Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q15170
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q15170-F1 | Predicted | AlphaFoldDB |
77 variants for Q15170
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| VAR_087930 | 87 | Q>del | NEDGFAX [UniProt] | Yes | UniProt |
| VAR_087931 | 90 | C>Y | NEDGFAX [UniProt] | Yes | UniProt |
|
CA414096188 rs1258382686 VAR_087932 |
116 | D>N | NEDGFAX; unknown pathological significance [UniProt] | Yes |
ClinGen TOPMed gnomAD UniProt |
| VAR_087933 | 149 | W>del | NEDGFAX [UniProt] | Yes | UniProt |
| TCGA novel | 2 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs762018669 CA10478383 |
3 | K>Q | No |
ClinGen ExAC |
|
| TCGA novel | 4 | P>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
VAR_057270 CA10478384 rs34421776 |
5 | R>C | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| TCGA novel | 5 | R>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1246500117 CA414095409 |
7 | E>A | No |
ClinGen gnomAD |
|
|
rs374247678 CA10478386 |
12 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA333989204 rs374247678 |
12 | P>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 15 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs761252179 CA10478387 |
17 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs766835211 CA10478388 |
19 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1456424885 CA414095527 |
19 | D>N | No |
ClinGen gnomAD |
|
|
CA414095526 rs1456424885 |
19 | D>Y | No |
ClinGen gnomAD |
|
|
rs866226033 CA333989205 |
24 | P>T | No |
ClinGen Ensembl |
|
|
rs763685742 CA10478391 |
28 | S>A | No |
ClinGen ExAC gnomAD |
|
|
rs751181266 CA10478392 |
33 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA10478396 rs759474630 |
35 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA414095659 rs1309143571 |
38 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
CA333989208 rs1033618962 COSM1464554 |
39 | S>L | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs200374529 CA333989207 |
39 | S>P | No |
ClinGen Ensembl |
|
| TCGA novel | 43 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA414095744 rs1394297460 |
50 | P>S | No |
ClinGen TOPMed |
|
|
CA414095751 rs1187653939 |
51 | E>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 52 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs779980584 CA10478398 |
61 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs1603180742 CA414095852 |
66 | E>K | No |
ClinGen Ensembl |
|
|
CA414095860 rs1418662944 |
67 | R>C | No |
ClinGen gnomAD |
|
|
CA414095864 rs1052145 |
67 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
CA333989210 rs1052145 |
67 | R>L | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 68 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 69 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1214910161 CA414095873 |
69 | P>S | No |
ClinGen TOPMed |
|
|
rs774757358 CA414095897 |
72 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774757358 CA10478401 |
72 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748361525 CA10478402 |
73 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1052146 CA333989211 |
81 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1200715058 CA414095963 |
82 | R>L | No |
ClinGen TOPMed |
|
|
CA333989213 rs1030471650 |
84 | P>S | No |
ClinGen TOPMed |
|
|
rs1289182825 CA414095979 |
85 | M>T | No |
ClinGen gnomAD |
|
|
rs1471910741 CA414096023 |
91 | G>E | No |
ClinGen gnomAD |
|
| TCGA novel | 93 | G>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1232592046 CA414096053 |
95 | H>Q | No |
ClinGen TOPMed |
|
|
CA414096047 rs1277688369 |
95 | H>Y | No |
ClinGen TOPMed |
|
|
CA333989216 rs1052148 |
96 | K>N | No |
ClinGen Ensembl |
|
|
CA10478403 rs772337828 |
96 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1052149 CA333989217 |
101 | S>I | No |
ClinGen Ensembl |
|
|
CA333989218 rs750265883 |
105 | R>S | No |
ClinGen Ensembl |
|
|
rs773422658 CA10478404 |
106 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA414096141 rs1281655970 |
108 | R>P | No |
ClinGen gnomAD |
|
|
CA333989219 rs775237143 |
110 | R>H | No |
ClinGen 1000Genomes gnomAD |
|
|
rs775237143 CA414096152 |
110 | R>L | No |
ClinGen 1000Genomes gnomAD |
|
|
rs1262800007 CA414096159 |
111 | P>L | No |
ClinGen gnomAD |
|
|
rs760771251 CA10478405 |
112 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
rs1210785725 CA414096175 |
114 | R>G | No |
ClinGen gnomAD |
|
|
rs1185622805 CA414096192 |
116 | D>G | No |
ClinGen gnomAD |
|
|
rs760687124 CA10478406 |
120 | R>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA10478407 rs777155549 |
121 | N>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA10478408 rs368425759 |
123 | S>R | No |
ClinGen ESP ExAC gnomAD |
|
|
CA414096249 rs1271301185 |
124 | N>S | No |
ClinGen TOPMed |
|
|
rs1324833971 CA414096336 |
135 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA10478409 rs765611494 |
137 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs751269057 CA10478410 |
138 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1171933509 CA414096408 |
140 | V>I | No |
ClinGen TOPMed |
|
|
CA10478412 rs767087571 |
148 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1372168673 CA414096538 |
149 | W>* | No |
ClinGen gnomAD |
|
|
rs1277210962 CA414096529 |
149 | W>R | No |
ClinGen gnomAD |
|
|
CA333989220 rs1052150 |
150 | K>R | No |
ClinGen Ensembl |
|
|
CA414096573 rs370963817 |
153 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs370963817 CA10478413 |
153 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1063678 CA333989221 |
154 | S>G | No |
ClinGen Ensembl |
|
|
rs1052151 CA333989222 |
155 | R>G | No |
ClinGen gnomAD |
|
|
rs1052151 CA414096590 |
155 | R>S | No |
ClinGen gnomAD |
|
| TCGA novel | 156 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
No associated diseases with Q15170
No regional properties for Q15170
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q15170 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| WW domain binding | Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KIJ9 | TCEAL1 | Transcription elongation factor A protein-like 1 | Bos taurus (Bovine) | PR |
| Q921P9 | Tceal1 | Transcription elongation factor A protein-like 1 | Mus musculus (Mouse) | PR |
| Q8R0A5 | Tceal3 | Transcription elongation factor A protein-like 3 | Mus musculus (Mouse) | PR |
| Q5PPP3 | Tceal1 | Transcription elongation factor A protein-like 1 | Rattus norvegicus (Rat) | PR |
| A2D671 | TCEAL1 | Transcription elongation factor A protein-like 1 | Macaca mulatta (Rhesus macaque) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDKPRKENEE | EPQSAPKTDE | ERPPVEHSPE | KQSPEEQSSE | EQSSEEEFFP | EELLPELLPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MLLSEERPPQ | EGLSRKDLFE | GRPPMEQPPC | GVGKHKLEEG | SFKERLARSR | PQFRGDIHGR |
| 130 | 140 | 150 | |||
| NLSNEEMIQA | ADELEEMKRV | RNKLMIMHWK | AKRSRPYPI |