) SS
O75582 RPS6KA5 Ribosomal protein S6 kinase alpha-5 Homo sapiens (Human) SS
Q15418 RPS6KA1 Ribosomal protein S6 kinase alpha-1 Homo sapiens (Human) EV
Q9WUT3 Rps6ka2 Ribosomal protein S6 kinase alpha-2 Mus musculus (Mouse) SS
Q9Z2B9 Rps6ka4 Ribosomal protein S6 kinase alpha-4 Mus musculus (Mouse) SS
P18654 Rps6ka3 Ribosomal protein S6 kinase alpha-3 Mus musculus (Mouse) SS
Q8C050 Rps6ka5 Ribosomal protein S6 kinase alpha-5 Mus musculus (Mouse) PR
Q8BLK9 Rps6kc1 Ribosomal protein S6 kinase delta-1 Mus musculus (Mouse) PR
P18653 Rps6ka1 Ribosomal protein S6 kinase alpha-1 Mus musculus (Mouse) SS
Q63531 Rps6ka1 Ribosomal protein S6 kinase alpha-1 Rattus norvegicus (Rat) SS
Q18846 rskn-2 Putative ribosomal protein S6 kinase alpha-2 Caenorhabditis elegans PR
Q21734 rskn-1 Putative ribosomal protein S6 kinase alpha-1 Caenorhabditis elegans SS
10 20 30 40 50 60
MPLAQLAEPW PNMELVQLDT ENGQAAPEEG GNPPCKAKSD ITWVEKDLVD STDKGEGVVK
70 80 90 100 110 120
EINITHHVKE GSEKADPSQF ELLKVLGQGS FGKVFLVRKI TPPDSNHLYA MKVLKKATLK
130 140 150 160 170 180
VRDRVRTKIE RDILADVNHP FVVKLHYAFQ TEGKLYLILD FLRGGDLFTR LSKEVMFTEE
190 200 210 220 230 240
DVKFYLAELA LGLDHLHSLG IIYRDLKPEN ILLDEEGHIK LTDFGLSKEA IDHEKKAYSF
250 260 270 280 290 300
CGTVEYMAPE VVNRQGHSHS ADWWSYGVLM FEMLTGSLPF QGKDRKETMT LILKAKLGMP
310 320 330 340 350 360
QFLSAEAQSL LRALFKRNPA NRLGSGPDGA EEIKRHPFYS TIDWNKLYRR EIKPPFKPAV
370 380 390 400 410 420
GQPDDTFYFD TEFTSRTPKD SPGIPPSAGA HQLFRGFSFV ATGLMEDSKV KPAQPPLHSV
430 440 450 460 470 480
VQQLHGKNIQ FSDGYVVKEA IGVGSYSVCK RCIHKTTNME YAVKVIDKSK RDPSEEIEIL
490 500 510 520 530 540
LRYGQHPNII TLKDVYDDGK YVYLVTELMR GGELLDKILR QKFFSEREAS SVLHTICKTV
550 560 570 580 590 600
EYLHSQGVVH RDLKPSNILY VDESGNPESI RICDFGFAKQ LRAENGLLMT PCYTANFVAP
610 620 630 640 650 660
EVLKRQGYDE GCDIWSLGVL LYTMLAGCTP FANGPSDTPE EILTRIGGGK FSVNGGNWDT
670 680 690 700 710 720
ISDVAKDLVS KMLHVDPHQR LTAKQVLQHP WITQKDSLPQ SQLNYQDVQL VKGAMAATYS
730 740 750
ALNSSKPSPQ LKPIESSILA QRRVKKLPST TL