O45228

PR
Gene name
prdh-1
Protein name
Proline dehydrogenase 1, mitochondrial
Names
Proline oxidase
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_B0513.5
EC number
1.5.5.2: With a quinone or similar compound as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-94 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O45228

Entry ID Method Resolution Chain Position Source
AF-O45228-F1 Predicted AlphaFoldDB

No variants for O45228

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O45228

No associated diseases with O45228

1 regional properties for O45228

Type Name Position InterPro Accession
domain Proline dehydrogenase domain 134 - 589 IPR002872

Functions

Description
EC Number 1.5.5.2 With a quinone or similar compound as acceptor
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
proline dehydrogenase activity Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.

1 GO annotations of biological process

Name Definition
proline catabolic process to glutamate The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q148G5 PRODH Proline dehydrogenase 1, mitochondrial Bos taurus (Bovine) PR
10 20 30 40 50 60
MQAALIGLNF PLQRRFLSGV LTTTSSAKRC YSGDTGKPYD CTSAEHKKEL EECYNRLDLS
70 80 90 100 110 120
FENTKEAFKS KSNTELVRAL VVLRLCGIQT LVNQNQIILN TMRRVLGKNL FKKTLKNTFF
130 140 150 160 170 180
GHFVAGETEE EVRHVVEKLR NYGVKSILDY SVEADITSQE ATDKTVKGTS VATVKPAAMT
190 200 210 220 230 240
PVVDAKTLET TRERYTVHEE FGDRRQGVSS ARTYFYEGEE QCDKNRDIFK DSINAVASAT
250 260 270 280 290 300
KNEGFVAVKI TALGRPQLLL KLSEAIVQTQ NFFKALTGGM SLQEGRLTSQ EFYKRLGELG
310 320 330 340 350 360
VKTDTESVKK FFDEVDFDSD GIVDLHGWNH ILDDHVKLGQ LFQVLNIKTG SLEPLIQNLS
370 380 390 400 410 420
NEEEQEFRNM VRRTLDVAEY AIEKGVRIMV DAEQTYLQPA ISKITIEMMK KYNKGRGNIF
430 440 450 460 470 480
NTYQAYLKGT LQNMEADMQV ARREGWHFGA KLVRGAYMEQ ERARAKAIGY EDPINDNFEA
490 500 510 520 530 540
TSKMYESCLT RIADEVHRRG KTNVSVMVAS HNEDTVRFAL NLMKEKCISP SERVMCMAQL
550 560 570 580 590 600
YGMCDQVSFS LGQAGFSVYK YLPYGPVEEV LPYLSRRALE NGSVLKKANK ERDLLWKELK
610
RRISSGEFKA RSSSSS