AiPD: Autoinhibited Protein Database

Q13601

Gene name	KRR1 (HRB2)
Protein name	KRR1 small subunit processome component homolog
Names	HIV-1 Rev-binding protein 2, KRR-R motif-containing protein 1, Rev-interacting protein 1, Rip-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11103
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-55 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q13601

Entry ID	Method	Resolution	Chain	Position	Source
7MQ8	EM	360 A	NY	1-381	PDB
7MQ9	EM	387 A	NY	1-381	PDB
AF-Q13601-F1	Predicted				AlphaFoldDB

297 variants for Q13601

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs763042419 CA6693313	2	A>P		No	ClinGen ExAC TOPMed gnomAD
CA385814439 rs763042419	2	A>S		No	ClinGen ExAC TOPMed gnomAD
rs980660589 CA239316695	2	A>V		No	ClinGen TOPMed
rs769934831 CA6693311	3	S>F		No	ClinGen ExAC gnomAD
CA6693312 rs773362154	3	S>P		No	ClinGen ExAC gnomAD
rs980996973 CA385814407	4	P>A		No	ClinGen TOPMed gnomAD
CA6693310 rs748668238	4	P>L		No	ClinGen ExAC gnomAD
rs980996973 CA239316685	4	P>S		No	ClinGen TOPMed gnomAD
CA385814387 COSM1299866 rs1309560214	5	S>L	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1374062751 CA385814378	6	L>P		No	ClinGen TOPMed gnomAD
rs1374062751 CA385814379	6	L>Q		No	ClinGen TOPMed gnomAD
rs769201553 CA6693308	7	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs780242758 CA6693306	8	R>L		No	ClinGen ExAC gnomAD
CA6693307 rs780242758	8	R>Q		No	ClinGen ExAC gnomAD
rs758092492 CA6693305	9	P>L		No	ClinGen ExAC gnomAD
rs749988147 CA6693304	10	E>G		No	ClinGen ExAC TOPMed
rs1165441053 CA385814328	10	E>Q		No	ClinGen gnomAD
CA6693302 rs756758474	11	K>E		No	ClinGen ExAC TOPMed gnomAD
CA6693301 rs200760522	11	K>N		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	12	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764001652 CA6693300	12	G>S		No	ClinGen ExAC TOPMed gnomAD
rs140534370 CA6693298	13	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs140534370 CA385814277	13	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA6693297 rs767163062	13	A>V		No	ClinGen ExAC gnomAD
rs1234203493 CA385814253	14	G>R		No	ClinGen TOPMed
CA6693296 rs763247888	15	K>E		No	ClinGen ExAC gnomAD
CA385814209 rs1207936006	16	S>G		No	ClinGen gnomAD
CA385814193 rs1355412947	16	S>R		No	ClinGen gnomAD
CA239316624 rs867762931	20	N>T		No	ClinGen Ensembl
CA6693295 rs773238416	20	N>Y		No	ClinGen ExAC gnomAD
rs1241930793 CA385814114	21	Q>K		No	ClinGen gnomAD
CA6693294 rs770064660	23	P>L		No	ClinGen ExAC gnomAD
rs777326564 CA6693292	25	P>A		No	ClinGen ExAC
CA385812768 rs1374324789	32	E>K		No	ClinGen TOPMed
rs762022873 CA6693270	33	L>P		No	ClinGen ExAC gnomAD
CA385812738 TCGA novel rs1594070512	34	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA6693268 COSM1364232 rs375387200	35	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1262158200 CA385812723	35	T>S		No	ClinGen gnomAD
CA6693266 rs775857215	36	V>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	36	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1218125523 CA385812694	37	P>L		No	ClinGen gnomAD
TCGA novel	38	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs998489326 CA239314373	39	G>V		No	ClinGen TOPMed gnomAD
CA385812599 rs776489825	43	P>L		No	ClinGen TOPMed gnomAD
CA239314359 rs776489825	43	P>R		No	ClinGen TOPMed gnomAD
CA6693264 rs17115182	43	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6693262 rs770604908 COSM3739880	44	A>S	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs759423516 CA239314346	45	F>*		No	ClinGen gnomAD
rs748887670 CA6693261	47	K>E		No	ClinGen ExAC gnomAD
rs1042725976 CA239314337	50	N>S		No	ClinGen TOPMed
CA239314325 rs949822941	51	P>H		No	ClinGen TOPMed
CA385812471 rs949822941	51	P>R		No	ClinGen TOPMed
CA239314312 rs947055632	53	G>E		No	ClinGen TOPMed gnomAD
CA6693260 rs777274509	53	G>R		No	ClinGen ExAC gnomAD
CA239314307 rs915557862	55	L>S		No	ClinGen Ensembl
CA385812272 rs1418588553	59	S>G		No	ClinGen gnomAD
TCGA novel	60	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385812238 rs1182219021	60	F>Y		No	ClinGen gnomAD
rs549769836 CA6693257	61	A>S		No	ClinGen ExAC TOPMed gnomAD
CA239314280 rs549769836	61	A>T	Variant assessed as Somatic; 9.252e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA385812157 rs766235946	63	L>S		No	ClinGen ExAC TOPMed gnomAD
CA6693254 rs766235946	63	L>W		No	ClinGen ExAC TOPMed gnomAD
CA239314266 rs930571667	68	R>G		No	ClinGen TOPMed gnomAD
CA239314260 rs17851432	69	E>G		No	ClinGen Ensembl
CA6693253 rs757568169	72	L>F		No	ClinGen ExAC gnomAD
rs1272825497 CA385811942	73	K>E		No	ClinGen gnomAD
CA6693252 rs754046671	74	E>V		No	ClinGen ExAC gnomAD
rs1282670313 CA385811754	79	V>A		No	ClinGen gnomAD
CA6693250 rs150984893	81	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs760659380 CA6693249	82	A>S		No	ClinGen ExAC gnomAD
CA6693248 rs371580619	83	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	84	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1464053060 CA385811630	84	N>S		No	ClinGen gnomAD
CA6693246 rs760053121	85	E>G		No	ClinGen ExAC
CA239314206 rs928486257	86	H>R		No	ClinGen TOPMed
rs901920174 CA239312852	87	H>R		No	ClinGen TOPMed
rs761486193 CA6693217	87	H>Y		No	ClinGen ExAC
rs1288447103 CA385810748	89	N>D		No	ClinGen gnomAD
CA385810732 rs1316452407	90	A>T		No	ClinGen gnomAD
rs776026711 CA6693209	90	A>V		No	ClinGen ExAC gnomAD
CA6693208 rs768145943	91	T>A		No	ClinGen ExAC gnomAD
rs1302392218 CA385810674	93	D>E		No	ClinGen gnomAD
rs780127865 CA6693206	95	I>S		No	ClinGen ExAC gnomAD
rs141363529 CA6693204	96	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1452569798 CA385810625	97	G>S		No	ClinGen gnomAD
rs778731569 CA6693203	99	M>T		No	ClinGen ExAC gnomAD
rs559522979 CA239312805	105	K>*		No	ClinGen gnomAD
rs752910893 CA6693201	106	K>T		No	ClinGen ExAC TOPMed gnomAD
rs752116384 CA6693198	111	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs752116384 CA6693199	111	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA239312743 rs914536259	112	I>S		No	ClinGen Ensembl
rs914536259 CA385810346	112	I>T		No	ClinGen Ensembl
CA6693196 rs763346738	112	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6693195 rs114239473	113	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385810282 rs1468644744	115	R>K		No	ClinGen TOPMed
rs761376479 CA6693193	124	A>S		No	ClinGen ExAC gnomAD
TCGA novel	126	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385810025 rs1283686002	129	F>L		No	ClinGen TOPMed gnomAD
rs775611984 CA6693189	131	Q>H		No	ClinGen ExAC gnomAD
CA6693141 rs774337591	132	A>G		No	ClinGen ExAC
CA6693142 rs759400330	132	A>S		No	ClinGen ExAC
rs749084587 CA6693139	133	V>I		No	ClinGen ExAC gnomAD
rs11540407 VAR_049680 CA6693138	134	R>Q		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA385809820 rs1242673336	136	L>F		No	ClinGen TOPMed gnomAD
rs1319278521 CA385809768	138	D>G		No	ClinGen TOPMed
CA239312380 rs554807424	138	D>N		No	ClinGen 1000Genomes gnomAD
CA385809741 rs1248348155	139	D>G		No	ClinGen gnomAD
rs1248348155 CA385809738	139	D>V		No	ClinGen gnomAD
TCGA novel	140	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385809722 rs1195110433	140	V>I		No	ClinGen gnomAD
CA239312374 rs778224926	141	A>P		No	ClinGen TOPMed gnomAD
CA385809711 rs778224926	141	A>T		No	ClinGen TOPMed gnomAD
rs1016978782 CA239312372	142	C>R		No	ClinGen Ensembl
CA6693136 rs768895750	143	D>H		No	ClinGen ExAC gnomAD
rs768895750 CA385809673	143	D>N		No	ClinGen ExAC gnomAD
rs747184760 CA6693135	146	K>I		No	ClinGen ExAC gnomAD
rs780120414 CA6693133	148	G>D		No	ClinGen ExAC TOPMed gnomAD
CA6693131 rs746421178	149	S>C		No	ClinGen ExAC gnomAD
CA6693132 rs746421178	149	S>F		No	ClinGen ExAC gnomAD
rs774242188 CA239312326	152	R>G		No	ClinGen Ensembl
CA385809476 rs1391289689	153	N>D		No	ClinGen gnomAD
CA385809468 rs1391967461	153	N>I		No	ClinGen gnomAD
rs757605341 CA385809462	153	N>K		No	ClinGen ExAC TOPMed gnomAD
CA6693128 rs754262328	154	K>R		No	ClinGen ExAC
CA239312315 rs115453918	159	K>R		No	ClinGen 1000Genomes
rs1006843823 CA385809321	160	R>*		No	ClinGen TOPMed gnomAD
rs1006843823 CA239312305	160	R>G		No	ClinGen TOPMed gnomAD
CA385809320 rs1441652902	160	R>Q		No	ClinGen TOPMed gnomAD
rs954096801 CA239312300	161	R>G		No	ClinGen gnomAD
CA385809308 rs1398418992	161	R>K		No	ClinGen TOPMed
rs1271622488 CA385809285	162	Q>R		No	ClinGen TOPMed gnomAD
CA385809268 rs1181050757	163	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6693126 rs114719907	163	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs755848514 CA6693125	167	P>R		No	ClinGen ExAC gnomAD
CA385809197 rs1334373011	168	K>E		No	ClinGen TOPMed
rs200862058 CA6693124	168	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs370067745 COSM1513133 CA6693123	169	G>V	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1490108584 CA385809162	170	S>Y		No	ClinGen gnomAD
rs758128238 CA239312262	171	T>A		No	ClinGen Ensembl
rs759069916 CA385809126	172	L>*		No	ClinGen ExAC gnomAD
rs1352986918 CA385809137	172	L>M		No	ClinGen TOPMed
CA6693122 rs759069916	172	L>S		No	ClinGen ExAC gnomAD
CA6693106 rs780966094	174	A>T		No	ClinGen ExAC gnomAD
CA6693103 rs765756898	176	E>D		No	ClinGen ExAC gnomAD
rs765074465 CA6693099	180	N>D		No	ClinGen ExAC gnomAD
rs761575297 CA6693098	181	C>Y		No	ClinGen ExAC gnomAD
CA239312163 rs200385352	183	I>V		No	ClinGen TOPMed gnomAD
CA6693096 rs772372057	186	Q>E		No	ClinGen ExAC gnomAD
CA6693095 rs148121880	186	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1208433509 CA6693093	190	V>I		No	ClinGen Ensembl
CA239312132 rs369851209	191	S>P		No	ClinGen ESP TOPMed
CA6693092 rs774506696	193	I>V		No	ClinGen ExAC
rs770852853 CA6693091	196	F>S		No	ClinGen ExAC gnomAD
TCGA novel	197	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6693090 rs749880529	197	S>R		No	ClinGen ExAC gnomAD
TCGA novel	198	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866858892 CA239312107	198	G>V		No	ClinGen Ensembl
rs1468083261 CA385808624	200	K>E		No	ClinGen TOPMed
CA6693071 rs376056617	205	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1415938217 CA385808021	210	M>I		No	ClinGen TOPMed
CA6693068 rs777069443	210	M>T		No	ClinGen ExAC gnomAD
CA6693069 rs748619176	210	M>V		No	ClinGen ExAC gnomAD
CA6693067 rs768837362	212	N>H		No	ClinGen ExAC gnomAD
rs771353668 CA239311371	212	N>S		No	ClinGen TOPMed
CA239311394 rs771353668	212	N>T		No	ClinGen TOPMed
rs1452024737 CA385807973	213	I>T		No	ClinGen TOPMed gnomAD
rs746743291 CA6693066	215	P>A		No	ClinGen ExAC gnomAD
rs1299851554 CA385807937	215	P>Q		No	ClinGen gnomAD
CA6693064 rs544886803	217	Y>F		No	ClinGen 1000Genomes ExAC gnomAD
CA6693031 rs748618258	221	S>*		No	ClinGen ExAC
rs201035934 CA6693029	223	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1316361236 CA385807608	226	R>T		No	ClinGen gnomAD
rs1225230836 CA385807585	227	E>D		No	ClinGen TOPMed gnomAD
CA6693028 rs376593401	227	E>V		No	ClinGen ESP ExAC gnomAD
CA385807542 rs1282383203	230	K>I		No	ClinGen gnomAD
rs372563816 CA239310431	231	D>E		No	ClinGen ESP TOPMed
rs1363642515 CA385807532	231	D>N		No	ClinGen gnomAD
TCGA novel	231	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA239310422 rs901056089	235	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA6693024 rs188885620	235	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6693023 rs188885620	235	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs17853239 CA239310405	247	K>R		No	ClinGen Ensembl
CA6693020 rs765481167	248	H>R		No	ClinGen ExAC gnomAD
rs761971509 CA6693019	252	N>I		No	ClinGen ExAC gnomAD
rs777235058 CA6693018	253	K>E		No	ClinGen ExAC TOPMed gnomAD
COSM75183 rs368830982 CA6693017	254	R>C	ovary Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs761193901 CA6693016 COSM1364229	254	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA6693015 rs775728423	255	K>R		No	ClinGen ExAC TOPMed gnomAD
rs772354362 CA6693014	257	P>A		No	ClinGen ExAC gnomAD
rs1262355242 CA385807138	257	P>L		No	ClinGen gnomAD
TCGA novel	258	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773976000 CA6693012	260	K>N		No	ClinGen ExAC gnomAD
TCGA novel	261	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1050532182 CA239310374	265	E>G		No	ClinGen TOPMed
CA385807012 rs1338119127	265	E>K		No	ClinGen TOPMed gnomAD
rs748720677 CA6693008	266	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs551077175 CA6693007	267	T>M		No	ClinGen 1000Genomes ExAC gnomAD
CA6693002 rs750732688	273	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1438977017 CA385806863	273	Q>K		No	ClinGen TOPMed
CA239310292 rs940122183	274	P>R		No	ClinGen Ensembl
rs17853240 CA239310287	275	E>K		No	ClinGen Ensembl
CA385806798 rs1185504419	276	S>I		No	ClinGen gnomAD
CA6692983 rs768623012	278	I>L		No	ClinGen ExAC TOPMed gnomAD
rs746830762 CA6692982	278	I>M		No	ClinGen ExAC gnomAD
rs779945359 CA6692981	279	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs373922981 CA6692977	284	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6692978 rs373922981	284	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1450653214 CA385806493	288	F>L		No	ClinGen gnomAD
rs753248715 CA6692976	289	L>W		No	ClinGen ExAC gnomAD
CA6692973 rs139059786	293	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1566103851 CA385806377	294	K>E		No	ClinGen Ensembl
CA6692972 rs751946450	294	K>R		No	ClinGen ExAC TOPMed gnomAD
CA385806352 rs1481761266	295	K>R		No	ClinGen TOPMed
rs370477950 CA6692970	296	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs577073370 CA6692971	296	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6692968 rs764714445	298	K>Q		No	ClinGen ExAC gnomAD
rs1003764963 CA239308877	299	M>R		No	ClinGen TOPMed gnomAD
CA385806279 rs1003764963	299	M>T		No	ClinGen TOPMed gnomAD
CA385806259 rs1414311297	300	E>G		No	ClinGen TOPMed
rs375580761 CA6692966	301	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1362010247 CA385806231	302	I>M		No	ClinGen gnomAD
CA385806233 rs1566103813	302	I>T		No	ClinGen Ensembl
CA6692965 rs535120586	302	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA385806224 rs372522544	303	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA6692942 rs1594066725	304	A>A		No	ClinGen Ensembl
CA6692943 rs373507415	304	A>D		No	ClinGen ESP TOPMed
CA6692941 rs570700905	307	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA239305443 rs570700905	307	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA6692939 rs773973140	310	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6692938 rs770080673	311	S>G		No	ClinGen ExAC gnomAD
CA6692937 rs781256310	311	S>I		No	ClinGen ExAC TOPMed gnomAD
CA6692936 rs781256310	311	S>N		No	ClinGen ExAC TOPMed gnomAD
CA6692935 rs369198555	312	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs747573872 CA6692934	312	K>T		No	ClinGen ExAC gnomAD
CA385805841 rs1389090924	316	E>D		No	ClinGen gnomAD
TCGA novel	316	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758729953 CA6692932	317	R>I		No	ClinGen ExAC gnomAD
rs1462223482 CA385805782	320	A>T		No	ClinGen gnomAD
CA385805774 rs1245540882	320	A>V		No	ClinGen gnomAD
CA385805720 rs1202291662	323	P>L		No	ClinGen gnomAD
rs750831850 CA6692931	324	P>S		No	ClinGen ExAC gnomAD
rs1194518608 CA385805643	328	P>R		No	ClinGen TOPMed
CA239305360 rs376955252	329	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs376955252 CA6692929	329	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs765462145 CA6692930	329	I>V		No	ClinGen ExAC TOPMed gnomAD
CA6692928 rs753534788	330	V>A		No	ClinGen ExAC gnomAD
CA6692927 rs763753001	334	E>K		No	ClinGen ExAC gnomAD
rs376672311 CA239303309	335	A>V		No	ClinGen ESP
CA6692899 rs779398848	336	S>F		No	ClinGen ExAC gnomAD
rs1400723533 CA385805508	337	T>A		No	ClinGen gnomAD
rs1212848424 CA385805502	338	E>A		No	ClinGen TOPMed
rs757680953 CA6692898	338	E>Q		No	ClinGen ExAC gnomAD
CA239303290 rs17853238	339	T>A		No	ClinGen TOPMed
rs17853238 CA385805496	339	T>S		No	ClinGen TOPMed
CA385805491 rs1405717582	340	K>E		No	ClinGen gnomAD
TCGA novel	340	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6692897 rs753590345	341	I>F		No	ClinGen ExAC gnomAD
rs1200492532 CA385805479	341	I>M		No	ClinGen gnomAD
CA385805482 rs1251518165	341	I>T		No	ClinGen gnomAD
rs1263838033 CA385805468	343	V>L		No	ClinGen gnomAD
CA385805459 rs1220946410	344	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	345	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1452712341 CA385805453	345	S>I		No	ClinGen TOPMed
CA385805450 rs1286300268	346	I>V		No	ClinGen gnomAD
rs755783070 CA6692895	348	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	352	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374297882 CA6692893	352	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs751449948 CA6692891 COSM943497	354	K>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs933038188 CA239303145	355	N>S		No	ClinGen TOPMed
rs566245480 CA239303144	356	K>T		No	ClinGen Ensembl
rs1594065032 CA919122038	357	K>E		No	ClinGen Ensembl
rs1346422173 CA385805361	358	L>P		No	ClinGen TOPMed gnomAD
rs1345880739 CA385805364	358	L>V		No	ClinGen TOPMed gnomAD
CA385805353 rs766222607	360	A>P		No	ClinGen ExAC TOPMed gnomAD
CA6692888 rs766222607	360	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	360	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6692887 rs762715577	361	L>F		No	ClinGen ExAC TOPMed gnomAD
CA385805342 rs1411776262	362	T>A		No	ClinGen gnomAD
CA6692886 rs760760484	362	T>I		No	ClinGen ExAC
rs760760484 CA6692883	362	T>K		No	ClinGen ExAC
rs760760484 CA6692884	362	T>R		No	ClinGen ExAC
rs1400358932 CA385805331	364	E>A		No	ClinGen TOPMed
rs1177607491 CA385805334	364	E>K		No	ClinGen gnomAD
CA239303106 rs372067400	365	E>G		No	ClinGen ESP gnomAD
CA385805310 rs1265565227	367	A>S		No	ClinGen gnomAD
rs775643670 CA6692882	368	L>F		No	ClinGen ExAC gnomAD
rs772040272 CA6692881	368	L>R		No	ClinGen ExAC
rs1201385452 CA385805298	369	K>R		No	ClinGen gnomAD
rs1328454253 CA385805277	372	A>T		No	ClinGen TOPMed
rs746442927 CA6692879	375	K>E		No	ClinGen ExAC gnomAD
TCGA novel	375	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs933617147 CA239303035	377	K>E		No	ClinGen Ensembl
rs530056027 CA6692876	377	K>N		No	ClinGen 1000Genomes TOPMed
rs1262076078 CA385805223	379	K>R		No	ClinGen TOPMed gnomAD
rs140273898 CA6692870	381	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs761148574	381	K>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1260836798 CA385805199	382	K>S		No	ClinGen gnomAD

No associated diseases with Q13601

1 regional properties for Q13601

Type	Name	Position	InterPro Accession
domain	Ribosome receptor lysine/proline rich	29 - 166	IPR007794

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intercellular bridge	A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
small-subunit processome	A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

1 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name	Definition
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3B7L9	KRR1	KRR1 small subunit processome component homolog	Bos taurus (Bovine)	PR

10	20	30	40	50	60
MASPSLERPE	KGAGKSEFRN	QKPKPENQDE	SELLTVPDGW	KEPAFSKEDN	PRGLLEESSF
70	80	90	100	110	120
ATLFPKYREA	YLKECWPLVQ	KALNEHHVNA	TLDLIEGSMT	VCTTKKTFDP	YIIIRARDLI
130	140	150	160	170	180
KLLARSVSFE	QAVRILQDDV	ACDIIKIGSL	VRNKERFVKR	RQRLIGPKGS	TLKALELLTN
190	200	210	220	230	240
CYIMVQGNTV	SAIGPFSGLK	EVRKVVLDTM	KNIHPIYNIK	SLMIKRELAK	DSELRSQSWE
250	260	270	280	290	300
RFLPQFKHKN	VNKRKEPKKK	TVKKEYTPFP	PPQPESQIDK	ELASGEYFLK	ANQKKRQKME
310	320	330	340	350	360
AIKAKQAEAI	SKRQEERNKA	FIPPKEKPIV	KPKEASTETK	IDVASIKEKV	KKAKNKKLGA
370	380
LTAEEIALKM	EADEKKKKKK	K