Q148G5

PR
Gene name
PRODH
Protein name
Proline dehydrogenase 1, mitochondrial
Names
Proline oxidase
Species
Bos taurus (Bovine)
KEGG Pathway
bta:505094
EC number
1.5.5.2: With a quinone or similar compound as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q148G5

Entry ID Method Resolution Chain Position Source
AF-Q148G5-F1 Predicted AlphaFoldDB

No variants for Q148G5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q148G5

No associated diseases with Q148G5

1 regional properties for Q148G5

Type Name Position InterPro Accession
domain Proline dehydrogenase domain 130 - 568 IPR002872

Functions

Description
EC Number 1.5.5.2 With a quinone or similar compound as acceptor
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
proline dehydrogenase activity Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.

1 GO annotations of biological process

Name Definition
proline catabolic process to glutamate The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O45228 prdh-1 Proline dehydrogenase 1, mitochondrial Caenorhabditis elegans PR
10 20 30 40 50 60
MGLRRTSWMH FSALCRRAPL STAPAAREQP AAGPGAEPVC GPAETARPPV PAVDFGNTQE
70 80 90 100 110 120
AYRSRRSWEL ARSLLVLSLC ASPALLARHE QLLHLARKLL GQRLFNTLMK MTFYGQFVAG
130 140 150 160 170 180
EDQESIRPLI QHNRAFGVGS ILDYGVEEDL TPEEAERTEM ESCSSALERD GCGVSKREKQ
190 200 210 220 230 240
FQAHRAFGDR RDGVTSARTY FYASEAKCDS HMETFLHCIE ASGGASEDGF SAIKLTALGR
250 260 270 280 290 300
PQFLLQFSDM LTKWRRFFHH VAAEQGKAGL AAVDTKLEVA ALQESVVKMG IASRAEIEDW
310 320 330 340 350 360
FTAETLGVSG TLDLLDWCSL IDSRTELSRH LVVPNMQTGR LEPLLSQFTE EEERQMTRML
370 380 390 400 410 420
QRMDVLAKKA NQVGVRLMVD AEQTYFQPAI SRLTLEMQRR FNVERPLIFN TFQCYLRDAY
430 440 450 460 470 480
DNVILDVELA RREGWCFGAK LVRGAYMAQV GYEDPINPTY EATSAVYHRC LDYVLEELKH
490 500 510 520 530 540
NARAAVMVAS HNEDTVRFTL RRMEELGLHP ADRQVYFGQL LGMCDHISFP LGQAGFPVYK
550 560 570 580 590
YVPYGPVMEV LPYLSRRALE NSGVMKGAQR ERQLLWQELK RRLCTRSLFH QPA