AiPD: Autoinhibited Protein Database

Q14919

Gene name	DRAP1
Protein name	Dr1-associated corepressor
Names	Dr1-associated protein 1, Negative cofactor 2-alpha, NC2-alpha
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10589
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-205 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-205 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q14919

Entry ID	Method	Resolution	Chain	Position	Source
1JFI	X-ray	262 A	A	1-77	PDB
AF-Q14919-F1	Predicted				AlphaFoldDB

172 variants for Q14919

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA381376252 rs1230599132	2	P>L		No	ClinGen gnomAD
TCGA novel	3	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1341197444 CA381376271	4	K>Q		No	ClinGen TOPMed gnomAD
CA381376279 rs1222897599	4	K>R		No	ClinGen gnomAD
CA6112148 rs747634661	10	A>S		No	ClinGen ExAC gnomAD
TCGA novel	12	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	14	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	15	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1394777832 CA381378343	18	K>R		No	ClinGen Ensembl
TCGA novel	20	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765527473 CA6112173	21	M>V		No	ClinGen ExAC gnomAD
CA381378418 rs1303832206	22	Q>*		No	ClinGen TOPMed
CA6112174 rs775993555	23	T>M		No	ClinGen ExAC gnomAD
rs370030690 CA224016933	26	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1277141575 CA381378565	30	V>M		No	ClinGen gnomAD
CA6112179 rs201738884	32	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA381378597 rs1442396393	32	A>T		No	ClinGen gnomAD
CA6112178 rs201738884	32	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1591101379 CA381378633	34	V>G		No	ClinGen Ensembl
rs753828914 CA6112180	35	P>L		No	ClinGen ExAC gnomAD
CA381378666 rs1172273425	37	I>V		No	ClinGen TOPMed
TCGA novel	38	I>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1181745938 CA381378710	39	S>A		No	ClinGen gnomAD
CA224017023 rs1003675475	40	R>Q		No	ClinGen TOPMed gnomAD
rs1435106278 CA381378793	40	R>W		No	ClinGen gnomAD
rs895419376 CA381378826	41	A>E		No	ClinGen TOPMed gnomAD
rs539142750 CA6112199	41	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA224017026 rs895419376	41	A>V		No	ClinGen TOPMed gnomAD
CA381378880 rs1471754549	43	E>D		No	ClinGen TOPMed
CA6112201 rs752391356	44	L>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	45	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6112203 rs777230237	46	L>I		No	ClinGen ExAC TOPMed gnomAD
rs924507193 CA224017042	48	S>L		No	ClinGen TOPMed
rs1457645937 CA381379007	49	L>P		No	ClinGen TOPMed
CA381379110 rs1447630272	52	K>N		No	ClinGen gnomAD
CA6112205 rs756973190	53	A>V		No	ClinGen ExAC gnomAD
rs745436509 CA6112207	55	Q>*		No	ClinGen ExAC gnomAD
rs1161100696 CA381379207	55	Q>H		No	ClinGen TOPMed gnomAD
rs1591101497 CA381379234	56	V>G		No	ClinGen Ensembl
rs1245544184 CA381379384	61	N>K		No	ClinGen TOPMed
rs780642209 CA6112209	65	M>V		No	ClinGen ExAC gnomAD
rs1385799799 CA381379518	66	T>I		No	ClinGen gnomAD
CA6112210 rs143982811	67	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA381379555 rs1342638376	69	H>Y		No	ClinGen TOPMed gnomAD
CA381379808 rs1230992913	71	K>R		No	ClinGen TOPMed gnomAD
CA381379811 rs1230992913	71	K>T		No	ClinGen TOPMed gnomAD
TCGA novel	78	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA224017271 rs761980588	82	F>L		No	ClinGen Ensembl
CA6112244 rs765897732	88	A>S		No	ClinGen ExAC TOPMed gnomAD
CA6112245 rs753337480	89	S>A		No	ClinGen ExAC gnomAD
CA381380356 rs1309140747	91	P>R		No	ClinGen TOPMed
rs1432041576 CA381380351	91	P>S		No	ClinGen gnomAD
rs140904739 CA224017287	93	M>V		No	ClinGen ESP gnomAD
CA6112248 rs779595242	95	G>R		No	ClinGen ExAC gnomAD
rs748470098 CA6112249	95	G>V		No	ClinGen ExAC TOPMed gnomAD
rs778071745 CA6112251	96	D>N		No	ClinGen ExAC TOPMed gnomAD
CA6112252 rs143062944	97	G>R		No	ClinGen ESP ExAC gnomAD
CA381380625 rs1331053839	98	E>K		No	ClinGen TOPMed
CA381380686 rs1462964506	100	N>D		No	ClinGen TOPMed
CA6112256 rs768545872	102	M>I		No	ClinGen ExAC gnomAD
rs141033990 CA6112255	102	M>T		No	ClinGen ESP ExAC gnomAD
CA6112254 rs543738162	102	M>V		No	ClinGen 1000Genomes ExAC gnomAD
CA381380784 rs774294429	103	D>H		No	ClinGen ExAC gnomAD
CA6112257 rs774294429	103	D>N		No	ClinGen ExAC gnomAD
rs761538985 CA6112258	104	G>A		No	ClinGen ExAC TOPMed gnomAD
CA6112260 rs371036532	106	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA6112261 rs760351628	108	A>T		No	ClinGen ExAC gnomAD
rs150283691 CA6112262	109	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1438025090 CA381380901	109	R>P		No	ClinGen TOPMed
CA381381168 rs1212848910	111	G>S		No	ClinGen gnomAD
rs368472384 COSM1739748 CA6112284	112	R>Q	NS [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA6112283 rs759048752	112	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1254200181 CA381381282	115	G>C		No	ClinGen gnomAD
TCGA novel	116	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763532913 CA6112287	117	G>S		No	ClinGen ExAC gnomAD
CA224017377 rs867126309	118	G>D		No	ClinGen gnomAD
rs1159566380 CA381381382	118	G>S		No	ClinGen TOPMed
CA224017379 rs969878412	119	R>G		No	ClinGen TOPMed
rs1373398145 CA381381430	119	R>Q		No	ClinGen gnomAD
CA381381412 COSM1204541 rs969878412	119	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA381381447 rs1591101908	120	K>E		No	ClinGen Ensembl
rs1308282104 CA381381487	121	N>T		No	ClinGen TOPMed gnomAD
rs1351998924 CA381381506	122	G>S		No	ClinGen gnomAD
CA381381561 rs1439528891	123	G>E		No	ClinGen gnomAD
rs973368266 CA224017380	123	G>R		No	ClinGen Ensembl
rs992162385 CA224017382	124	M>T		No	ClinGen TOPMed gnomAD
CA381381686 rs1367675675	126	T>M		No	ClinGen gnomAD
CA381381682 rs1367675675	126	T>R		No	ClinGen gnomAD
CA381381712 rs1278736552	127	K>R		No	ClinGen gnomAD
rs528558933 CA6112290	128	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA381381759 rs1206254669	129	K>E		No	ClinGen gnomAD
CA6112291 rs370429317	130	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA381381792 rs1482220567	130	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs750651508 CA6112292	131	K>N		No	ClinGen ExAC TOPMed gnomAD
rs950426651 CA224017386	134	S>C		No	ClinGen TOPMed
TCGA novel rs749407519 CA6112295	135	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
rs1228881174 CA381382143	138	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6112316 rs529754496	142	D>N		No	ClinGen ExAC TOPMed gnomAD
CA381382524 rs1437763431	143	E>K		No	ClinGen TOPMed
CA224017481 rs781110835	144	S>C		No	ClinGen ExAC TOPMed gnomAD
CA6112317 rs781110835	144	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA381382667 rs769532800	146	D>E		No	ClinGen ExAC TOPMed gnomAD
rs745699388 CA6112318	146	D>N		No	ClinGen ExAC TOPMed gnomAD
COSM358561 CA224017487 rs1018604621	147	T>A	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
CA381382704 rs1473613514	147	T>I		No	ClinGen gnomAD
CA6112320 rs199540648	148	D>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA224017494 rs111381779	149	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6112321 rs111381779	149	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA224017497 rs777795705	151	G>R		No	ClinGen Ensembl
CA6112322 rs138267909	152	E>K		No	ClinGen ESP ExAC gnomAD
CA6112324 rs762216373	154	E>A		No	ClinGen ExAC TOPMed gnomAD
rs762216373 CA381382948	154	E>G		No	ClinGen ExAC TOPMed gnomAD
CA224017503 rs909423551	154	E>K		No	ClinGen TOPMed gnomAD
rs1591102205 CA381383056	157	Q>H		No	ClinGen Ensembl
rs1292826685 CA381383075	158	P>H		No	ClinGen gnomAD
rs773522319 CA381383071	158	P>S		No	ClinGen ExAC gnomAD
CA6112326 rs773522319	158	P>T		No	ClinGen ExAC gnomAD
rs535528544 CA6112327	159	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs923531664 CA224017524	160	P>L		No	ClinGen TOPMed
rs1313682527 CA381383111	160	P>S		No	ClinGen gnomAD
rs1348509305 CA381383124	161	Q>K		No	ClinGen gnomAD
CA6112329 rs754063411	161	Q>R		No	ClinGen ExAC gnomAD
CA381383173 rs1470000923	162	A>T		No	ClinGen TOPMed
CA381383246 rs1380517232	163	S>R		No	ClinGen TOPMed gnomAD
CA381383259 rs1256669222	164	H>D		No	ClinGen gnomAD
rs755293005 CA6112330	165	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1486498200 CA381383300	165	P>S		No	ClinGen gnomAD
rs1133928 CA224017536	166	S>F		No	ClinGen gnomAD
rs1133928 CA381383329	166	S>Y		No	ClinGen gnomAD
rs1338500918 CA381383338	167	A>T		No	ClinGen TOPMed gnomAD
rs10143 CA224017541	168	H>L		No	ClinGen ExAC TOPMed gnomAD
rs10143 CA6112332	168	H>P		No	ClinGen ExAC TOPMed gnomAD
rs924222620 CA224017545	169	F>C		No	ClinGen TOPMed
rs1303469823 CA381383631	171	S>R		No	ClinGen gnomAD
CA381383637 rs1443524049	172	P>A		No	ClinGen TOPMed
CA6112356 rs756191355	173	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA381383666 rs756191355	173	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs751570365	174	T>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs753718615 CA6112358	175	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs201871633 CA6112359	177	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs778647605 CA6112360	178	P>L		No	ClinGen ExAC gnomAD
CA381383801 rs777331540	180	A>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs777331540 COSM930582 CA6112363	180	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs747500157 CA6112364	180	A>V		No	ClinGen ExAC gnomAD
rs1055612 CA224017737	181	S>F		No	ClinGen Ensembl
CA381383900 rs1430597685	183	L>M		No	ClinGen TOPMed gnomAD
rs1430597685 CA381383902	183	L>V		No	ClinGen TOPMed gnomAD
CA6112366 rs200905448	184	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA381383917 rs1591102485	184	P>S		No	ClinGen Ensembl
rs1469950476 CA381383950	185	L>F		No	ClinGen TOPMed gnomAD
rs568931883 CA6112368	186	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA381383997 rs1293575746	187	P>L		No	ClinGen TOPMed
CA6112370 rs763060612	188	A>V		No	ClinGen ExAC TOPMed gnomAD
CA381384032 rs1315549961	189	P>H		No	ClinGen TOPMed
CA6112373 rs368226803	190	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs754813408 CA6112376	192	P>L		No	ClinGen ExAC gnomAD
CA6112378 rs752385950	193	S>L		No	ClinGen ExAC TOPMed gnomAD
CA224017762 COSM1561657 rs143922438	194	A>T	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP NCI-TCGA
CA6112380 rs777241976	196	D>N		No	ClinGen ExAC TOPMed gnomAD
CA6112381 rs144277926	198	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs371695352 CA224017773	199	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA224017769 rs957107181	199	D>N		No	ClinGen Ensembl
CA381384226 rs1249147380	199	D>V		No	ClinGen gnomAD
rs1159505236 CA381384238	200	E>G		No	ClinGen TOPMed
CA6112383 rs781734189	200	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs746162493 CA6112384	201	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1424674528 CA381384246	201	E>K		No	ClinGen gnomAD
CA381384250 rs1424674528	201	E>Q		No	ClinGen gnomAD
CA6112385 rs201827894	202	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs552975920 CA6112387	204	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA381384342 rs1345762640	205	S>P		No	ClinGen gnomAD
CA381384367 rs1198595991	206	S>W		No	ClinGen TOPMed

No associated diseases with Q14919

3 regional properties for Q14919

Type	Name	Position	InterPro Accession
domain	SWIB/MDM2 domain	306 - 383	IPR003121
domain	SWIB domain	307 - 386	IPR019835
domain	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D 2, SWIB domain	307 - 386	IPR030090

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
negative cofactor 2 complex	A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase II transcription regulator complex	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.

8 GO annotations of molecular function

Name	Definition
core promoter sequence-specific DNA binding	Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
identical protein binding	Binding to an identical protein or proteins.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
RNA polymerase II general transcription initiation factor activity	A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.
RNA polymerase II general transcription initiation factor binding	Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
TBP-class protein binding	Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
transcription coactivator activity	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

4 GO annotations of biological process

Name	Definition
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P40096	BUR6	Negative cofactor 2 complex subunit alpha	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q2YDP3	DRAP1	Dr1-associated corepressor	Bos taurus (Bovine)	PR
Q9D6N5	Drap1	Dr1-associated corepressor	Mus musculus (Mouse)	PR
A0JPP1	Drap1	Dr1-associated corepressor	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MPSKKKKYNA	RFPPARIKKI	MQTDEEIGKV	AAAVPVIISR	ALELFLESLL	KKACQVTQSR
70	80	90	100	110	120
NAKTMTTSHL	KQCIELEQQF	DFLKDLVASV	PDMQGDGEDN	HMDGDKGARR	GRKPGSGGRK
130	140	150	160	170	180
NGGMGTKSKD	KKLSGTDSEQ	EDESEDTDTD	GEEETSQPPP	QASHPSAHFQ	SPPTPFLPFA
190	200
STLPLPPAPP	GPSAPDEEDE	EDYDS