Q20123

PR
Gene name
epg-4
Protein name
Ectopic P granules protein 4
Names
Species
Caenorhabditis elegans
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q20123

Entry ID Method Resolution Chain Position Source
AF-Q20123-F1 Predicted AlphaFoldDB

No variants for Q20123

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q20123

No associated diseases with Q20123

No regional properties for Q20123

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q20123

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane ; Multi-pass membrane protein
  • Forms a reticular pattern throughout the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
macroautophagy The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
negative regulation of autophagosome assembly Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O14681 EI24 Etoposide-induced protein 2.4 homolog Homo sapiens (Human) PR
Q61070 Ei24 Etoposide-induced protein 2.4 Mus musculus (Mouse) PR
Q4KM77 Ei24 Etoposide-induced protein 2.4 homolog Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MVKFQIIARD FYHGFIDSFK GITFVRRIRE EEAKEVKVEP PKPVERTVLM MRREKQGIFK
70 80 90 100 110 120
RPPEPPKKKD SFLKKLWQIY AMNIGFLVLW QVCILILGLF FSFFDRTDLG HNIGYILIIP
130 140 150 160 170 180
IFFASRIIQA LWFSDISGAC MRALKLPPPP VVPFSSMLAG TLISALHQIF FLIQGMLSQY
190 200 210 220 230 240
LPIPLITPVI VYLHMALLNS MYCFDYFFDG YNLSFLRRKD IFESHWPYFL GFGTPLALAC
250 260 270 280 290 300
SISSNMFVNS VIFALLFPFF IITSYPANWN RKYEEEIPKI AFCRISYMFT ELVGKFVKSI
310
TPTNNPTAAR NNAQN