Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q19954
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q19954-F1 | Predicted | AlphaFoldDB |
No variants for Q19954
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q19954 | |||||
No associated diseases with Q19954
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| HOPS complex | A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cellular response to starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. |
| endosomal vesicle fusion | The homotypic fusion of endocytic vesicles to form or add to an early endosome. |
| macroautophagy | The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| protein targeting to vacuole | The process of directing proteins towards the vacuole, usually using signals contained within the protein. |
| vacuolar protein processing | Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes. |
| vacuolar transport | The directed movement of substances into, out of or within a vacuole. |
| vacuole fusion, non-autophagic | The fusion of two vacuole membranes to form a single vacuole. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38959 | VPS41 | Vacuolar protein sorting-associated protein 41 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDETHENEAS | DSFDPVFENS | YHDDVTFNTE | DDDEPPLEPR | FKYERLKGEE | TLPFMKTATF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TSIDLHDKFI | AIGTATGLIY | ILDHHGYGNF | DSVPPLKPHR | CAVSKVKFDE | TGSYVLSCAN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DSKIVVSGVG | NDKLCCTINI | QVMPKSIYFS | PDFIRQQSGH | CFIMGERNLV | LYEKRMFQYK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ASSLYSGSER | DGFIHCCSWN | ENLIAFTNDT | GTRVYERGAE | RIITSVQPSH | DVDRVRSSRS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PPKHTWMPEN | NLVIGWADTV | TILKIRDDDG | VKKGEVHHIF | HVSMFICGIS | YIPESGIDNM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELFLVGLQLE | GEDFDDCASV | ISTVTTLTAL | ESSACTILKT | SVIRPLGLKE | FELQSEDMIE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SVKLSNHTLP | YMIHGLGIPY | LATYFILTTK | HIIMAVPYGP | EDGIRWRLKY | KLYDEALDMA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KHNADLLSKT | DLSPKKVGRM | IIEGYLTGKR | ARAAASRLPL | ICGECKEEWE | WAVNQFEEVK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LCTLLAEVLP | DGTPTLDPEC | YQKVLIACLF | NNVKQFRKLV | QTWSPDLYMT | SFIIDRTQWR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IQQISKSGNL | ADVDETERVL | MDALAHLYLY | ERKYESALKI | LMSCQDFQIF | NVIDKHQLFD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LVKDQITELM | NINSERALRL | LLDNADSVEP | SFVMEKIGRQ | PKLQLAYLTK | LMSRNEGTEF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ADKAVQLYAE | YDQKKLLPFL | RKNANYNVNK | ARKLCSDKGY | IEETIYLLAK | SGNHYDAVKM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MVREYRNMEK | VIDYCKDQND | PDLWIHLLGV | VAEFPAHFSQ | LIIEASNCLD | PLLIMDKLPD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DSDIPNLSEA | LDKLLVDYTN | HAELQQCCYD | STLNDLNVLT | QGLISAADES | VSVNIVSRCS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LCAQIIINSN | QETTKKFSDI | KVFKCGHIFH | LACSTSEMER | RQSIEEGLCI | ACSDQIELIN |
| V |